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Effects of estrogen therapy and aerobic training on sympathetic activity and hemodynamics in healthy postmenopausal women: a double-blind randomized trial.
Menopause. 2014 Apr; 21(4):369-75.M

Abstract

OBJECTIVE

The aim of this study was to evaluate the isolated and associated effects of aerobic training and estrogen therapy on sympathetic nerve activity and hemodynamics in healthy postmenopausal women.

METHODS

Forty-five postmenopausal women (mean [SD] age, 51 [3] y) were randomly divided into four groups: sedentary-placebo (SED-PLA; n = 11), sedentary-estrogen therapy (SED-ET; n = 14), aerobic training-placebo (AT-PLA; n = 12), and aerobic training-estrogen therapy (AT-ET; n = 8). The ET groups received oral estradiol valerate (1 mg/d), whereas the PLA groups received placebo. The AT groups performed aerobic exercise three times a week on a cycle ergometer for 50 minutes, whereas the SED groups remained sedentary. All participants were evaluated before and after 6 months. Muscle sympathetic nerve activity (MSNA; microneurography), forearm blood flow (plethysmography), blood pressure (oscillometry), and heart rate (HR) were measured at rest for 10 minutes. Data were analyzed by three-way analysis of variance.

RESULTS

Estrogen administration itself did not change any of the studied parameters. AT improved forearm blood flow (AT-PLA, 2.02 [0.85] vs 2.92 [1.65] mL min(-1) 100 mL(-1), P = 0.03; AT-ET, 1.68 [1.11] vs 2.27 [0.76] mL min(-1) 100 mL(-1), P = 0.03), reduced MSNA in the AT-PLA group (39 [6] vs 34 [5] bursts/min(-1), P = 0.01), and decreased HR in the AT-ET group (65 [8] vs 62 [7] beats/min, P = 0.01).

CONCLUSIONS

AT reduces sympathetic nerve activity and improves muscle blood flow in healthy hysterectomized postmenopausal women. Moreover, AT decreases HR when combined with ET. However, ET abolishes the reducing effect of AT on MSNA.

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Authors+Show Affiliations

Oneda B
From the 1Hypertension Unit, General Hospital, and 2Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil; 3Center for Sport and Physical Education, State University of Londrina, Londrina, Brazil; and 4Gynecology and Climacteric Service, General Hospital, University of São Paulo, São Paulo, Brazil.
Cardoso CG
No affiliation info available
Forjaz CL
No affiliation info available
Araújo TG
No affiliation info available
Bernardo FR
No affiliation info available
de Gusmão JL
No affiliation info available
Pinto LG
No affiliation info available
Labes E
No affiliation info available
Abrahão SB
No affiliation info available
Mion D
No affiliation info available
Fonseca AM
No affiliation info available
Tinucci T
No affiliation info available

MeSH

Blood PressureDouble-Blind MethodEstradiolEstrogen Replacement TherapyExerciseExercise TestFemaleHeart RateHemodynamicsHumansHysterectomyMiddle AgedOxygen ConsumptionPilot ProjectsPlacebosPostmenopauseSympathetic Nervous System

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23899829

Citation

Oneda, Bruna, et al. "Effects of Estrogen Therapy and Aerobic Training On Sympathetic Activity and Hemodynamics in Healthy Postmenopausal Women: a Double-blind Randomized Trial." Menopause (New York, N.Y.), vol. 21, no. 4, 2014, pp. 369-75.
Oneda B, Cardoso CG, Forjaz CL, et al. Effects of estrogen therapy and aerobic training on sympathetic activity and hemodynamics in healthy postmenopausal women: a double-blind randomized trial. Menopause. 2014;21(4):369-75.
Oneda, B., Cardoso, C. G., Forjaz, C. L., Araújo, T. G., Bernardo, F. R., de Gusmão, J. L., Pinto, L. G., Labes, E., Abrahão, S. B., Mion, D., Fonseca, A. M., & Tinucci, T. (2014). Effects of estrogen therapy and aerobic training on sympathetic activity and hemodynamics in healthy postmenopausal women: a double-blind randomized trial. Menopause (New York, N.Y.), 21(4), 369-75. https://doi.org/10.1097/GME.0b013e31829d2a00
Oneda B, et al. Effects of Estrogen Therapy and Aerobic Training On Sympathetic Activity and Hemodynamics in Healthy Postmenopausal Women: a Double-blind Randomized Trial. Menopause. 2014;21(4):369-75. PubMed PMID: 23899829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of estrogen therapy and aerobic training on sympathetic activity and hemodynamics in healthy postmenopausal women: a double-blind randomized trial. AU - Oneda,Bruna, AU - Cardoso,Crivaldo G,Jr AU - Forjaz,Cláudia L M, AU - Araújo,Tatiana G, AU - Bernardo,Fernanda R, AU - de Gusmão,Josiane Lima, AU - Pinto,Luiz Gustavo, AU - Labes,Eliana, AU - Abrahão,Sandra B, AU - Mion,Décio,Jr AU - Fonseca,Angela M, AU - Tinucci,Taís, PY - 2013/8/1/entrez PY - 2013/8/1/pubmed PY - 2014/12/15/medline SP - 369 EP - 75 JF - Menopause (New York, N.Y.) JO - Menopause VL - 21 IS - 4 N2 - OBJECTIVE: The aim of this study was to evaluate the isolated and associated effects of aerobic training and estrogen therapy on sympathetic nerve activity and hemodynamics in healthy postmenopausal women. METHODS: Forty-five postmenopausal women (mean [SD] age, 51 [3] y) were randomly divided into four groups: sedentary-placebo (SED-PLA; n = 11), sedentary-estrogen therapy (SED-ET; n = 14), aerobic training-placebo (AT-PLA; n = 12), and aerobic training-estrogen therapy (AT-ET; n = 8). The ET groups received oral estradiol valerate (1 mg/d), whereas the PLA groups received placebo. The AT groups performed aerobic exercise three times a week on a cycle ergometer for 50 minutes, whereas the SED groups remained sedentary. All participants were evaluated before and after 6 months. Muscle sympathetic nerve activity (MSNA; microneurography), forearm blood flow (plethysmography), blood pressure (oscillometry), and heart rate (HR) were measured at rest for 10 minutes. Data were analyzed by three-way analysis of variance. RESULTS: Estrogen administration itself did not change any of the studied parameters. AT improved forearm blood flow (AT-PLA, 2.02 [0.85] vs 2.92 [1.65] mL min(-1) 100 mL(-1), P = 0.03; AT-ET, 1.68 [1.11] vs 2.27 [0.76] mL min(-1) 100 mL(-1), P = 0.03), reduced MSNA in the AT-PLA group (39 [6] vs 34 [5] bursts/min(-1), P = 0.01), and decreased HR in the AT-ET group (65 [8] vs 62 [7] beats/min, P = 0.01). CONCLUSIONS: AT reduces sympathetic nerve activity and improves muscle blood flow in healthy hysterectomized postmenopausal women. Moreover, AT decreases HR when combined with ET. However, ET abolishes the reducing effect of AT on MSNA. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/23899829/Effects_of_estrogen_therapy_and_aerobic_training_on_sympathetic_activity_and_hemodynamics_in_healthy_postmenopausal_women:_a_double_blind_randomized_trial_ L2 - https://doi.org/10.1097/GME.0b013e31829d2a00 DB - PRIME DP - Unbound Medicine ER -