TY - JOUR T1 - The impact of the Mukaiyama aldol reaction in total synthesis. AU - Kan,S B Jennifer, AU - Ng,Kenneth K-H, AU - Paterson,Ian, Y1 - 2013/07/26/ PY - 2013/05/07/received PY - 2013/7/30/entrez PY - 2013/7/31/pubmed PY - 2014/3/13/medline KW - aldol reaction KW - enolates KW - natural products KW - polyketides KW - stereocontrol SP - 9097 EP - 108 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 52 IS - 35 N2 - Four decades since Mukaiyama's first reports on the successful application of silicon and boron enolates in directed aldol reactions, the ability of this highly controlled carbon-carbon bond-forming method to simultaneously define stereochemistry, introduce complexity, and construct the carbon skeleton with a characteristic 1,3-oxygenation pattern has made it a powerful tool for natural product synthesis. This Minireview highlights a number of representative total syntheses that demonstrate the impact of the Mukaiyama aldol reaction and discusses the underlying mechanistic rationale that determines the stereochemical outcomes. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/23893491/The_impact_of_the_Mukaiyama_aldol_reaction_in_total_synthesis_ L2 - https://doi.org/10.1002/anie.201303914 DB - PRIME DP - Unbound Medicine ER -