TY - JOUR T1 - Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease. AU - Santos-García,Diego, AU - de la Fuente-Fernández,Raúl, Y1 - 2013/07/25/ PY - 2013/05/04/received PY - 2013/06/28/revised PY - 2013/07/08/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2014/3/14/medline KW - 39-item Parkinson's disease Quality of Life Questionnaire Summary Index score KW - ADLS KW - Activities of Daily Living Scale KW - BDI KW - Beck Depression Inventory KW - DBS KW - Health-related quality of life KW - Hoehn and Yahr KW - H–Y KW - ICC KW - Mood KW - Motor fluctuations KW - NMS KW - NMSS KW - Non-Motor Symptoms Scale KW - Non-motor symptoms KW - PD KW - PDQ-39SI KW - PQ-10 KW - Parkinson's disease KW - Perceived quality of life KW - QoL KW - STN KW - UPDRS KW - Unified Parkinson's Disease Rating Scale KW - deep brain stimulation KW - intraclass correlation coefficient KW - non-motor symptoms KW - perceived quality of life KW - quality of life KW - subthalamic nucleus SP - 136 EP - 40 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 332 IS - 1-2 N2 - OBJECTIVE: To investigate the impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease (PD). METHODS: One hundred and fifty PD patients (57.3% males; 70.9±8.6years old) were included in this cross-sectional, monocenter, evaluation study. Multiple linear regression methods were used to evaluate the direct impact of non-motor symptoms (as assessed by the Non-Motor Symptoms Scale [NMSS]) on 1) the 39-item PD Quality of Life Questionnaire Summary Index score (PDQ-39SI), and 2) a subjective assessment of perceived quality of life (PQ-10), after adjusting for age, sex, mood (Beck Depression Inventory), disability (Schwab&England Activities of Daily Living Scale), and PD-specific motor dysfunction (ON-state Hoehn&Yahr/Unified Parkinson's Disease Rating Scale [UPDRS] part III, and motor complications [UPDRS part IV]). RESULTS: Higher NMSS total scores were systematically associated with worse quality of life (for PDQ-39SI, p=0.013; for PQ-10, p=0.017). PD-specific motor dysfunction had a larger negative impact on health-related quality of life (PDQ-39SI) than non-motor symptoms (2.8% vs 0.7%). In contrast, the negative impact of non-motor symptoms on perceived quality of life (PQ-10) was larger than that found for PD-specific motor dysfunction (2.8% vs 0.9%). While the model for PDQ-39SI provided an adequate fit (adjusted R-squared, 0.83), a substantial proportion of the PQ-10 variance remained unexplained (adjusted R-squared, 0.48). CONCLUSIONS: Non-motor symptoms have a direct negative impact on health-related and perceived quality of life in PD. Perceived quality of life is not adequately explained by motor and non-motor manifestations of the disease. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/23890935/Impact_of_non_motor_symptoms_on_health_related_and_perceived_quality_of_life_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(13)00316-X DB - PRIME DP - Unbound Medicine ER -