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Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial.
Pain 2013; 154(11):2441-51PAIN

Abstract

Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive and pronociceptive properties. We conducted a randomized, single-blinded, parallel-group clinical trial to assess clinical and biochemical effects of targeted alteration in dietary n-3 and n-6 fatty acids for treatment of chronic headaches. After a 4-week preintervention phase, ambulatory patients with chronic daily headache undergoing usual care were randomized to 1 of 2 intensive, food-based 12-week dietary interventions: a high n-3 plus low n-6 (H3-L6) intervention, or a low n-6 (L6) intervention. Clinical outcomes included the Headache Impact Test (HIT-6, primary clinical outcome), Headache Days per month, and Headache Hours per day. Biochemical outcomes included the erythrocyte n-6 in highly unsaturated fatty acids (HUFA) score (primary biochemical outcome) and bioactive n-3 and n-6 derivatives. Fifty-six of 67 patients completed the intervention. Both groups achieved targeted intakes of n-3 and n-6 fatty acids. In intention-to-treat analysis, the H3-L6 intervention produced significantly greater improvement in the HIT-6 score (-7.5 vs -2.1; P<0.001) and the number of Headache Days per month (-8.8 vs -4.0; P=0.02), compared to the L6 group. The H3-L6 intervention also produced significantly greater reductions in Headache Hours per day (-4.6 vs -1.2; P=0.01) and the n-6 in HUFA score (-21.0 vs -4.0%; P<0.001), and greater increases in antinociceptive n-3 pathway markers 18-hydroxy-eicosapentaenoic acid (+118.4 vs +61.1%; P<0.001) and 17-hydroxy-docosahexaenoic acid (+170.2 vs +27.2; P<0.001). A dietary intervention increasing n-3 and reducing n-6 fatty acids reduced headache pain, altered antinociceptive lipid mediators, and improved quality-of-life in this population.

Authors+Show Affiliations

Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA; Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina-Chapel Hill, NC, USA. Electronic address: chris.ramsden@nih.gov.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23886520

Citation

Ramsden, Christopher E., et al. "Targeted Alteration of Dietary N-3 and N-6 Fatty Acids for the Treatment of Chronic Headaches: a Randomized Trial." Pain, vol. 154, no. 11, 2013, pp. 2441-51.
Ramsden CE, Faurot KR, Zamora D, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154(11):2441-51.
Ramsden, C. E., Faurot, K. R., Zamora, D., Suchindran, C. M., Macintosh, B. A., Gaylord, S., ... Mann, J. D. (2013). Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain, 154(11), pp. 2441-51. doi:10.1016/j.pain.2013.07.028.
Ramsden CE, et al. Targeted Alteration of Dietary N-3 and N-6 Fatty Acids for the Treatment of Chronic Headaches: a Randomized Trial. Pain. 2013;154(11):2441-51. PubMed PMID: 23886520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. AU - Ramsden,Christopher E, AU - Faurot,Keturah R, AU - Zamora,Daisy, AU - Suchindran,Chirayath M, AU - Macintosh,Beth A, AU - Gaylord,Susan, AU - Ringel,Amit, AU - Hibbeln,Joseph R, AU - Feldstein,Ariel E, AU - Mori,Trevor A, AU - Barden,Anne, AU - Lynch,Chanee, AU - Coble,Rebecca, AU - Mas,Emilie, AU - Palsson,Olafur, AU - Barrow,David A, AU - Mann,J Douglas, Y1 - 2013/07/22/ PY - 2013/06/06/received PY - 2013/07/11/revised PY - 2013/07/17/accepted PY - 2013/7/27/entrez PY - 2013/7/28/pubmed PY - 2014/5/29/medline KW - Clinical trial KW - Headache KW - Migraine KW - Omega-3 KW - Omega-6 SP - 2441 EP - 51 JF - Pain JO - Pain VL - 154 IS - 11 N2 - Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive and pronociceptive properties. We conducted a randomized, single-blinded, parallel-group clinical trial to assess clinical and biochemical effects of targeted alteration in dietary n-3 and n-6 fatty acids for treatment of chronic headaches. After a 4-week preintervention phase, ambulatory patients with chronic daily headache undergoing usual care were randomized to 1 of 2 intensive, food-based 12-week dietary interventions: a high n-3 plus low n-6 (H3-L6) intervention, or a low n-6 (L6) intervention. Clinical outcomes included the Headache Impact Test (HIT-6, primary clinical outcome), Headache Days per month, and Headache Hours per day. Biochemical outcomes included the erythrocyte n-6 in highly unsaturated fatty acids (HUFA) score (primary biochemical outcome) and bioactive n-3 and n-6 derivatives. Fifty-six of 67 patients completed the intervention. Both groups achieved targeted intakes of n-3 and n-6 fatty acids. In intention-to-treat analysis, the H3-L6 intervention produced significantly greater improvement in the HIT-6 score (-7.5 vs -2.1; P<0.001) and the number of Headache Days per month (-8.8 vs -4.0; P=0.02), compared to the L6 group. The H3-L6 intervention also produced significantly greater reductions in Headache Hours per day (-4.6 vs -1.2; P=0.01) and the n-6 in HUFA score (-21.0 vs -4.0%; P<0.001), and greater increases in antinociceptive n-3 pathway markers 18-hydroxy-eicosapentaenoic acid (+118.4 vs +61.1%; P<0.001) and 17-hydroxy-docosahexaenoic acid (+170.2 vs +27.2; P<0.001). A dietary intervention increasing n-3 and reducing n-6 fatty acids reduced headache pain, altered antinociceptive lipid mediators, and improved quality-of-life in this population. SN - 1872-6623 UR - https://www.unboundmedicine.com/medline/citation/23886520/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3959(13)00396-5 DB - PRIME DP - Unbound Medicine ER -