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Population-based cohort study on the increase in the risk for type 2 diabetes mellitus development from nonapnea sleep disorders.
Sleep Med. 2013 Sep; 14(9):913-8.SM

Abstract

OBJECTIVES

The evidence concerning the relationship between nonapnea sleep disorders and the risk for type 2 diabetes mellitus (DM) is scant and elusive. Our study aimed to examine if nonapnea sleep disorders increase the risk for DM using a population-based retrospective cohort study from 1997 to 2010.

METHODS

In the Taiwan's National Health Insurance Research Database (NHIRD), 45,602 patients with nonapnea sleep disorders were identified as the study cohort. The comparison cohort was formed by 91,204 age- and gender-matched controls. Cox proportional hazards regression model was used to estimate the risk for developing DM.

RESULTS

In 45,602 patients with nonapnea sleep disorders, 7241 new cases of DM were reported during the follow-up period. The mean follow-up time was 9.04 (standard deviation [SD], 3.33) and 8.96 (SD, 3.47) for the nonapnea sleep disorders cohort and the comparison cohort, respectively. The incidence rate of DM was higher in the nonapnea sleep disorder cohort than in the comparison cohort (17.6 vs 13.3 per 1000 individuals-years). Overall, patients with nonapnea sleep disorders had a higher risk for DM compared to patients without nonapnea sleep disorders (adjusted hazard ratio [HR], 1.05 [95% confidence interval {CI}, 1.02-1.08]). Men with nonapnea sleep disorders had a higher risk for DM than the men in the comparison group (adjusted HR, 1.08 [95% CI, 1.03-1.14]). Among subjects aged less than 40years, patients with nonapnea sleep disorders had a higher risk for DM than the comparison group (adjusted HR, 1.42 [95% CI, 1.27-1.59]). Compared with the comparison cohort, patients with sleep disturbance had an 11% higher risk for DM (adjusted HR, 1.11 [95% CI, 1.07-1.16]).

CONCLUSION

Compared to patients without nonapnea sleep disorders, patients with nonapnea sleep disorders had a higher risk for developing DM, especially among those who were less than 40years of age and who had sleep disturbances.

Authors+Show Affiliations

Department of Internal Medicine, Puli Branch of Taichung Veterans General Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23890955

Citation

Lai, Yun-Ju, et al. "Population-based Cohort Study On the Increase in the Risk for Type 2 Diabetes Mellitus Development From Nonapnea Sleep Disorders." Sleep Medicine, vol. 14, no. 9, 2013, pp. 913-8.
Lai YJ, Lin CL, Lin MC, et al. Population-based cohort study on the increase in the risk for type 2 diabetes mellitus development from nonapnea sleep disorders. Sleep Med. 2013;14(9):913-8.
Lai, Y. J., Lin, C. L., Lin, M. C., Lee, S. T., Sung, F. C., Chang, Y. J., & Kao, C. H. (2013). Population-based cohort study on the increase in the risk for type 2 diabetes mellitus development from nonapnea sleep disorders. Sleep Medicine, 14(9), 913-8. https://doi.org/10.1016/j.sleep.2013.03.024
Lai YJ, et al. Population-based Cohort Study On the Increase in the Risk for Type 2 Diabetes Mellitus Development From Nonapnea Sleep Disorders. Sleep Med. 2013;14(9):913-8. PubMed PMID: 23890955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Population-based cohort study on the increase in the risk for type 2 diabetes mellitus development from nonapnea sleep disorders. AU - Lai,Yun-Ju, AU - Lin,Cheng-Li, AU - Lin,Ming-Chia, AU - Lee,Shih-Tan, AU - Sung,Fung-Chang, AU - Chang,Yen-Jung, AU - Kao,Chia-Hung, Y1 - 2013/07/25/ PY - 2012/12/18/received PY - 2013/03/05/revised PY - 2013/03/21/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2014/5/13/medline KW - Cohort study KW - Diabetes mellitus KW - Diabetic risk KW - Insomnia KW - Nonapnea sleep disorders KW - Sleep disturbance SP - 913 EP - 8 JF - Sleep medicine JO - Sleep Med VL - 14 IS - 9 N2 - OBJECTIVES: The evidence concerning the relationship between nonapnea sleep disorders and the risk for type 2 diabetes mellitus (DM) is scant and elusive. Our study aimed to examine if nonapnea sleep disorders increase the risk for DM using a population-based retrospective cohort study from 1997 to 2010. METHODS: In the Taiwan's National Health Insurance Research Database (NHIRD), 45,602 patients with nonapnea sleep disorders were identified as the study cohort. The comparison cohort was formed by 91,204 age- and gender-matched controls. Cox proportional hazards regression model was used to estimate the risk for developing DM. RESULTS: In 45,602 patients with nonapnea sleep disorders, 7241 new cases of DM were reported during the follow-up period. The mean follow-up time was 9.04 (standard deviation [SD], 3.33) and 8.96 (SD, 3.47) for the nonapnea sleep disorders cohort and the comparison cohort, respectively. The incidence rate of DM was higher in the nonapnea sleep disorder cohort than in the comparison cohort (17.6 vs 13.3 per 1000 individuals-years). Overall, patients with nonapnea sleep disorders had a higher risk for DM compared to patients without nonapnea sleep disorders (adjusted hazard ratio [HR], 1.05 [95% confidence interval {CI}, 1.02-1.08]). Men with nonapnea sleep disorders had a higher risk for DM than the men in the comparison group (adjusted HR, 1.08 [95% CI, 1.03-1.14]). Among subjects aged less than 40years, patients with nonapnea sleep disorders had a higher risk for DM than the comparison group (adjusted HR, 1.42 [95% CI, 1.27-1.59]). Compared with the comparison cohort, patients with sleep disturbance had an 11% higher risk for DM (adjusted HR, 1.11 [95% CI, 1.07-1.16]). CONCLUSION: Compared to patients without nonapnea sleep disorders, patients with nonapnea sleep disorders had a higher risk for developing DM, especially among those who were less than 40years of age and who had sleep disturbances. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/23890955/Population_based_cohort_study_on_the_increase_in_the_risk_for_type_2_diabetes_mellitus_development_from_nonapnea_sleep_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(13)00212-8 DB - PRIME DP - Unbound Medicine ER -