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Current clinical status on the preventive effects of cranberry consumption against urinary tract infections.
Nutr Res. 2013 Aug; 33(8):595-607.NR

Abstract

Urinary tract infections (UTIs) represent a common and quite costly medical problem, primarily affecting the female population which may be due to a shorter urethra. The bacterium Escherichia coli are mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have widely been studied in vitro, and laboratory and clinical studies have also been performed to elucidate the mechanisms of cranberry actions and the clinical benefits of cranberry consumption against UTIs. The present review aimed to summarize the proposed mechanisms of cranberry actions against UTIs and the clinical trials that evaluated the efficacy of supplementing cranberry products in different subpopulations. Taking into consideration the existing data, cranberry consumption may prevent bacterial adherence to uroepithelial cells which reduces the development of UTI. Cranberry consumption could also decreasing UTI related symptoms by suppressing inflammatory cascades as an immunologic response to bacteria invasion. The existing clinical trials suggest that the beneficial effects of cranberry against UTIs seem to be prophylactic by preventing the development of infections; however, they exert low effectiveness in populations at increased risk for contracting UTIs. Additional well-designed, double-blind, placebo-controlled clinical trials that use standardized cranberry products are strongly justified in order to determine the efficiency of cranberry on the prevention of UTIs in susceptible populations.

Authors+Show Affiliations

Department of Food Science and Nutrition, University of the Aegean, Myrina, Lemnos, Greece.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23890348

Citation

Vasileiou, Ioanna, et al. "Current Clinical Status On the Preventive Effects of Cranberry Consumption Against Urinary Tract Infections." Nutrition Research (New York, N.Y.), vol. 33, no. 8, 2013, pp. 595-607.
Vasileiou I, Katsargyris A, Theocharis S, et al. Current clinical status on the preventive effects of cranberry consumption against urinary tract infections. Nutr Res. 2013;33(8):595-607.
Vasileiou, I., Katsargyris, A., Theocharis, S., & Giaginis, C. (2013). Current clinical status on the preventive effects of cranberry consumption against urinary tract infections. Nutrition Research (New York, N.Y.), 33(8), 595-607. https://doi.org/10.1016/j.nutres.2013.05.018
Vasileiou I, et al. Current Clinical Status On the Preventive Effects of Cranberry Consumption Against Urinary Tract Infections. Nutr Res. 2013;33(8):595-607. PubMed PMID: 23890348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current clinical status on the preventive effects of cranberry consumption against urinary tract infections. AU - Vasileiou,Ioanna, AU - Katsargyris,Athanasios, AU - Theocharis,Stamatios, AU - Giaginis,Constantinos, Y1 - 2013/07/01/ PY - 2012/07/08/received PY - 2013/05/26/revised PY - 2013/05/30/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2014/2/8/medline KW - Antimicrobial activity KW - COX-2 KW - Clinical trials KW - Cranberry KW - E coli KW - Escherichia coli KW - HBA KW - HCA KW - Immune response KW - Inflammatory reaction KW - LPS KW - NO KW - PACs KW - SMX KW - TMP KW - TNF-α KW - UA KW - UTI KW - Urinary tract infections KW - cyclooxygenase-2 KW - hydroxybenzoic acid KW - hydroxycinnamic KW - lipopolysaccharide KW - nitric oxide KW - proanthocyanidin polymers KW - sulfamethoxazole KW - trimethoprim KW - tumor necrosis factor-α KW - urinary tract infection KW - ursolic acid SP - 595 EP - 607 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 33 IS - 8 N2 - Urinary tract infections (UTIs) represent a common and quite costly medical problem, primarily affecting the female population which may be due to a shorter urethra. The bacterium Escherichia coli are mainly responsible for most uncomplicated UTIs. Cranberry antibacterial effects have widely been studied in vitro, and laboratory and clinical studies have also been performed to elucidate the mechanisms of cranberry actions and the clinical benefits of cranberry consumption against UTIs. The present review aimed to summarize the proposed mechanisms of cranberry actions against UTIs and the clinical trials that evaluated the efficacy of supplementing cranberry products in different subpopulations. Taking into consideration the existing data, cranberry consumption may prevent bacterial adherence to uroepithelial cells which reduces the development of UTI. Cranberry consumption could also decreasing UTI related symptoms by suppressing inflammatory cascades as an immunologic response to bacteria invasion. The existing clinical trials suggest that the beneficial effects of cranberry against UTIs seem to be prophylactic by preventing the development of infections; however, they exert low effectiveness in populations at increased risk for contracting UTIs. Additional well-designed, double-blind, placebo-controlled clinical trials that use standardized cranberry products are strongly justified in order to determine the efficiency of cranberry on the prevention of UTIs in susceptible populations. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/23890348/Current_clinical_status_on_the_preventive_effects_of_cranberry_consumption_against_urinary_tract_infections_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00128-0 DB - PRIME DP - Unbound Medicine ER -