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In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats.
Food Chem Toxicol. 2013 Oct; 60:135-40.FC

Abstract

The present study was undertaken to evaluate the in vitro antioxidant and antihyperlipidemic activity of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet-induced hyperlipidemic rats. In in vitro studies T. asiatica leaves ethyl acetate extract showed very good scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC₅₀ 605.34±2.62 μg/ml), hydroxyl (IC₅₀ 694.37±2.12 μg/ml) and nitric oxide (IC₅₀ 897.83±1.48 μg/ml) radicals, as well as high reducing power. In Triton WR-1339 induced hyperlipidemic rats, oral treatment with T. asiatica leaves ethyl acetate extract produced a significant (P≤0.005) decrease in the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and significant increase in high-density lipoprotein cholesterol (HDL-C) in comparison with hexane and methanol extracts. In high fat diet-fed hyperlipidemic rats, the ethyl acetate extract (200 and 400 mg/kg) significantly altered the plasma and liver lipids levels to near normal.

Authors+Show Affiliations

Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23891761

Citation

Irudayaraj, Santiagu Stephen, et al. "In Vitro Antioxidant and Antihyperlipidemic Activities of Toddalia Asiatica (L) Lam. Leaves in Triton WR-1339 and High Fat Diet Induced Hyperlipidemic Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 60, 2013, pp. 135-40.
Irudayaraj SS, Sunil C, Duraipandiyan V, et al. In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats. Food Chem Toxicol. 2013;60:135-40.
Irudayaraj, S. S., Sunil, C., Duraipandiyan, V., & Ignacimuthu, S. (2013). In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 60, 135-40. https://doi.org/10.1016/j.fct.2013.07.035
Irudayaraj SS, et al. In Vitro Antioxidant and Antihyperlipidemic Activities of Toddalia Asiatica (L) Lam. Leaves in Triton WR-1339 and High Fat Diet Induced Hyperlipidemic Rats. Food Chem Toxicol. 2013;60:135-40. PubMed PMID: 23891761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats. AU - Irudayaraj,Santiagu Stephen, AU - Sunil,Christudas, AU - Duraipandiyan,Veeramuthu, AU - Ignacimuthu,Savarimuthu, Y1 - 2013/07/25/ PY - 2012/10/31/received PY - 2013/06/09/revised PY - 2013/07/12/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2014/5/6/medline KW - Antioxidant KW - Fenofibrate KW - High-fat diet KW - Hyperlipidemia KW - Toddalia asiatica KW - Triton WR-1339 SP - 135 EP - 40 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 60 N2 - The present study was undertaken to evaluate the in vitro antioxidant and antihyperlipidemic activity of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet-induced hyperlipidemic rats. In in vitro studies T. asiatica leaves ethyl acetate extract showed very good scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC₅₀ 605.34±2.62 μg/ml), hydroxyl (IC₅₀ 694.37±2.12 μg/ml) and nitric oxide (IC₅₀ 897.83±1.48 μg/ml) radicals, as well as high reducing power. In Triton WR-1339 induced hyperlipidemic rats, oral treatment with T. asiatica leaves ethyl acetate extract produced a significant (P≤0.005) decrease in the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and significant increase in high-density lipoprotein cholesterol (HDL-C) in comparison with hexane and methanol extracts. In high fat diet-fed hyperlipidemic rats, the ethyl acetate extract (200 and 400 mg/kg) significantly altered the plasma and liver lipids levels to near normal. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23891761/In_vitro_antioxidant_and_antihyperlipidemic_activities_of_Toddalia_asiatica__L__Lam__leaves_in_Triton_WR_1339_and_high_fat_diet_induced_hyperlipidemic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(13)00490-0 DB - PRIME DP - Unbound Medicine ER -