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Psychotropic drugs as potential antitumor agents: a selective screening study.
Cancer Treat Rep. 1978 Jan; 62(1):45-74.CT

Abstract

Compounds with known psychotropic properties were tested for activity in murine ip L1210 leukemia and B 16 melanoma in a protocol designed to obtain leads for new antitumor agents which might also possess central nervous system (CNS) antitumor properties. Barbiturates and hallucinogenic compounds were the only compound types deliberately excluded. Representatives from most of the other known CNS agent classes were included among the 297 psychotropic drugs evaluated. Sixteen of these agents were reproducibly active against the L1210 tumor system with T/C values of 125%. Phenothiazines such as fluphenazine and butyrophenones such as triperidol were prominent among the confirmed active structural types. Dopamine, a beta-phenethylamine neurotrasmitter, was active. While reproducible B16 melanoma activity was not observed among the psychotropic drugs, most of the L1210 confirmed active agents were effective against the ip P388 tumor model and also were active in vitro against KB cells. Ic L1210 activity was not observed among the few compounds chosen for testing in that tumor system. The yield of ip L1210 confirmed actives from this group of psychotropic agents was 18 times that which would have been expected from the random screening of compounds.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

23898

Citation

Driscoll, J S., et al. "Psychotropic Drugs as Potential Antitumor Agents: a Selective Screening Study." Cancer Treatment Reports, vol. 62, no. 1, 1978, pp. 45-74.
Driscoll JS, Melnick NR, Quinn FR, et al. Psychotropic drugs as potential antitumor agents: a selective screening study. Cancer Treat Rep. 1978;62(1):45-74.
Driscoll, J. S., Melnick, N. R., Quinn, F. R., Lomax, N., Davignon, J. P., Ing, R., Abott, B. J., Congleton, G., & Dudeck, L. (1978). Psychotropic drugs as potential antitumor agents: a selective screening study. Cancer Treatment Reports, 62(1), 45-74.
Driscoll JS, et al. Psychotropic Drugs as Potential Antitumor Agents: a Selective Screening Study. Cancer Treat Rep. 1978;62(1):45-74. PubMed PMID: 23898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychotropic drugs as potential antitumor agents: a selective screening study. AU - Driscoll,J S, AU - Melnick,N R, AU - Quinn,F R, AU - Lomax,N, AU - Davignon,J P, AU - Ing,R, AU - Abott,B J, AU - Congleton,G, AU - Dudeck,L, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 45 EP - 74 JF - Cancer treatment reports JO - Cancer Treat Rep VL - 62 IS - 1 N2 - Compounds with known psychotropic properties were tested for activity in murine ip L1210 leukemia and B 16 melanoma in a protocol designed to obtain leads for new antitumor agents which might also possess central nervous system (CNS) antitumor properties. Barbiturates and hallucinogenic compounds were the only compound types deliberately excluded. Representatives from most of the other known CNS agent classes were included among the 297 psychotropic drugs evaluated. Sixteen of these agents were reproducibly active against the L1210 tumor system with T/C values of 125%. Phenothiazines such as fluphenazine and butyrophenones such as triperidol were prominent among the confirmed active structural types. Dopamine, a beta-phenethylamine neurotrasmitter, was active. While reproducible B16 melanoma activity was not observed among the psychotropic drugs, most of the L1210 confirmed active agents were effective against the ip P388 tumor model and also were active in vitro against KB cells. Ic L1210 activity was not observed among the few compounds chosen for testing in that tumor system. The yield of ip L1210 confirmed actives from this group of psychotropic agents was 18 times that which would have been expected from the random screening of compounds. SN - 0361-5960 UR - https://www.unboundmedicine.com/medline/citation/23898/Psychotropic_drugs_as_potential_antitumor_agents:_a_selective_screening_study_ L2 - https://medlineplus.gov/melanoma.html DB - PRIME DP - Unbound Medicine ER -