TY - JOUR T1 - A material-sparing method for assessment of powder deformation characteristics using data collected during a single compression-decompression cycle. AU - Katz,Jeffrey M, AU - Roopwani,Rahul, AU - Buckner,Ira S, Y1 - 2013/07/29/ PY - 2013/03/02/received PY - 2013/05/26/revised PY - 2013/07/03/accepted PY - 2013/7/31/entrez PY - 2013/7/31/pubmed PY - 2014/3/29/medline KW - compaction KW - compression KW - materials science KW - mechanical properties KW - porosity KW - solid dosage form KW - tablet KW - tableting SP - 3687 EP - 93 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 102 IS - 10 N2 - Compressibility profiles, or functions of solid fraction versus applied pressure, are used to provide insight into the fundamental mechanical behavior of powders during compaction. These functions, collected during compression (in-die) or post ejection (out-of-die), indicate the amount of pressure that a given powder formulation requires to be compressed to a given density or thickness. To take advantage of the benefits offered by both methods, the data collected in-die during a single compression-decompression cycle will be used to generate the equivalent of a complete out-of-die compressibility profile that has been corrected for both elastic and viscoelastic recovery of the powder. This method has been found to be both a precise and accurate means of evaluating out-of-die compressibility for four common tableting excipients. Using this method, a comprehensive characterization of powder compaction behavior, specifically in relation to plastic/brittle, elastic and viscoelastic deformation, can be obtained. Not only is the method computationally simple, but it is also material-sparing. The ability to characterize powder compressibility using this approach can improve productivity and streamline tablet development studies. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/23897398/A_material_sparing_method_for_assessment_of_powder_deformation_characteristics_using_data_collected_during_a_single_compression_decompression_cycle_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(15)30883-2 DB - PRIME DP - Unbound Medicine ER -