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Epidemiology of typical coronary heart disease versus heart disease of uncertain etiology (atypical) fatalities and their relationships with classic coronary risk factors.
Int J Cardiol. 2013 Oct 09; 168(4):3963-7.IJ

Abstract

OBJECTIVES

The relationships were explored of some cardiovascular risk factors to typical (TYP) and atypical (ATYP) fatal coronary events (CHD).

MATERIAL AND METHODS

Thirteen cohorts of 40-59 year-old men of the Seven Countries Study were followed-up for 40 years (N = 9704 heart disease free subjects). Fatal TYP-CHD were classified when manifested as myocardial infarction, other acute coronary syndromes, angina pectoris and sudden death; and as ATYP-CHD when manifested only as heart failure or arrhythmia in the absence of other clear etiologies. Death rates were computed for single countries separately for TYP and ATYP and for different lengths of follow-up. Cox models included: age, smoking habits, systolic blood pressure (SBP), serum cholesterol (CHOL), forced expiratory volume in ¾ sec (FEV) and diabetes.

RESULTS

TYP-CHD was more common in North American and Northern European countries, while ATYP-CHD were more common in Southern and Eastern Europe. Age at death was 5 years greater for ATYP-CHD than for TYP-CHD. Cox models in the pool of 13 cohorts showed that coefficient for age was significantly larger for ATYP-CHD (hazard ratio, HR: 2.36; confidence intervals CI: 2.18 - 2.26) versus TYP-CHD (HR 1.50, CI 1.43-1.58) while coefficients for CHOL was larger and significant for TYP-CHD (HR 1.29, CI 1.22-1.35) but not for ATYP-CHD (HR 0.93, CI 0.85-1.03). SBP, smoking habits, FEV and diabetes all predicted both conditions almost equally.

CONCLUSION

The different relationships of CHOL and age with the two types of fatal CHD suggest that the two groups of manifestations may belong to different diseases.

Authors+Show Affiliations

Association for Cardiac Research, Rome, Italy. Electronic address: menottia@tin.it.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23890869

Citation

Menotti, Alessandro, et al. "Epidemiology of Typical Coronary Heart Disease Versus Heart Disease of Uncertain Etiology (atypical) Fatalities and Their Relationships With Classic Coronary Risk Factors." International Journal of Cardiology, vol. 168, no. 4, 2013, pp. 3963-7.
Menotti A, Puddu PE, Lanti M, et al. Epidemiology of typical coronary heart disease versus heart disease of uncertain etiology (atypical) fatalities and their relationships with classic coronary risk factors. Int J Cardiol. 2013;168(4):3963-7.
Menotti, A., Puddu, P. E., Lanti, M., Kromhout, D., Tolonen, H., Parapid, B., Kircanski, B., Kafatos, A., & Adachi, H. (2013). Epidemiology of typical coronary heart disease versus heart disease of uncertain etiology (atypical) fatalities and their relationships with classic coronary risk factors. International Journal of Cardiology, 168(4), 3963-7. https://doi.org/10.1016/j.ijcard.2013.06.143
Menotti A, et al. Epidemiology of Typical Coronary Heart Disease Versus Heart Disease of Uncertain Etiology (atypical) Fatalities and Their Relationships With Classic Coronary Risk Factors. Int J Cardiol. 2013 Oct 9;168(4):3963-7. PubMed PMID: 23890869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of typical coronary heart disease versus heart disease of uncertain etiology (atypical) fatalities and their relationships with classic coronary risk factors. AU - Menotti,Alessandro, AU - Puddu,Paolo Emilio, AU - Lanti,Mariapaola, AU - Kromhout,Daan, AU - Tolonen,Hanna, AU - Parapid,Biljana, AU - Kircanski,Bratislav, AU - Kafatos,Antony, AU - Adachi,Hisashi, Y1 - 2013/07/25/ PY - 2013/02/05/received PY - 2013/06/25/revised PY - 2013/06/30/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2015/1/27/medline KW - Atypical coronary heart disease KW - Epidemiology KW - Risk factors KW - Typical coronary heart disease SP - 3963 EP - 7 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 168 IS - 4 N2 - OBJECTIVES: The relationships were explored of some cardiovascular risk factors to typical (TYP) and atypical (ATYP) fatal coronary events (CHD). MATERIAL AND METHODS: Thirteen cohorts of 40-59 year-old men of the Seven Countries Study were followed-up for 40 years (N = 9704 heart disease free subjects). Fatal TYP-CHD were classified when manifested as myocardial infarction, other acute coronary syndromes, angina pectoris and sudden death; and as ATYP-CHD when manifested only as heart failure or arrhythmia in the absence of other clear etiologies. Death rates were computed for single countries separately for TYP and ATYP and for different lengths of follow-up. Cox models included: age, smoking habits, systolic blood pressure (SBP), serum cholesterol (CHOL), forced expiratory volume in ¾ sec (FEV) and diabetes. RESULTS: TYP-CHD was more common in North American and Northern European countries, while ATYP-CHD were more common in Southern and Eastern Europe. Age at death was 5 years greater for ATYP-CHD than for TYP-CHD. Cox models in the pool of 13 cohorts showed that coefficient for age was significantly larger for ATYP-CHD (hazard ratio, HR: 2.36; confidence intervals CI: 2.18 - 2.26) versus TYP-CHD (HR 1.50, CI 1.43-1.58) while coefficients for CHOL was larger and significant for TYP-CHD (HR 1.29, CI 1.22-1.35) but not for ATYP-CHD (HR 0.93, CI 0.85-1.03). SBP, smoking habits, FEV and diabetes all predicted both conditions almost equally. CONCLUSION: The different relationships of CHOL and age with the two types of fatal CHD suggest that the two groups of manifestations may belong to different diseases. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/23890869/Epidemiology_of_typical_coronary_heart_disease_versus_heart_disease_of_uncertain_etiology__atypical__fatalities_and_their_relationships_with_classic_coronary_risk_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(13)01229-1 DB - PRIME DP - Unbound Medicine ER -