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Lack of association of homocysteine concentrations with oxidative stress, alterations in carotid intima media thickness and endothelial reactivity in prepubertal children.
Ann Nutr Metab. 2013; 63(1-2):25-31.AN

Abstract

BACKGROUND AND AIMS

Our purpose was to assess the presence of risk factors for cardiovascular diseases (alterations in the lipid profile, fasting glycaemia, high arterial pressure values, oxidative stress, increased intima media thickness and impaired endothelium-dependent vasodilation) in prepubertal children with elevated homocysteine (Hcy) levels.

METHODS

In a cross-sectional study, 35 children with Hcy levels ≥7.3 μmol/l were matched by gender and age with 29 children with Hcy levels ≤4.1 μmol/l. Our collected data included weight, height, waist circumference, systemic arterial pressure, lipid profile, fasting glycaemia and oxidative stress markers. A Doppler ultrasound was performed to measure the carotid intima media thickness and the endothelium-dependent vasodilation of the brachial artery.

RESULTS

There were no statistically significant differences between the groups regarding the lipid profile and fasting glycaemia, blood pressure or oxidative stress. Overweight and obesity (body mass index z-score > +1) were more frequent in the group with Hcy ≥7.3 μmol/l when compared to the group with Hcy ≤4.1 μmol/l [13/35 (37.1%) vs. 4/29 (13.8%); p = 0.035]. After adjusting for nutritional status, there were no differences in the intima media thickness and endothelium-dependent vasodilation between children with high and low Hcy levels.

CONCLUSIONS

Among the cardiovascular risk factors investigated in the present study, which was based on prepubertal children, only overweight and obesity were associated with increased Hcy concentrations (≥7.3 μmol/l).

Authors+Show Affiliations

Pediatric Department, Department of Morphology and Physiology, Faculdade de Medicina do ABC, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23881171

Citation

Suano de Souza, Fabíola Isabel, et al. "Lack of Association of Homocysteine Concentrations With Oxidative Stress, Alterations in Carotid Intima Media Thickness and Endothelial Reactivity in Prepubertal Children." Annals of Nutrition & Metabolism, vol. 63, no. 1-2, 2013, pp. 25-31.
Suano de Souza FI, D'Almeida V, Fonseca FL, et al. Lack of association of homocysteine concentrations with oxidative stress, alterations in carotid intima media thickness and endothelial reactivity in prepubertal children. Ann Nutr Metab. 2013;63(1-2):25-31.
Suano de Souza, F. I., D'Almeida, V., Fonseca, F. L., Hix, S., Miranda, R., Gomes de Torres Rossi, R., Ribeiro, R., & Saccardo Sarni, R. O. (2013). Lack of association of homocysteine concentrations with oxidative stress, alterations in carotid intima media thickness and endothelial reactivity in prepubertal children. Annals of Nutrition & Metabolism, 63(1-2), 25-31. https://doi.org/10.1159/000350314
Suano de Souza FI, et al. Lack of Association of Homocysteine Concentrations With Oxidative Stress, Alterations in Carotid Intima Media Thickness and Endothelial Reactivity in Prepubertal Children. Ann Nutr Metab. 2013;63(1-2):25-31. PubMed PMID: 23881171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association of homocysteine concentrations with oxidative stress, alterations in carotid intima media thickness and endothelial reactivity in prepubertal children. AU - Suano de Souza,Fabíola Isabel, AU - D'Almeida,Vânia, AU - Fonseca,Fernando Luiz Affonso, AU - Hix,Sonia, AU - Miranda,Robson, AU - Gomes de Torres Rossi,Rosana, AU - Ribeiro,Renata, AU - Saccardo Sarni,Roseli Oselka, Y1 - 2013/07/20/ PY - 2012/07/15/received PY - 2013/02/28/accepted PY - 2013/7/25/entrez PY - 2013/7/25/pubmed PY - 2014/4/17/medline SP - 25 EP - 31 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 63 IS - 1-2 N2 - BACKGROUND AND AIMS: Our purpose was to assess the presence of risk factors for cardiovascular diseases (alterations in the lipid profile, fasting glycaemia, high arterial pressure values, oxidative stress, increased intima media thickness and impaired endothelium-dependent vasodilation) in prepubertal children with elevated homocysteine (Hcy) levels. METHODS: In a cross-sectional study, 35 children with Hcy levels ≥7.3 μmol/l were matched by gender and age with 29 children with Hcy levels ≤4.1 μmol/l. Our collected data included weight, height, waist circumference, systemic arterial pressure, lipid profile, fasting glycaemia and oxidative stress markers. A Doppler ultrasound was performed to measure the carotid intima media thickness and the endothelium-dependent vasodilation of the brachial artery. RESULTS: There were no statistically significant differences between the groups regarding the lipid profile and fasting glycaemia, blood pressure or oxidative stress. Overweight and obesity (body mass index z-score > +1) were more frequent in the group with Hcy ≥7.3 μmol/l when compared to the group with Hcy ≤4.1 μmol/l [13/35 (37.1%) vs. 4/29 (13.8%); p = 0.035]. After adjusting for nutritional status, there were no differences in the intima media thickness and endothelium-dependent vasodilation between children with high and low Hcy levels. CONCLUSIONS: Among the cardiovascular risk factors investigated in the present study, which was based on prepubertal children, only overweight and obesity were associated with increased Hcy concentrations (≥7.3 μmol/l). SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/23881171/Lack_of_association_of_homocysteine_concentrations_with_oxidative_stress_alterations_in_carotid_intima_media_thickness_and_endothelial_reactivity_in_prepubertal_children_ L2 - https://www.karger.com?DOI=10.1159/000350314 DB - PRIME DP - Unbound Medicine ER -