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Advanced prostate cancer risk in relation to toenail selenium levels.

Abstract

BACKGROUND

Selenium may prevent advanced prostate cancer (PCa), but most studies on this topic were conducted in populations with moderate to high selenium status. We investigated the association of toenail selenium, reflecting long-term selenium exposure, and advanced PCa risk in a population from the Netherlands where low selenium status is widespread.

METHODS

The analysis was conducted in the prospective Netherlands Cohort Study, which included 58 279 men aged 55 to 69 years at baseline in 1986. All cohort members completed a baseline questionnaire, and approximately 79% of participants provided toenail clippings, which were used for toenail selenium measurements using instrumental neutron activation analysis. Incident advanced PCa case subjects from the entire cohort were identified during 17.3 years of follow-up. The study employed a case-cohort design for which a random subcohort was sampled at baseline. Hazard ratios and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. All tests were two-sided.

RESULTS

Complete toenail selenium data were available for 898 advanced (International Union Against Cancer stage III/IV) PCa case subjects and 1176 subcohort members. The average toenail selenium concentration of subcohort members was 0.550 µg/g. Toenail selenium was associated with a reduced risk of advanced PCa; adjusted hazard ratio for the highest vs lowest quintile was 0.37 (95% CI = 0.27 to 0.51; P trend < .001). For stage IV PCa, men in the highest vs lowest quintile of toenail selenium had an adjusted hazard ratio of 0.30 (95% CI = 0.21 to 0.45; P trend < .001).

CONCLUSIONS

Toenail selenium was associated with a substantial decrease in risk of advanced PCa.

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    Affiliations of authors: Department of Epidemiology, GROW School for Oncology and Developmental Biology, (MSG, BAJV, PAvdB) and Department of Toxicology, NUTRIM School for Nutrition, Toxicology, and Metabolism (FJvS), Maastricht University, Maastricht, the Netherlands; TNO, Leiden, the Netherlands (RAG).

    , , ,

    Source

    Journal of the National Cancer Institute 105:18 2013 Sep 18 pg 1394-401

    MeSH

    Aged
    Antioxidants
    Humans
    Incidence
    Male
    Middle Aged
    Nails
    Neoplasm Staging
    Netherlands
    Odds Ratio
    Proportional Hazards Models
    Prospective Studies
    Prostatic Neoplasms
    Risk Assessment
    Risk Factors
    Selenium
    Surveys and Questionnaires
    Trace Elements

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23878355

    Citation

    Geybels, Milan S., et al. "Advanced Prostate Cancer Risk in Relation to Toenail Selenium Levels." Journal of the National Cancer Institute, vol. 105, no. 18, 2013, pp. 1394-401.
    Geybels MS, Verhage BA, van Schooten FJ, et al. Advanced prostate cancer risk in relation to toenail selenium levels. J Natl Cancer Inst. 2013;105(18):1394-401.
    Geybels, M. S., Verhage, B. A., van Schooten, F. J., Goldbohm, R. A., & van den Brandt, P. A. (2013). Advanced prostate cancer risk in relation to toenail selenium levels. Journal of the National Cancer Institute, 105(18), pp. 1394-401. doi:10.1093/jnci/djt186.
    Geybels MS, et al. Advanced Prostate Cancer Risk in Relation to Toenail Selenium Levels. J Natl Cancer Inst. 2013 Sep 18;105(18):1394-401. PubMed PMID: 23878355.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Advanced prostate cancer risk in relation to toenail selenium levels. AU - Geybels,Milan S, AU - Verhage,Bas A J, AU - van Schooten,Frederik J, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, Y1 - 2013/07/22/ PY - 2013/7/24/entrez PY - 2013/7/24/pubmed PY - 2013/11/5/medline SP - 1394 EP - 401 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 105 IS - 18 N2 - BACKGROUND: Selenium may prevent advanced prostate cancer (PCa), but most studies on this topic were conducted in populations with moderate to high selenium status. We investigated the association of toenail selenium, reflecting long-term selenium exposure, and advanced PCa risk in a population from the Netherlands where low selenium status is widespread. METHODS: The analysis was conducted in the prospective Netherlands Cohort Study, which included 58 279 men aged 55 to 69 years at baseline in 1986. All cohort members completed a baseline questionnaire, and approximately 79% of participants provided toenail clippings, which were used for toenail selenium measurements using instrumental neutron activation analysis. Incident advanced PCa case subjects from the entire cohort were identified during 17.3 years of follow-up. The study employed a case-cohort design for which a random subcohort was sampled at baseline. Hazard ratios and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. All tests were two-sided. RESULTS: Complete toenail selenium data were available for 898 advanced (International Union Against Cancer stage III/IV) PCa case subjects and 1176 subcohort members. The average toenail selenium concentration of subcohort members was 0.550 µg/g. Toenail selenium was associated with a reduced risk of advanced PCa; adjusted hazard ratio for the highest vs lowest quintile was 0.37 (95% CI = 0.27 to 0.51; P trend < .001). For stage IV PCa, men in the highest vs lowest quintile of toenail selenium had an adjusted hazard ratio of 0.30 (95% CI = 0.21 to 0.45; P trend < .001). CONCLUSIONS: Toenail selenium was associated with a substantial decrease in risk of advanced PCa. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/23878355/Advanced_prostate_cancer_risk_in_relation_to_toenail_selenium_levels_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djt186 DB - PRIME DP - Unbound Medicine ER -