Tags

Type your tag names separated by a space and hit enter

Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
Ann Epidemiol 2013; 23(9):571-5AE

Abstract

PURPOSE

Epidemiologic and experimental studies suggest that dietary fat intake may affect risk of pancreatic cancer, but published results are inconsistent.

METHODS

We examined risk associations for specific types of dietary fat intakes and related food sources among 111,416 participants in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We used Cox proportional hazards regression to examine associations between fat intake and pancreatic cancer risk.

RESULTS

Over a mean 8.4 years of follow-up, 411 pancreatic cancer cases were identified. We observed an inverse association between saturated fat intake and pancreatic cancer risk (hazard ratio [HR], 0.64 comparing extreme quintiles; 95% confidence interval [CI], 0.46-0.88), but the association became weaker and nonsignificant when individuals with fewer than 4 years of follow-up were excluded to avoid possible reverse causation (HR, 0.88; 95% CI, 0.58-1.33). Total fat intake showed a similar pattern of association, whereas intakes of monounsaturated and polyunsaturated fats and fats from animal or plant sources showed no associations with risk.

CONCLUSIONS

These results do not support the hypothesis of increased pancreatic cancer risk with higher fat consumption overall or by specific fat type or source. Dietary changes owing to undetected disease may explain the observed inverse association with saturated fat.

Authors+Show Affiliations

Department of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, CT, USA. aremhe2@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

23890797

Citation

Arem, Hannah, et al. "Dietary Fat Intake and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial." Annals of Epidemiology, vol. 23, no. 9, 2013, pp. 571-5.
Arem H, Mayne ST, Sampson J, et al. Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Ann Epidemiol. 2013;23(9):571-5.
Arem, H., Mayne, S. T., Sampson, J., Risch, H., & Stolzenberg-Solomon, R. Z. (2013). Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Annals of Epidemiology, 23(9), pp. 571-5. doi:10.1016/j.annepidem.2013.06.006.
Arem H, et al. Dietary Fat Intake and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Ann Epidemiol. 2013;23(9):571-5. PubMed PMID: 23890797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. AU - Arem,Hannah, AU - Mayne,Susan T, AU - Sampson,Joshua, AU - Risch,Harvey, AU - Stolzenberg-Solomon,Rachael Z, Y1 - 2013/07/23/ PY - 2012/11/01/received PY - 2013/05/16/revised PY - 2013/06/11/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2013/12/24/medline KW - Cohort studies KW - Dietary fats KW - Epidemiology KW - Pancreatic neoplasms SP - 571 EP - 5 JF - Annals of epidemiology JO - Ann Epidemiol VL - 23 IS - 9 N2 - PURPOSE: Epidemiologic and experimental studies suggest that dietary fat intake may affect risk of pancreatic cancer, but published results are inconsistent. METHODS: We examined risk associations for specific types of dietary fat intakes and related food sources among 111,416 participants in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We used Cox proportional hazards regression to examine associations between fat intake and pancreatic cancer risk. RESULTS: Over a mean 8.4 years of follow-up, 411 pancreatic cancer cases were identified. We observed an inverse association between saturated fat intake and pancreatic cancer risk (hazard ratio [HR], 0.64 comparing extreme quintiles; 95% confidence interval [CI], 0.46-0.88), but the association became weaker and nonsignificant when individuals with fewer than 4 years of follow-up were excluded to avoid possible reverse causation (HR, 0.88; 95% CI, 0.58-1.33). Total fat intake showed a similar pattern of association, whereas intakes of monounsaturated and polyunsaturated fats and fats from animal or plant sources showed no associations with risk. CONCLUSIONS: These results do not support the hypothesis of increased pancreatic cancer risk with higher fat consumption overall or by specific fat type or source. Dietary changes owing to undetected disease may explain the observed inverse association with saturated fat. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/23890797/Dietary_fat_intake_and_risk_of_pancreatic_cancer_in_the_Prostate_Lung_Colorectal_and_Ovarian_Cancer_Screening_Trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(13)00169-5 DB - PRIME DP - Unbound Medicine ER -