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Dopaminergic responsiveness to apomorphine after chronic treatment with subcutaneous lisuride infusion in Parkinson's disease.
Mov Disord. 1990; 5(3):260-2.MD

Abstract

The aim of this study was to assess whether or not continuous infusion of lisuride in combination with intermittent levodopa-carbidopa administration was associated with tolerance. Intravenous apomorphine was given to four patients before initiation of chronic treatment with subcutaneous lisuride infusion and oral levodopa. The study was repeated under identical conditions after a mean of 18 months of treatment. In no case was the motor response induced by apomorphine infusion reduced as compared to baseline assessment. Choreic dyskinesias accompanying the "on" state were enhanced in all patients. These findings suggest that chronic continuous infusion of a dopamine agonist like lisuride, associated with oral levodopa, is not accompanied by tolerance or down-regulation of striatal dopaminergic receptors.

Authors+Show Affiliations

Department of Neurology, University of Navarra, Pamplona, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2388647

Citation

Vaamonde, J, et al. "Dopaminergic Responsiveness to Apomorphine After Chronic Treatment With Subcutaneous Lisuride Infusion in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 5, no. 3, 1990, pp. 260-2.
Vaamonde J, Luquin MR, Obeso JA. Dopaminergic responsiveness to apomorphine after chronic treatment with subcutaneous lisuride infusion in Parkinson's disease. Mov Disord. 1990;5(3):260-2.
Vaamonde, J., Luquin, M. R., & Obeso, J. A. (1990). Dopaminergic responsiveness to apomorphine after chronic treatment with subcutaneous lisuride infusion in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 5(3), 260-2.
Vaamonde J, Luquin MR, Obeso JA. Dopaminergic Responsiveness to Apomorphine After Chronic Treatment With Subcutaneous Lisuride Infusion in Parkinson's Disease. Mov Disord. 1990;5(3):260-2. PubMed PMID: 2388647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopaminergic responsiveness to apomorphine after chronic treatment with subcutaneous lisuride infusion in Parkinson's disease. AU - Vaamonde,J, AU - Luquin,M R, AU - Obeso,J A, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 260 EP - 2 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 5 IS - 3 N2 - The aim of this study was to assess whether or not continuous infusion of lisuride in combination with intermittent levodopa-carbidopa administration was associated with tolerance. Intravenous apomorphine was given to four patients before initiation of chronic treatment with subcutaneous lisuride infusion and oral levodopa. The study was repeated under identical conditions after a mean of 18 months of treatment. In no case was the motor response induced by apomorphine infusion reduced as compared to baseline assessment. Choreic dyskinesias accompanying the "on" state were enhanced in all patients. These findings suggest that chronic continuous infusion of a dopamine agonist like lisuride, associated with oral levodopa, is not accompanied by tolerance or down-regulation of striatal dopaminergic receptors. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/2388647/Dopaminergic_responsiveness_to_apomorphine_after_chronic_treatment_with_subcutaneous_lisuride_infusion_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.870050316 DB - PRIME DP - Unbound Medicine ER -