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Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies.
Ann Rheum Dis. 2014 Nov; 73(11):1962-7.AR

Abstract

OBJECTIVE

To summarise the evidence regarding the dose-response association between alcohol consumption and risk of rheumatoid arthritis (RA).

METHOD

Studies were identified from search of MEDLINE, Embase and Web of Science databases between 1 January 1946 and 10 April 2013, and from review of the conference abstracts and the reference lists of retrieved articles. Prospective studies that reported relative risks (RRs) with 95% CIs for the association between alcohol consumption and the risk of RA were included. Results from individual studies were pooled using a dose-response meta-analysis.

RESULTS

Up to 10 April 2013, 8 prospective studies contained 195 029 participants and 1878 RA cases were included. The results indicated that low to moderate alcohol consumption yielded a preventive effect on RA development (RR: 0.86; 95% CI 0.78 to 0.94), and provided some evidence of a non-linear relationship between alcohol consumption and risk of RA. Dose-response meta-analysis of the study data revealed that compared with that for no alcohol consumption, the adjusted RR was 0.93 (95% CI 0.88 to 0.98) for 3 g/day of alcohol consumption, 0.86 (95% CI 0.76 to 0.97) for 9 g/day, 0.88 (95% CI 0.78 to 0.99) for 12 g/day, 0.91 (95% CI 0.81 to 1.03) for 15 g/day, and 1.28 (95% CI 0.94 to 1.73) for 30 g/day. Subgroup analysis indicated that women who had low to moderate alcohol consumption had a 19% reduction in RA risk. Regardless of sex, a consistent low to moderate alcohol consumption for a period of at least 10 years was found to have a 17% reduction in RA risk.

CONCLUSIONS

Low to moderate alcohol consumption inversely associated with the development of RA in a manner that appears to be dose-dependent, time-dependent and sex-dependent. Large prospective studies that investigate gene-environment interactions are required to further clarify the aetiology of RA.

Authors+Show Affiliations

Department of Health Statistics, Second Military Medical University, Shanghai, China.Department of Health Statistics, Second Military Medical University, Shanghai, China.Department of Rheumatology and Immunology, Changhai Hospital, Shanghai, China.Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.Department of Health Statistics, Second Military Medical University, Shanghai, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23897767

Citation

Jin, Zhichao, et al. "Alcohol Consumption as a Preventive Factor for Developing Rheumatoid Arthritis: a Dose-response Meta-analysis of Prospective Studies." Annals of the Rheumatic Diseases, vol. 73, no. 11, 2014, pp. 1962-7.
Jin Z, Xiang C, Cai Q, et al. Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. Ann Rheum Dis. 2014;73(11):1962-7.
Jin, Z., Xiang, C., Cai, Q., Wei, X., & He, J. (2014). Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. Annals of the Rheumatic Diseases, 73(11), 1962-7. https://doi.org/10.1136/annrheumdis-2013-203323
Jin Z, et al. Alcohol Consumption as a Preventive Factor for Developing Rheumatoid Arthritis: a Dose-response Meta-analysis of Prospective Studies. Ann Rheum Dis. 2014;73(11):1962-7. PubMed PMID: 23897767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. AU - Jin,Zhichao, AU - Xiang,Chun, AU - Cai,Qing, AU - Wei,Xin, AU - He,Jia, Y1 - 2013/07/29/ PY - 2013/7/31/entrez PY - 2013/7/31/pubmed PY - 2014/12/15/medline KW - Epidemiology KW - Inflammation KW - Rheumatoid Arthritis SP - 1962 EP - 7 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 73 IS - 11 N2 - OBJECTIVE: To summarise the evidence regarding the dose-response association between alcohol consumption and risk of rheumatoid arthritis (RA). METHOD: Studies were identified from search of MEDLINE, Embase and Web of Science databases between 1 January 1946 and 10 April 2013, and from review of the conference abstracts and the reference lists of retrieved articles. Prospective studies that reported relative risks (RRs) with 95% CIs for the association between alcohol consumption and the risk of RA were included. Results from individual studies were pooled using a dose-response meta-analysis. RESULTS: Up to 10 April 2013, 8 prospective studies contained 195 029 participants and 1878 RA cases were included. The results indicated that low to moderate alcohol consumption yielded a preventive effect on RA development (RR: 0.86; 95% CI 0.78 to 0.94), and provided some evidence of a non-linear relationship between alcohol consumption and risk of RA. Dose-response meta-analysis of the study data revealed that compared with that for no alcohol consumption, the adjusted RR was 0.93 (95% CI 0.88 to 0.98) for 3 g/day of alcohol consumption, 0.86 (95% CI 0.76 to 0.97) for 9 g/day, 0.88 (95% CI 0.78 to 0.99) for 12 g/day, 0.91 (95% CI 0.81 to 1.03) for 15 g/day, and 1.28 (95% CI 0.94 to 1.73) for 30 g/day. Subgroup analysis indicated that women who had low to moderate alcohol consumption had a 19% reduction in RA risk. Regardless of sex, a consistent low to moderate alcohol consumption for a period of at least 10 years was found to have a 17% reduction in RA risk. CONCLUSIONS: Low to moderate alcohol consumption inversely associated with the development of RA in a manner that appears to be dose-dependent, time-dependent and sex-dependent. Large prospective studies that investigate gene-environment interactions are required to further clarify the aetiology of RA. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/23897767/Alcohol_consumption_as_a_preventive_factor_for_developing_rheumatoid_arthritis:_a_dose_response_meta_analysis_of_prospective_studies_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&pmid=23897767 DB - PRIME DP - Unbound Medicine ER -