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Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function.
Biochimie. 2013 Nov; 95(11):1971-9.B

Abstract

Ectopic lipid accumulation is now known to be a mechanism that contributes to organ injury in the context of metabolic diseases. In muscle and liver, accumulation of lipids impairs insulin signaling. This hypothesis accounts for the mechanism of insulin resistance in obesity, type 2 diabetes, aging and lipodystrophy. Increasing data suggest that lipid accumulation in the kidneys could also contribute to the alteration of kidney function in the context of metabolic syndrome and obesity. Furthermore and more unexpectedly, animal models of kidney disease exhibit a decreased adiposity and ectopic lipid redistribution suggesting that kidney disease may be a state of lipodystrophy. However, whether this abnormal lipid partitioning during chronic kidney disease (CKD) may have any functional impact in these tissues needs to be investigated. Here, we provide a perspective by defining the problem and analyzing the possible causes and consequences. Further human studies are required to strengthen these observations, and provide novel therapeutic approaches.

Authors+Show Affiliations

Université de Lyon, INSERM U1060, CarMeN, INSA de Lyon, Univ Lyon-1, F-69621 Villeurbanne, France; Hospices Civils de Lyon, Department of Nephrology, Hôpital E Herriot, Lyon F-69003, France. Electronic address: fitsum.guebre-egziabher@chu-lyon.fr.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23896376

Citation

Guebre-Egziabher, Fitsum, et al. "Ectopic Lipid Accumulation: a Potential Cause for Metabolic Disturbances and a Contributor to the Alteration of Kidney Function." Biochimie, vol. 95, no. 11, 2013, pp. 1971-9.
Guebre-Egziabher F, Alix PM, Koppe L, et al. Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function. Biochimie. 2013;95(11):1971-9.
Guebre-Egziabher, F., Alix, P. M., Koppe, L., Pelletier, C. C., Kalbacher, E., Fouque, D., & Soulage, C. O. (2013). Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function. Biochimie, 95(11), 1971-9. https://doi.org/10.1016/j.biochi.2013.07.017
Guebre-Egziabher F, et al. Ectopic Lipid Accumulation: a Potential Cause for Metabolic Disturbances and a Contributor to the Alteration of Kidney Function. Biochimie. 2013;95(11):1971-9. PubMed PMID: 23896376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function. AU - Guebre-Egziabher,Fitsum, AU - Alix,Pascaline M, AU - Koppe,Laetitia, AU - Pelletier,Caroline C, AU - Kalbacher,Emilie, AU - Fouque,Denis, AU - Soulage,Christophe O, Y1 - 2013/07/27/ PY - 2013/04/29/received PY - 2013/07/18/accepted PY - 2013/7/31/entrez PY - 2013/7/31/pubmed PY - 2014/5/16/medline KW - ACC KW - AMP-activated protein kinase KW - AMPK KW - ATMs KW - BMI KW - C/EBP-α KW - CCAAT/enhancer binding protein alpha KW - CKD KW - CPT-1 KW - ChREBP KW - Chronic kidney disease KW - DAG KW - DN KW - Diacylglycerols KW - ER KW - FA KW - FA-coA KW - FABP-4 KW - FAS KW - FSP27 KW - GLUT-4 KW - HOMA-IR KW - IKK-β KW - IRS-1/2 KW - Insulin resistance KW - JNK KW - LPS KW - Lipodystrophy KW - Lipotoxicity KW - MMPC KW - Met-S KW - NAFLD KW - NEFA KW - NFκB KW - PAMPs KW - PKB/Akt KW - PKC-ε KW - PKC-θ KW - PPAR-αperoxisome KW - PPAR-γperoxisome KW - ROS KW - SFA KW - SREBP-1 KW - TLR-2 KW - TLR-4 KW - Toll-like receptor 2 KW - Toll-like receptor 4 KW - UPR KW - WAT KW - acetyl-coA carboxylase KW - adipose tissue macrophages KW - body mass index KW - c-jun N-terminal kinase KW - carbohydrate response element binding protein KW - carnitine palmitoyl transferase-1 KW - chronic kidney disease KW - diabetic nephropathy KW - diacylglycerols KW - endoplasmic reticulum KW - fat specific protein 27 KW - fatty acid binding protein-4 KW - fatty acid synthase KW - fatty acids KW - fatty acyl-Co-enzyme A KW - glucose transporter type 4 KW - homeostatic model assessment of insulin resistance KW - inhibitor of nuclear factor kappa-B kinase beta KW - insulin receptor substrates 1 and 2 KW - lipopolysaccharide KW - metabolic syndrome KW - multipotent mesenchymal progenitor cells KW - non-alcoholic fatty liver disease KW - non-esterified fatty acids KW - nuclear factor kappa-B KW - pathogen-associated molecular patterns KW - proliferator-activated receptor alpha KW - proliferator-activated receptor gamma KW - protein kinase B/Akt KW - protein kinase C epsilon KW - protein kinase C theta KW - reactive oxygen species KW - saturated fatty acids KW - sterol regulatory element binding protein-1 KW - unfolded protein response KW - white adipose tissue SP - 1971 EP - 9 JF - Biochimie JO - Biochimie VL - 95 IS - 11 N2 - Ectopic lipid accumulation is now known to be a mechanism that contributes to organ injury in the context of metabolic diseases. In muscle and liver, accumulation of lipids impairs insulin signaling. This hypothesis accounts for the mechanism of insulin resistance in obesity, type 2 diabetes, aging and lipodystrophy. Increasing data suggest that lipid accumulation in the kidneys could also contribute to the alteration of kidney function in the context of metabolic syndrome and obesity. Furthermore and more unexpectedly, animal models of kidney disease exhibit a decreased adiposity and ectopic lipid redistribution suggesting that kidney disease may be a state of lipodystrophy. However, whether this abnormal lipid partitioning during chronic kidney disease (CKD) may have any functional impact in these tissues needs to be investigated. Here, we provide a perspective by defining the problem and analyzing the possible causes and consequences. Further human studies are required to strengthen these observations, and provide novel therapeutic approaches. SN - 1638-6183 UR - https://www.unboundmedicine.com/medline/citation/23896376/Ectopic_lipid_accumulation:_A_potential_cause_for_metabolic_disturbances_and_a_contributor_to_the_alteration_of_kidney_function_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-9084(13)00239-3 DB - PRIME DP - Unbound Medicine ER -