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Dietary vitamin D intake is not associated with 25-hydroxyvitamin D3 or parathyroid hormone in elderly subjects, whereas the calcium-to-phosphate ratio affects parathyroid hormone.
Nutr Res. 2013 Aug; 33(8):661-7.NR

Abstract

This cross-sectional study investigates whether serum 25-hydroxyvitamin D3 [25(OH)D3] and intact parathyroid hormone (iPTH) are affected by vitamin D, calcium, or phosphate intake in 140 independently living elderly subjects from Germany (99 women and 41 men; age, 66-96 years). We hypothesized that habitual dietary intakes of vitamin D, calcium, and phosphate are not associated with 25(OH)D3 or iPTH and that body mass index confounds these associations. Serum 25(OH)D3 and iPTH were measured by an electrochemiluminescence immunoassay. Dietary intake was determined using a 3-day estimated dietary record. The median dietary intake levels of vitamin D, calcium, and phosphate were 3 μg/d, 999 mg/d, and 1250 mg/d, respectively. Multiple regression analyses confirmed that dietary vitamin D and calcium did not affect 25(OH)D3 or iPTH; however, supplemental intakes of vitamin D and calcium were associated with 25(OH)D3 after adjustment for age, sex, body composition, sun exposure, physical activity, and smoking. In addition, phosphate intake and the calcium-to-phosphate ratio were associated with iPTH after multiple adjustments. In a subgroup analysis, calcium and vitamin D supplements, as well as phosphate intake, were associated with 25(OH)D3 and/or iPTH in normal-weight subjects only. Our results indicate that habitual dietary vitamin D and calcium intakes have no independent effects on 25(OH)D3 or iPTH in elderly subjects without vitamin D deficiency, whereas phosphate intake and the calcium-to-phosphate ratio affect iPTH. However, vitamin D and calcium supplements may increase 25(OH)D3 and decrease iPTH, even during the summer, but the impact of supplements may depend on body mass index.

Authors+Show Affiliations

Institute of Nutritional Science, Justus-Liebig-University, Giessen, Germany.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23890356

Citation

Jungert, Alexandra, and Monika Neuhäuser-Berthold. "Dietary Vitamin D Intake Is Not Associated With 25-hydroxyvitamin D3 or Parathyroid Hormone in Elderly Subjects, Whereas the Calcium-to-phosphate Ratio Affects Parathyroid Hormone." Nutrition Research (New York, N.Y.), vol. 33, no. 8, 2013, pp. 661-7.
Jungert A, Neuhäuser-Berthold M. Dietary vitamin D intake is not associated with 25-hydroxyvitamin D3 or parathyroid hormone in elderly subjects, whereas the calcium-to-phosphate ratio affects parathyroid hormone. Nutr Res. 2013;33(8):661-7.
Jungert, A., & Neuhäuser-Berthold, M. (2013). Dietary vitamin D intake is not associated with 25-hydroxyvitamin D3 or parathyroid hormone in elderly subjects, whereas the calcium-to-phosphate ratio affects parathyroid hormone. Nutrition Research (New York, N.Y.), 33(8), 661-7. https://doi.org/10.1016/j.nutres.2013.05.011
Jungert A, Neuhäuser-Berthold M. Dietary Vitamin D Intake Is Not Associated With 25-hydroxyvitamin D3 or Parathyroid Hormone in Elderly Subjects, Whereas the Calcium-to-phosphate Ratio Affects Parathyroid Hormone. Nutr Res. 2013;33(8):661-7. PubMed PMID: 23890356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary vitamin D intake is not associated with 25-hydroxyvitamin D3 or parathyroid hormone in elderly subjects, whereas the calcium-to-phosphate ratio affects parathyroid hormone. AU - Jungert,Alexandra, AU - Neuhäuser-Berthold,Monika, Y1 - 2013/06/28/ PY - 2012/10/30/received PY - 2013/05/11/revised PY - 2013/05/23/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2014/2/8/medline KW - 25(OH)D KW - 25(OH)D(3) KW - 25-Hydroxyvitamin D(3) KW - 25-hydroxyvitamin D KW - 25-hydroxyvitamin D(3) KW - BMI KW - Ca/P ratio KW - Calcium intake KW - Elderly German subjects KW - GISELA KW - PAL KW - Parathyroid hormone KW - Phosphate intake KW - Spearman correlation coefficient KW - TBF KW - Vitamin D intake KW - body mass index KW - calcium-to-phosphate ratio KW - iPTH KW - intact parathyroid hormone KW - log KW - logarithmically transformed KW - longitudinal study on nutrition and health status in senior citizens of Giessen KW - physical activity level KW - r(S) KW - total body fat SP - 661 EP - 7 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 33 IS - 8 N2 - This cross-sectional study investigates whether serum 25-hydroxyvitamin D3 [25(OH)D3] and intact parathyroid hormone (iPTH) are affected by vitamin D, calcium, or phosphate intake in 140 independently living elderly subjects from Germany (99 women and 41 men; age, 66-96 years). We hypothesized that habitual dietary intakes of vitamin D, calcium, and phosphate are not associated with 25(OH)D3 or iPTH and that body mass index confounds these associations. Serum 25(OH)D3 and iPTH were measured by an electrochemiluminescence immunoassay. Dietary intake was determined using a 3-day estimated dietary record. The median dietary intake levels of vitamin D, calcium, and phosphate were 3 μg/d, 999 mg/d, and 1250 mg/d, respectively. Multiple regression analyses confirmed that dietary vitamin D and calcium did not affect 25(OH)D3 or iPTH; however, supplemental intakes of vitamin D and calcium were associated with 25(OH)D3 after adjustment for age, sex, body composition, sun exposure, physical activity, and smoking. In addition, phosphate intake and the calcium-to-phosphate ratio were associated with iPTH after multiple adjustments. In a subgroup analysis, calcium and vitamin D supplements, as well as phosphate intake, were associated with 25(OH)D3 and/or iPTH in normal-weight subjects only. Our results indicate that habitual dietary vitamin D and calcium intakes have no independent effects on 25(OH)D3 or iPTH in elderly subjects without vitamin D deficiency, whereas phosphate intake and the calcium-to-phosphate ratio affect iPTH. However, vitamin D and calcium supplements may increase 25(OH)D3 and decrease iPTH, even during the summer, but the impact of supplements may depend on body mass index. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/23890356/Dietary_vitamin_D_intake_is_not_associated_with_25_hydroxyvitamin_D3_or_parathyroid_hormone_in_elderly_subjects_whereas_the_calcium_to_phosphate_ratio_affects_parathyroid_hormone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00121-8 DB - PRIME DP - Unbound Medicine ER -