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Relationship between oral D-amphetamine self-administration and ratings of subjective effects: do subjective-effects ratings correspond with a progressive-ratio measure of drug-taking behavior?
Behav Pharmacol. 2013 Sep; 24(5-6):533-42.BP

Abstract

The abuse potential of drugs has traditionally been determined in humans using subjective ratings of drug effects. However, drug self-administration procedures also provide valuable information about the reinforcing effects of drugs that may contribute to their potential for abuse. Although ratings of subjective effects and drug self-administration data are generally concordant, some divergent findings have been reported. Therefore, the aim of the present analysis was to directly investigate the relationship between the subjective-effects profile and self-administration of oral D-amphetamine in healthy volunteers with a history of stimulant use or abuse, using Pearson's correlational analyses. The results indicated that positive subjective and reinforcing effects significantly increased as a function of D-amphetamine dose. Further, significant, but modest, correlations were observed between ratings of six of 17 total items (Any Effect, High, Like Drug, Good Effects, Willing to Pay For, and Willing to Take Again) and D-amphetamine self-administration under a progressive-ratio schedule of reinforcement. The current findings suggest that, at least under the current set of conditions with oral D-amphetamine, subjective-effects measures and drug self-administration data likely provide different but complimentary information about abuse potential. The most informative findings will thus be obtained from studies that use ratings of subjective effects and drug self-administration methods.

Authors+Show Affiliations

Departments of aBehavioral Science, University of Kentucky College of Arts and Sciences, Lexington, KY 40536-0086, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23881044

Citation

Bolin, B Levi, et al. "Relationship Between Oral D-amphetamine Self-administration and Ratings of Subjective Effects: Do Subjective-effects Ratings Correspond With a Progressive-ratio Measure of Drug-taking Behavior?" Behavioural Pharmacology, vol. 24, no. 5-6, 2013, pp. 533-42.
Bolin BL, Reynolds AR, Stoops WW, et al. Relationship between oral D-amphetamine self-administration and ratings of subjective effects: do subjective-effects ratings correspond with a progressive-ratio measure of drug-taking behavior? Behav Pharmacol. 2013;24(5-6):533-42.
Bolin, B. L., Reynolds, A. R., Stoops, W. W., & Rush, C. R. (2013). Relationship between oral D-amphetamine self-administration and ratings of subjective effects: do subjective-effects ratings correspond with a progressive-ratio measure of drug-taking behavior? Behavioural Pharmacology, 24(5-6), 533-42. https://doi.org/10.1097/FBP.0b013e3283645047
Bolin BL, et al. Relationship Between Oral D-amphetamine Self-administration and Ratings of Subjective Effects: Do Subjective-effects Ratings Correspond With a Progressive-ratio Measure of Drug-taking Behavior. Behav Pharmacol. 2013;24(5-6):533-42. PubMed PMID: 23881044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between oral D-amphetamine self-administration and ratings of subjective effects: do subjective-effects ratings correspond with a progressive-ratio measure of drug-taking behavior? AU - Bolin,B Levi, AU - Reynolds,Anna R, AU - Stoops,William W, AU - Rush,Craig R, PY - 2013/7/25/entrez PY - 2013/7/25/pubmed PY - 2013/10/30/medline SP - 533 EP - 42 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 24 IS - 5-6 N2 - The abuse potential of drugs has traditionally been determined in humans using subjective ratings of drug effects. However, drug self-administration procedures also provide valuable information about the reinforcing effects of drugs that may contribute to their potential for abuse. Although ratings of subjective effects and drug self-administration data are generally concordant, some divergent findings have been reported. Therefore, the aim of the present analysis was to directly investigate the relationship between the subjective-effects profile and self-administration of oral D-amphetamine in healthy volunteers with a history of stimulant use or abuse, using Pearson's correlational analyses. The results indicated that positive subjective and reinforcing effects significantly increased as a function of D-amphetamine dose. Further, significant, but modest, correlations were observed between ratings of six of 17 total items (Any Effect, High, Like Drug, Good Effects, Willing to Pay For, and Willing to Take Again) and D-amphetamine self-administration under a progressive-ratio schedule of reinforcement. The current findings suggest that, at least under the current set of conditions with oral D-amphetamine, subjective-effects measures and drug self-administration data likely provide different but complimentary information about abuse potential. The most informative findings will thus be obtained from studies that use ratings of subjective effects and drug self-administration methods. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/23881044/Relationship_between_oral_D_amphetamine_self_administration_and_ratings_of_subjective_effects:_do_subjective_effects_ratings_correspond_with_a_progressive_ratio_measure_of_drug_taking_behavior L2 - https://doi.org/10.1097/FBP.0b013e3283645047 DB - PRIME DP - Unbound Medicine ER -