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Female SHR have greater blood pressure sensitivity and renal T cell infiltration following chronic NOS inhibition than males.
Am J Physiol Regul Integr Comp Physiol. 2013 Oct 01; 305(7):R701-10.AJ

Abstract

Nitric oxide is a critical regulator of blood pressure (BP) and inflammation, and female spontaneously hypertensive rats (SHR) have higher renal nitric oxide bioavailability than males. We hypothesize that female SHR will have a greater rise in BP and renal T cell infiltration in response to nitric oxide synthase (NOS) inhibition than males. Both male and female SHR displayed a dose-dependent increase in BP to the nonspecific NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME: 2, 5, and 7 mg·kg(-1)·day(-1) for 4 days each); however, females exhibited a greater increase in BP than males. Treatment of male and female SHR with 7 mg·kg(-1)·day(-1) L-NAME for 2 wk significantly increased BP in both sexes; however, prior exposure to L-NAME only increased BP sensitivity to chronic NOS inhibition in females. L-NAME-induced hypertension increased renal T cell infiltration and indices of renal injury in both sexes, yet female SHR exhibited greater increases in Th17 cells and greater decreases in regulatory T cells than males. Chronic L-NAME was also associated with larger increases in renal cortical adhesion molecule expression in female SHR. The use of triple therapy to block L-NAME-mediated increases in BP attenuated L-NAME-induced increases in renal T cell counts and normalized adhesion molecule expression in SHR, suggesting that L-NAME-induced increases in renal T cells were dependent on both increases in BP and NOS inhibition. Our data suggest that NOS is critical in the ability of SHR, females in particular, to maintain BP and limit a pro-inflammatory renal T cell profile.

Authors+Show Affiliations

Departments of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23883679

Citation

Brinson, Krystal N., et al. "Female SHR Have Greater Blood Pressure Sensitivity and Renal T Cell Infiltration Following Chronic NOS Inhibition Than Males." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 305, no. 7, 2013, pp. R701-10.
Brinson KN, Elmarakby AA, Tipton AJ, et al. Female SHR have greater blood pressure sensitivity and renal T cell infiltration following chronic NOS inhibition than males. Am J Physiol Regul Integr Comp Physiol. 2013;305(7):R701-10.
Brinson, K. N., Elmarakby, A. A., Tipton, A. J., Crislip, G. R., Yamamoto, T., Baban, B., & Sullivan, J. C. (2013). Female SHR have greater blood pressure sensitivity and renal T cell infiltration following chronic NOS inhibition than males. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 305(7), R701-10. https://doi.org/10.1152/ajpregu.00226.2013
Brinson KN, et al. Female SHR Have Greater Blood Pressure Sensitivity and Renal T Cell Infiltration Following Chronic NOS Inhibition Than Males. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R701-10. PubMed PMID: 23883679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Female SHR have greater blood pressure sensitivity and renal T cell infiltration following chronic NOS inhibition than males. AU - Brinson,Krystal N, AU - Elmarakby,Ahmed A, AU - Tipton,Ashlee J, AU - Crislip,G Ryan, AU - Yamamoto,Tatsuo, AU - Baban,Babak, AU - Sullivan,Jennifer C, Y1 - 2013/07/24/ PY - 2013/7/26/entrez PY - 2013/7/26/pubmed PY - 2013/12/16/medline KW - hypertension KW - inflammation KW - kidney injury KW - nitric oxide synthase KW - sex SP - R701 EP - 10 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am J Physiol Regul Integr Comp Physiol VL - 305 IS - 7 N2 - Nitric oxide is a critical regulator of blood pressure (BP) and inflammation, and female spontaneously hypertensive rats (SHR) have higher renal nitric oxide bioavailability than males. We hypothesize that female SHR will have a greater rise in BP and renal T cell infiltration in response to nitric oxide synthase (NOS) inhibition than males. Both male and female SHR displayed a dose-dependent increase in BP to the nonspecific NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME: 2, 5, and 7 mg·kg(-1)·day(-1) for 4 days each); however, females exhibited a greater increase in BP than males. Treatment of male and female SHR with 7 mg·kg(-1)·day(-1) L-NAME for 2 wk significantly increased BP in both sexes; however, prior exposure to L-NAME only increased BP sensitivity to chronic NOS inhibition in females. L-NAME-induced hypertension increased renal T cell infiltration and indices of renal injury in both sexes, yet female SHR exhibited greater increases in Th17 cells and greater decreases in regulatory T cells than males. Chronic L-NAME was also associated with larger increases in renal cortical adhesion molecule expression in female SHR. The use of triple therapy to block L-NAME-mediated increases in BP attenuated L-NAME-induced increases in renal T cell counts and normalized adhesion molecule expression in SHR, suggesting that L-NAME-induced increases in renal T cells were dependent on both increases in BP and NOS inhibition. Our data suggest that NOS is critical in the ability of SHR, females in particular, to maintain BP and limit a pro-inflammatory renal T cell profile. SN - 1522-1490 UR - https://www.unboundmedicine.com/medline/citation/23883679/Female_SHR_have_greater_blood_pressure_sensitivity_and_renal_T_cell_infiltration_following_chronic_NOS_inhibition_than_males_ L2 - https://journals.physiology.org/doi/10.1152/ajpregu.00226.2013?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -