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Chalcone derivatives from the fern Cyclosorus parasiticus and their anti-proliferative activity.
Food Chem Toxicol. 2013 Oct; 60:147-52.FC

Abstract

Three new chalcone derivatives, named parasiticins A-C (1-3), were isolated from the leaves of Cyclosorus parasiticus, together with four known chalcones, 5,7-dihydroxy-4-phenyl-8-(3-phenyl-trans-acryloyl)-3,4-dihydro-1-benzopyran-2-one (4), 2'-hydroxy-4',6'-dimethoxychalcone (5), 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (6), 2',4'-dihydroxy-6'-methoxy-3'-methylchalcone (7). The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of compounds 1-7 were evaluated against six human cancer cell lines in vitro. Compounds 3 and 6 exhibited substantial cytotoxicity against all six cell lines, especially toward HepG2 with the IC₅₀ values of 1.60 and 2.82 μM, respectively. Furthermore, we demonstrated that compounds 3 and 6 could induce apoptosis in the HepG2 cell line, which may contribute significantly to their cytotoxicity.

Authors+Show Affiliations

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China; Innovation Institute, Huazhong University of Science and Technology, Wuhan 430074, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23891701

Citation

Wei, Han, et al. "Chalcone Derivatives From the Fern Cyclosorus Parasiticus and Their Anti-proliferative Activity." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 60, 2013, pp. 147-52.
Wei H, Zhang X, Wu G, et al. Chalcone derivatives from the fern Cyclosorus parasiticus and their anti-proliferative activity. Food Chem Toxicol. 2013;60:147-52.
Wei, H., Zhang, X., Wu, G., Yang, X., Pan, S., Wang, Y., & Ruan, J. (2013). Chalcone derivatives from the fern Cyclosorus parasiticus and their anti-proliferative activity. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 60, 147-52. https://doi.org/10.1016/j.fct.2013.07.045
Wei H, et al. Chalcone Derivatives From the Fern Cyclosorus Parasiticus and Their Anti-proliferative Activity. Food Chem Toxicol. 2013;60:147-52. PubMed PMID: 23891701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chalcone derivatives from the fern Cyclosorus parasiticus and their anti-proliferative activity. AU - Wei,Han, AU - Zhang,Xuenong, AU - Wu,Guanghua, AU - Yang,Xian, AU - Pan,Songwei, AU - Wang,Yanyan, AU - Ruan,Jinlan, Y1 - 2013/07/26/ PY - 2013/05/18/received PY - 2013/07/14/revised PY - 2013/07/17/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2014/5/6/medline KW - Anti-proliferative activity KW - Chalcone KW - Cyclosorus parasiticus KW - HepG2 cell SP - 147 EP - 52 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 60 N2 - Three new chalcone derivatives, named parasiticins A-C (1-3), were isolated from the leaves of Cyclosorus parasiticus, together with four known chalcones, 5,7-dihydroxy-4-phenyl-8-(3-phenyl-trans-acryloyl)-3,4-dihydro-1-benzopyran-2-one (4), 2'-hydroxy-4',6'-dimethoxychalcone (5), 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (6), 2',4'-dihydroxy-6'-methoxy-3'-methylchalcone (7). The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of compounds 1-7 were evaluated against six human cancer cell lines in vitro. Compounds 3 and 6 exhibited substantial cytotoxicity against all six cell lines, especially toward HepG2 with the IC₅₀ values of 1.60 and 2.82 μM, respectively. Furthermore, we demonstrated that compounds 3 and 6 could induce apoptosis in the HepG2 cell line, which may contribute significantly to their cytotoxicity. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23891701/Chalcone_derivatives_from_the_fern_Cyclosorus_parasiticus_and_their_anti_proliferative_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(13)00500-0 DB - PRIME DP - Unbound Medicine ER -