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Advanced prostate cancer risk in relation to toenail selenium levels.
J Natl Cancer Inst 2013; 105(18):1394-401JNCI

Abstract

BACKGROUND

Selenium may prevent advanced prostate cancer (PCa), but most studies on this topic were conducted in populations with moderate to high selenium status. We investigated the association of toenail selenium, reflecting long-term selenium exposure, and advanced PCa risk in a population from the Netherlands where low selenium status is widespread.

METHODS

The analysis was conducted in the prospective Netherlands Cohort Study, which included 58 279 men aged 55 to 69 years at baseline in 1986. All cohort members completed a baseline questionnaire, and approximately 79% of participants provided toenail clippings, which were used for toenail selenium measurements using instrumental neutron activation analysis. Incident advanced PCa case subjects from the entire cohort were identified during 17.3 years of follow-up. The study employed a case-cohort design for which a random subcohort was sampled at baseline. Hazard ratios and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. All tests were two-sided.

RESULTS

Complete toenail selenium data were available for 898 advanced (International Union Against Cancer stage III/IV) PCa case subjects and 1176 subcohort members. The average toenail selenium concentration of subcohort members was 0.550 µg/g. Toenail selenium was associated with a reduced risk of advanced PCa; adjusted hazard ratio for the highest vs lowest quintile was 0.37 (95% CI = 0.27 to 0.51; P trend < .001). For stage IV PCa, men in the highest vs lowest quintile of toenail selenium had an adjusted hazard ratio of 0.30 (95% CI = 0.21 to 0.45; P trend < .001).

CONCLUSIONS

Toenail selenium was associated with a substantial decrease in risk of advanced PCa.

Authors+Show Affiliations

Affiliations of authors: Department of Epidemiology, GROW School for Oncology and Developmental Biology, (MSG, BAJV, PAvdB) and Department of Toxicology, NUTRIM School for Nutrition, Toxicology, and Metabolism (FJvS), Maastricht University, Maastricht, the Netherlands; TNO, Leiden, the Netherlands (RAG).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23878355

Citation

Geybels, Milan S., et al. "Advanced Prostate Cancer Risk in Relation to Toenail Selenium Levels." Journal of the National Cancer Institute, vol. 105, no. 18, 2013, pp. 1394-401.
Geybels MS, Verhage BA, van Schooten FJ, et al. Advanced prostate cancer risk in relation to toenail selenium levels. J Natl Cancer Inst. 2013;105(18):1394-401.
Geybels, M. S., Verhage, B. A., van Schooten, F. J., Goldbohm, R. A., & van den Brandt, P. A. (2013). Advanced prostate cancer risk in relation to toenail selenium levels. Journal of the National Cancer Institute, 105(18), pp. 1394-401. doi:10.1093/jnci/djt186.
Geybels MS, et al. Advanced Prostate Cancer Risk in Relation to Toenail Selenium Levels. J Natl Cancer Inst. 2013 Sep 18;105(18):1394-401. PubMed PMID: 23878355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advanced prostate cancer risk in relation to toenail selenium levels. AU - Geybels,Milan S, AU - Verhage,Bas A J, AU - van Schooten,Frederik J, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, Y1 - 2013/07/22/ PY - 2013/7/24/entrez PY - 2013/7/24/pubmed PY - 2013/11/5/medline SP - 1394 EP - 401 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 105 IS - 18 N2 - BACKGROUND: Selenium may prevent advanced prostate cancer (PCa), but most studies on this topic were conducted in populations with moderate to high selenium status. We investigated the association of toenail selenium, reflecting long-term selenium exposure, and advanced PCa risk in a population from the Netherlands where low selenium status is widespread. METHODS: The analysis was conducted in the prospective Netherlands Cohort Study, which included 58 279 men aged 55 to 69 years at baseline in 1986. All cohort members completed a baseline questionnaire, and approximately 79% of participants provided toenail clippings, which were used for toenail selenium measurements using instrumental neutron activation analysis. Incident advanced PCa case subjects from the entire cohort were identified during 17.3 years of follow-up. The study employed a case-cohort design for which a random subcohort was sampled at baseline. Hazard ratios and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. All tests were two-sided. RESULTS: Complete toenail selenium data were available for 898 advanced (International Union Against Cancer stage III/IV) PCa case subjects and 1176 subcohort members. The average toenail selenium concentration of subcohort members was 0.550 µg/g. Toenail selenium was associated with a reduced risk of advanced PCa; adjusted hazard ratio for the highest vs lowest quintile was 0.37 (95% CI = 0.27 to 0.51; P trend < .001). For stage IV PCa, men in the highest vs lowest quintile of toenail selenium had an adjusted hazard ratio of 0.30 (95% CI = 0.21 to 0.45; P trend < .001). CONCLUSIONS: Toenail selenium was associated with a substantial decrease in risk of advanced PCa. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/23878355/Advanced_prostate_cancer_risk_in_relation_to_toenail_selenium_levels_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djt186 DB - PRIME DP - Unbound Medicine ER -