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Cardiac amyloidosis masquerading as biventricular hypertrophy in a patient with multiple myeloma.
BMJ Case Rep. 2013 Jul 29; 2013BC

Abstract

Cardiac amyloidosis or amyloid cardiomyopathy is a rare disorder characterised by extracellular deposition of insoluble polymers composed of low-molecular-weight subunit proteins within the myocardium. This often results in an infiltrative cardiomyopathy with restrictive pathophysiology, leading to progressive heart failure. In this report, we present an interesting case of cardiac amyloidosis that eventually led to the diagnosis of underlying multiple myeloma in a patient with no previous cardiac history. Cardiac amyloidosis should be suspected in patients with unexplained congestive heart-failure symptoms accompanied by low-voltage complexes on ECG, preserved ejection fraction with asymmetric ventricular hypertrophy and abnormal myocardial texture, described as 'granular sparkling' on echocardiogram. Patients with cardiac amyloidosis should be closely monitored as mortality remains high, despite advances in treatment.

Authors+Show Affiliations

Hurley Medical Center, Flint, Michigan, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23897372

Citation

Basha, Haseeb Ilias, et al. "Cardiac Amyloidosis Masquerading as Biventricular Hypertrophy in a Patient With Multiple Myeloma." BMJ Case Reports, vol. 2013, 2013.
Basha HI, Raj E, Bachuwa G. Cardiac amyloidosis masquerading as biventricular hypertrophy in a patient with multiple myeloma. BMJ Case Rep. 2013;2013.
Basha, H. I., Raj, E., & Bachuwa, G. (2013). Cardiac amyloidosis masquerading as biventricular hypertrophy in a patient with multiple myeloma. BMJ Case Reports, 2013. https://doi.org/10.1136/bcr-2012-008113
Basha HI, Raj E, Bachuwa G. Cardiac Amyloidosis Masquerading as Biventricular Hypertrophy in a Patient With Multiple Myeloma. BMJ Case Rep. 2013 Jul 29;2013 PubMed PMID: 23897372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac amyloidosis masquerading as biventricular hypertrophy in a patient with multiple myeloma. AU - Basha,Haseeb Ilias, AU - Raj,Ethiraj, AU - Bachuwa,Ghassan, Y1 - 2013/07/29/ PY - 2013/7/31/entrez PY - 2013/7/31/pubmed PY - 2013/10/18/medline JF - BMJ case reports JO - BMJ Case Rep VL - 2013 N2 - Cardiac amyloidosis or amyloid cardiomyopathy is a rare disorder characterised by extracellular deposition of insoluble polymers composed of low-molecular-weight subunit proteins within the myocardium. This often results in an infiltrative cardiomyopathy with restrictive pathophysiology, leading to progressive heart failure. In this report, we present an interesting case of cardiac amyloidosis that eventually led to the diagnosis of underlying multiple myeloma in a patient with no previous cardiac history. Cardiac amyloidosis should be suspected in patients with unexplained congestive heart-failure symptoms accompanied by low-voltage complexes on ECG, preserved ejection fraction with asymmetric ventricular hypertrophy and abnormal myocardial texture, described as 'granular sparkling' on echocardiogram. Patients with cardiac amyloidosis should be closely monitored as mortality remains high, despite advances in treatment. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/23897372/Cardiac_amyloidosis_masquerading_as_biventricular_hypertrophy_in_a_patient_with_multiple_myeloma_ L2 - https://casereports.bmj.com/cgi/pmidlookup?view=long&pmid=23897372 DB - PRIME DP - Unbound Medicine ER -