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The emerging novel Middle East respiratory syndrome coronavirus: the "knowns" and "unknowns".
J Formos Med Assoc. 2013 Jul; 112(7):372-81.JF

Abstract

A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5, which we discovered in 2007 from bats in Hong Kong, has recently emerged in the Middle East to cause a severe acute respiratory syndrome (SARS)-like infection in humans. The first laboratory-confirmed case, which involved a 60-year-old man from Bisha, the Kingdom of Saudi Arabia (KSA), who died of rapidly progressive community-acquired pneumonia and acute renal failure, was announced by the World Health Organization (WHO) on September 23, 2012. Since then, a total of 70 cases, including 39 fatalities, have been reported in the Middle East and Europe. Recent clusters involving epidemiologically-linked household contacts and hospital contacts in the Middle East, Europe, and Africa strongly suggested possible human-to-human transmission. Clinical and laboratory research data generated in the past few months have provided new insights into the possible animal reservoirs, transmissibility, and virulence of MERS-CoV, and the optimal laboratory diagnostic options and potential antiviral targets for MERS-CoV-associated infection.

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Authors+Show Affiliations

Chan JF
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China. pcywoo@hkucc.hku.hk
Lau SK
No affiliation info available
Woo PC
No affiliation info available

MeSH

AnimalsChiropteraCoronaviridaeCoronaviridae InfectionsDisease ReservoirsDrug DiscoveryHumansMiddle EastSevere Acute Respiratory Syndrome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23883791

Clinical Trial Links

Expanded Access to Zofin for Patients With COVID-19

Citation

Chan, Jasper Fuk-Woo, et al. "The Emerging Novel Middle East Respiratory Syndrome Coronavirus: the "knowns" and "unknowns"." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 112, no. 7, 2013, pp. 372-81.
Chan JF, Lau SK, Woo PC. The emerging novel Middle East respiratory syndrome coronavirus: the "knowns" and "unknowns". J Formos Med Assoc. 2013;112(7):372-81.
Chan, J. F., Lau, S. K., & Woo, P. C. (2013). The emerging novel Middle East respiratory syndrome coronavirus: the "knowns" and "unknowns". Journal of the Formosan Medical Association = Taiwan Yi Zhi, 112(7), 372-81. https://doi.org/10.1016/j.jfma.2013.05.010
Chan JF, Lau SK, Woo PC. The Emerging Novel Middle East Respiratory Syndrome Coronavirus: the "knowns" and "unknowns". J Formos Med Assoc. 2013;112(7):372-81. PubMed PMID: 23883791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The emerging novel Middle East respiratory syndrome coronavirus: the "knowns" and "unknowns". AU - Chan,Jasper Fuk-Woo, AU - Lau,Susanna Kar-Pui, AU - Woo,Patrick Chiu-Yat, Y1 - 2013/07/21/ PY - 2013/04/16/received PY - 2013/05/13/revised PY - 2013/05/14/accepted PY - 2013/7/26/entrez PY - 2013/7/26/pubmed PY - 2014/4/26/medline KW - EMC KW - Middle East KW - SARS KW - coronavirus KW - human SP - 372 EP - 81 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 112 IS - 7 N2 - A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5, which we discovered in 2007 from bats in Hong Kong, has recently emerged in the Middle East to cause a severe acute respiratory syndrome (SARS)-like infection in humans. The first laboratory-confirmed case, which involved a 60-year-old man from Bisha, the Kingdom of Saudi Arabia (KSA), who died of rapidly progressive community-acquired pneumonia and acute renal failure, was announced by the World Health Organization (WHO) on September 23, 2012. Since then, a total of 70 cases, including 39 fatalities, have been reported in the Middle East and Europe. Recent clusters involving epidemiologically-linked household contacts and hospital contacts in the Middle East, Europe, and Africa strongly suggested possible human-to-human transmission. Clinical and laboratory research data generated in the past few months have provided new insights into the possible animal reservoirs, transmissibility, and virulence of MERS-CoV, and the optimal laboratory diagnostic options and potential antiviral targets for MERS-CoV-associated infection. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/23883791/The_emerging_novel_Middle_East_respiratory_syndrome_coronavirus:_the_"knowns"_and_"unknowns"_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(13)00177-0 DB - PRIME DP - Unbound Medicine ER -