Tags

Type your tag names separated by a space and hit enter

Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy.
Drug Discov Today. 2014 Mar; 19(3):295-304.DD

Abstract

The endocannabinoid system is implicated in, and regulates, several physiological processes, ranging from food intake and energy balance to pain and inflammation. 2-Arachidonoylglycerol (2-AG) is a full agonist at the cannabinoid receptors which classically mediate its effects. The activity of this bioactive lipid is dependent on its endogenous levels, which are tightly controlled by several hydrolases, monoacylglycerol lipase and α/β-hydrolase domain 6 and 12. Moreover, 2-AG is also a substrate of cyclooxygenase-2, and this reaction leads to the formation of prostaglandin glycerol esters, the effects of which remain to be fully elucidated. In this review we discuss the multiple mechanisms by which 2-AG controls inflammation and the therapeutic potential of 2-AG metabolism inhibitors.

Authors+Show Affiliations

Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Av. E. Mounier 72, B1.72.01, B-1200 Bruxelles, Belgium; Medicinal Chemistry Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Av. E. Mounier 73, B1.73.10, B-1200 Bruxelles, Belgium.Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Av. E. Mounier 72, B1.72.01, B-1200 Bruxelles, Belgium.Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Av. E. Mounier 72, B1.72.01, B-1200 Bruxelles, Belgium. Electronic address: giulio.muccioli@uclouvain.be.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23891880

Citation

Alhouayek, Mireille, et al. "Controlling 2-arachidonoylglycerol Metabolism as an Anti-inflammatory Strategy." Drug Discovery Today, vol. 19, no. 3, 2014, pp. 295-304.
Alhouayek M, Masquelier J, Muccioli GG. Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. Drug Discov Today. 2014;19(3):295-304.
Alhouayek, M., Masquelier, J., & Muccioli, G. G. (2014). Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. Drug Discovery Today, 19(3), 295-304. https://doi.org/10.1016/j.drudis.2013.07.009
Alhouayek M, Masquelier J, Muccioli GG. Controlling 2-arachidonoylglycerol Metabolism as an Anti-inflammatory Strategy. Drug Discov Today. 2014;19(3):295-304. PubMed PMID: 23891880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. AU - Alhouayek,Mireille, AU - Masquelier,Julien, AU - Muccioli,Giulio G, Y1 - 2013/07/23/ PY - 2013/04/20/received PY - 2013/07/03/revised PY - 2013/07/15/accepted PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2015/4/7/medline SP - 295 EP - 304 JF - Drug discovery today JO - Drug Discov Today VL - 19 IS - 3 N2 - The endocannabinoid system is implicated in, and regulates, several physiological processes, ranging from food intake and energy balance to pain and inflammation. 2-Arachidonoylglycerol (2-AG) is a full agonist at the cannabinoid receptors which classically mediate its effects. The activity of this bioactive lipid is dependent on its endogenous levels, which are tightly controlled by several hydrolases, monoacylglycerol lipase and α/β-hydrolase domain 6 and 12. Moreover, 2-AG is also a substrate of cyclooxygenase-2, and this reaction leads to the formation of prostaglandin glycerol esters, the effects of which remain to be fully elucidated. In this review we discuss the multiple mechanisms by which 2-AG controls inflammation and the therapeutic potential of 2-AG metabolism inhibitors. SN - 1878-5832 UR - https://www.unboundmedicine.com/medline/citation/23891880/Controlling_2_arachidonoylglycerol_metabolism_as_an_anti_inflammatory_strategy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1359-6446(13)00243-2 DB - PRIME DP - Unbound Medicine ER -