Tags

Type your tag names separated by a space and hit enter

Patient characteristics and severity of human rhinovirus infections in children.
J Clin Virol. 2013 Sep; 58(1):216-20.JC

Abstract

BACKGROUND

It is increasingly recognized that human rhinoviruses (HRV) can be associated with severe infections. However, conflicting results have been reported on the relative prevalence and severity of the three HRV species.

OBJECTIVES

The relative prevalence and clinical characteristics of HRV-A, B and C, in children attending a South London teaching hospital were investigated retrospectively.

STUDY DESIGN

Children aged<16 years with episodes of respiratory tract infections and detectable entero/rhinovirus RNA in respiratory samples between November 2009 and December 2010 were investigated. Retrospective case review was performed and patients' characteristics recorded.

RESULTS

Entero/rhinoviruses were the commonest viral pathogens (498/2316; 21.5%). Amongst 204 infection episodes associated with entero/rhinovirus, 167 were typed HRV, HRV-C was the most prevalent (99/167, 59.3%) followed by HRV-A (60/167; 35.9%) and HRV-B (8/167, 4.8%). The severity spectrum of HRV-A and HRV-C infections were similar and affected all parts of the respiratory tract. Co-pathogens were observed in 54 (26.5%) episodes. Severity was increased in patients with non-viral co-pathogens and those with an underlying respiratory condition. Univariate and multiple regression analyses of potential prognostic variables including age, co-pathogens and underlying respiratory illnesses showed that mono-infection with HRV-C, as compared with other HRV species, was associated with more severe disease in young children<3 years.

CONCLUSIONS

HRV-C was the most prevalent species and on its own was associated with severe disease in children<3 years. The association between infection with HRV species and clinical presentation is complex and affected by many confounding factors.

Authors+Show Affiliations

Department of Infectious Diseases, King's College London School of Medicine, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23886500

Citation

Lauinger, Ina L., et al. "Patient Characteristics and Severity of Human Rhinovirus Infections in Children." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 58, no. 1, 2013, pp. 216-20.
Lauinger IL, Bible JM, Halligan EP, et al. Patient characteristics and severity of human rhinovirus infections in children. J Clin Virol. 2013;58(1):216-20.
Lauinger, I. L., Bible, J. M., Halligan, E. P., Bangalore, H., Tosas, O., Aarons, E. J., MacMahon, E., & Tong, C. Y. (2013). Patient characteristics and severity of human rhinovirus infections in children. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 58(1), 216-20. https://doi.org/10.1016/j.jcv.2013.06.042
Lauinger IL, et al. Patient Characteristics and Severity of Human Rhinovirus Infections in Children. J Clin Virol. 2013;58(1):216-20. PubMed PMID: 23886500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patient characteristics and severity of human rhinovirus infections in children. AU - Lauinger,Ina L, AU - Bible,Jon M, AU - Halligan,Eugene P, AU - Bangalore,Harish, AU - Tosas,Olga, AU - Aarons,Emma J, AU - MacMahon,Eithne, AU - Tong,Cheuk Y W, Y1 - 2013/07/22/ PY - 2013/04/25/received PY - 2013/06/23/revised PY - 2013/06/30/accepted PY - 2013/7/27/entrez PY - 2013/7/28/pubmed PY - 2014/3/4/medline KW - 5′NCR KW - 5′noncoding region KW - Co-pathogens KW - HDU KW - HMPV KW - HRV KW - High Dependency Unit KW - Human rhinoviruses KW - ICU KW - IQR KW - Intensive Care Unit KW - LRTI KW - PIV KW - RSV KW - RTI KW - Severity KW - URTI KW - Young children KW - human metapneumovirus KW - human rhinovirus KW - interquartile range KW - lower respiratory tract infection KW - parainfluenzaviruses KW - respiratory syncytial viruses KW - respiratory tract infection KW - upper respiratory tract infection SP - 216 EP - 20 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 58 IS - 1 N2 - BACKGROUND: It is increasingly recognized that human rhinoviruses (HRV) can be associated with severe infections. However, conflicting results have been reported on the relative prevalence and severity of the three HRV species. OBJECTIVES: The relative prevalence and clinical characteristics of HRV-A, B and C, in children attending a South London teaching hospital were investigated retrospectively. STUDY DESIGN: Children aged<16 years with episodes of respiratory tract infections and detectable entero/rhinovirus RNA in respiratory samples between November 2009 and December 2010 were investigated. Retrospective case review was performed and patients' characteristics recorded. RESULTS: Entero/rhinoviruses were the commonest viral pathogens (498/2316; 21.5%). Amongst 204 infection episodes associated with entero/rhinovirus, 167 were typed HRV, HRV-C was the most prevalent (99/167, 59.3%) followed by HRV-A (60/167; 35.9%) and HRV-B (8/167, 4.8%). The severity spectrum of HRV-A and HRV-C infections were similar and affected all parts of the respiratory tract. Co-pathogens were observed in 54 (26.5%) episodes. Severity was increased in patients with non-viral co-pathogens and those with an underlying respiratory condition. Univariate and multiple regression analyses of potential prognostic variables including age, co-pathogens and underlying respiratory illnesses showed that mono-infection with HRV-C, as compared with other HRV species, was associated with more severe disease in young children<3 years. CONCLUSIONS: HRV-C was the most prevalent species and on its own was associated with severe disease in children<3 years. The association between infection with HRV species and clinical presentation is complex and affected by many confounding factors. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/23886500/Patient_characteristics_and_severity_of_human_rhinovirus_infections_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(13)00274-6 DB - PRIME DP - Unbound Medicine ER -