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Increased risk for overweight among Swedish children born to mothers with gestational diabetes mellitus.
Pediatr Diabetes. 2014 Feb; 15(1):57-66.PD

Abstract

OBJECTIVE

Investigate the effects of maternal gestational diabetes mellitus (GDM) on height, weight, and body mass index (BMI) in offspring compared both to their siblings and to age-specific BMI reference values in Sweden. Their parents present BMI was also investigated.

METHODS

The growth of 232 offspring to 110 women with at least one pregnancy with GDM, were studied up to 12 yr of age. Height and weight of children were collected from Health Care Centres and compared to age-specific reference values in Sweden. Self-reported height and weight of the parents were collected at follow-up.

RESULTS

For boys, weight was higher at birth and at 8-10 yr of age, giving a higher BMI at 7-10 yr of age. Girls had an accelerated height growth at all ages, combined with an increased weight of varying degree resulting in higher BMI at birth and at 4-12 yr of age. A similar pattern was observed in siblings born after a normal pregnancy. Median BMI of mothers at follow-up was 25.4 (18.3-59.5 n = 105) and 26.5 (18.6-38.1 n = 90) for fathers.

CONCLUSIONS

Children born to mothers with prior GDM have a higher risk of overweight and obesity later in life. This is most likely due to life style habits rather than intrauterine factors, as the same BMI pattern was found in siblings born after a normal pregnancy. However, the design of the study could not rule out the role of genetic factors. Priority should be given to early life style intervention in these families.

Authors+Show Affiliations

Department of Paediatrics, Institution of Clinical Science, Lund University, Helsingborg Hospital, 251 87, Helsingborg, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23890345

Citation

Nilsson, Charlotta, et al. "Increased Risk for Overweight Among Swedish Children Born to Mothers With Gestational Diabetes Mellitus." Pediatric Diabetes, vol. 15, no. 1, 2014, pp. 57-66.
Nilsson C, Carlsson A, Landin-Olsson M. Increased risk for overweight among Swedish children born to mothers with gestational diabetes mellitus. Pediatr Diabetes. 2014;15(1):57-66.
Nilsson, C., Carlsson, A., & Landin-Olsson, M. (2014). Increased risk for overweight among Swedish children born to mothers with gestational diabetes mellitus. Pediatric Diabetes, 15(1), 57-66. https://doi.org/10.1111/pedi.12059
Nilsson C, Carlsson A, Landin-Olsson M. Increased Risk for Overweight Among Swedish Children Born to Mothers With Gestational Diabetes Mellitus. Pediatr Diabetes. 2014;15(1):57-66. PubMed PMID: 23890345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk for overweight among Swedish children born to mothers with gestational diabetes mellitus. AU - Nilsson,Charlotta, AU - Carlsson,Annelie, AU - Landin-Olsson,Mona, Y1 - 2013/07/24/ PY - 2013/01/29/received PY - 2012/12/06/revised PY - 2013/05/22/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2014/9/26/medline KW - gestational diabetes mellitus KW - offspring KW - overweight SP - 57 EP - 66 JF - Pediatric diabetes JO - Pediatr Diabetes VL - 15 IS - 1 N2 - OBJECTIVE: Investigate the effects of maternal gestational diabetes mellitus (GDM) on height, weight, and body mass index (BMI) in offspring compared both to their siblings and to age-specific BMI reference values in Sweden. Their parents present BMI was also investigated. METHODS: The growth of 232 offspring to 110 women with at least one pregnancy with GDM, were studied up to 12 yr of age. Height and weight of children were collected from Health Care Centres and compared to age-specific reference values in Sweden. Self-reported height and weight of the parents were collected at follow-up. RESULTS: For boys, weight was higher at birth and at 8-10 yr of age, giving a higher BMI at 7-10 yr of age. Girls had an accelerated height growth at all ages, combined with an increased weight of varying degree resulting in higher BMI at birth and at 4-12 yr of age. A similar pattern was observed in siblings born after a normal pregnancy. Median BMI of mothers at follow-up was 25.4 (18.3-59.5 n = 105) and 26.5 (18.6-38.1 n = 90) for fathers. CONCLUSIONS: Children born to mothers with prior GDM have a higher risk of overweight and obesity later in life. This is most likely due to life style habits rather than intrauterine factors, as the same BMI pattern was found in siblings born after a normal pregnancy. However, the design of the study could not rule out the role of genetic factors. Priority should be given to early life style intervention in these families. SN - 1399-5448 UR - https://www.unboundmedicine.com/medline/citation/23890345/Increased_risk_for_overweight_among_Swedish_children_born_to_mothers_with_gestational_diabetes_mellitus_ L2 - https://doi.org/10.1111/pedi.12059 DB - PRIME DP - Unbound Medicine ER -