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An application of Pavlovian principles to the problems of obesity and cognitive decline.

Abstract

An enormous amount of research has been aimed at identifying biological and environmental factors that are contributing to the current global obesity pandemic. The present paper reviews recent findings which suggest that obesity is attributable, at least in part, to a disruption of the Pavlovian control of energy regulation. Within our framework, this disruption occurs when (a) consumption of sweet-tasting, but low calorie or noncaloric, foods and beverages reduces the ability of sweet tastes to predict the postingestive caloric consequences of intake and (b) consuming diets high in saturated fat and sugar (a.k.a., Western diet) impairs hippocampal-dependent learning and memory processes that are involved with the use of interoceptive "satiety" signals to anticipate when food and eating are not followed by appetitive postingestive outcomes. The paper concludes with discussion of a "vicious-cycle" model which links obesity to cognitive decline.

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  • Authors+Show Affiliations

    ,

    American University, Washington, DC, United States. Electronic address: terryd@american.edu.

    ,

    American University, Washington, DC, United States.

    Purdue University, West Lafayette, IN, United States.

    Source

    Neurobiology of learning and memory 108: 2014 Feb pg 172-84

    MeSH

    Animals
    Cognition Disorders
    Conditioning, Classical
    Energy Intake
    Energy Metabolism
    Hippocampus
    Humans
    Hyperphagia
    Learning
    Mice
    Obesity
    Rats

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    23887140

    Citation

    Davidson, T L., et al. "An Application of Pavlovian Principles to the Problems of Obesity and Cognitive Decline." Neurobiology of Learning and Memory, vol. 108, 2014, pp. 172-84.
    Davidson TL, Sample CH, Swithers SE. An application of Pavlovian principles to the problems of obesity and cognitive decline. Neurobiol Learn Mem. 2014;108:172-84.
    Davidson, T. L., Sample, C. H., & Swithers, S. E. (2014). An application of Pavlovian principles to the problems of obesity and cognitive decline. Neurobiology of Learning and Memory, 108, pp. 172-84. doi:10.1016/j.nlm.2013.07.014.
    Davidson TL, Sample CH, Swithers SE. An Application of Pavlovian Principles to the Problems of Obesity and Cognitive Decline. Neurobiol Learn Mem. 2014;108:172-84. PubMed PMID: 23887140.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An application of Pavlovian principles to the problems of obesity and cognitive decline. AU - Davidson,T L, AU - Sample,C H, AU - Swithers,S E, Y1 - 2013/07/22/ PY - 2013/03/01/received PY - 2013/07/12/revised PY - 2013/07/15/accepted PY - 2013/7/27/entrez PY - 2013/7/28/pubmed PY - 2014/10/15/medline KW - Dementia KW - Energy regulation KW - Hippocampus KW - Ingestive behavior KW - Learning KW - Western diet SP - 172 EP - 84 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 108 N2 - An enormous amount of research has been aimed at identifying biological and environmental factors that are contributing to the current global obesity pandemic. The present paper reviews recent findings which suggest that obesity is attributable, at least in part, to a disruption of the Pavlovian control of energy regulation. Within our framework, this disruption occurs when (a) consumption of sweet-tasting, but low calorie or noncaloric, foods and beverages reduces the ability of sweet tastes to predict the postingestive caloric consequences of intake and (b) consuming diets high in saturated fat and sugar (a.k.a., Western diet) impairs hippocampal-dependent learning and memory processes that are involved with the use of interoceptive "satiety" signals to anticipate when food and eating are not followed by appetitive postingestive outcomes. The paper concludes with discussion of a "vicious-cycle" model which links obesity to cognitive decline. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/23887140/An_application_of_Pavlovian_principles_to_the_problems_of_obesity_and_cognitive_decline_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(13)00127-5 DB - PRIME DP - Unbound Medicine ER -