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Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats.
Environ Toxicol. 2015 Jan; 30(1):26-43.ET

Abstract

Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-CYP on lung tissues. For this purpose, thirty two male rats were divided into four different groups (eight rats for each). Group (I) gavaged with corn oil (control group), group (II) gavaged daily with NAC (150 mg kg(-1) body weight), group (III) gavaged with α-CYP (14.5 mg kg(-1) body weight/day, dissolved in corn oil), group (IV) gavaged with NAC then with α-CYP 2 h later for 12 weeks. α-CYP significantly increased serum lactate dehydrogenase (LDH) and pulmonary malondialdehyde (MDA) levels, while decreased the activities of catalase (CAT) and superoxide dismutase (SOD) as well as reduced glutathione (GSH) content in lung. It also provoked higher levels of serum nitric oxide (NO), lung interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), hydroxyproline (Hyp) as well as heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-К B) gene expression in lung tissues. Histopathological alterations in lung with congestion, cellular infiltration, necrotic changes and thickening of inter-alveolar septa were observed following α-CYP administration. NAC reduced the adverse effects of α-CYP on lung tissues and improved the histological architecture of lung since it showed antioxidant, anti-inflammatory and antifibrotic effects on lung tissues. Our results indicate that NAC exerts a potent protective effect against α-CYP-induced oxidative damage and inflammation in lung tissues.

Authors+Show Affiliations

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia Government, Egypt.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23900960

Citation

Arafa, Manar Hamed, et al. "Ameliorative Effect of N-acetyl Cysteine On Alpha-cypermethrin-induced Pulmonary Toxicity in Male Rats." Environmental Toxicology, vol. 30, no. 1, 2015, pp. 26-43.
Arafa MH, Mohamed DA, Atteia HH. Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats. Environ Toxicol. 2015;30(1):26-43.
Arafa, M. H., Mohamed, D. A., & Atteia, H. H. (2015). Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats. Environmental Toxicology, 30(1), 26-43. https://doi.org/10.1002/tox.21891
Arafa MH, Mohamed DA, Atteia HH. Ameliorative Effect of N-acetyl Cysteine On Alpha-cypermethrin-induced Pulmonary Toxicity in Male Rats. Environ Toxicol. 2015;30(1):26-43. PubMed PMID: 23900960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats. AU - Arafa,Manar Hamed, AU - Mohamed,Dalia AbdElmoain, AU - Atteia,Hebatallah Husseini, Y1 - 2013/07/31/ PY - 2013/02/18/received PY - 2013/06/22/revised PY - 2013/06/26/accepted PY - 2013/8/1/entrez PY - 2013/8/1/pubmed PY - 2015/5/15/medline KW - N-acetyl cysteine KW - alpha-cypermethrin KW - antioxidants KW - fibrosis KW - inflammation KW - lung KW - oxidative stress SP - 26 EP - 43 JF - Environmental toxicology JO - Environ Toxicol VL - 30 IS - 1 N2 - Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-CYP on lung tissues. For this purpose, thirty two male rats were divided into four different groups (eight rats for each). Group (I) gavaged with corn oil (control group), group (II) gavaged daily with NAC (150 mg kg(-1) body weight), group (III) gavaged with α-CYP (14.5 mg kg(-1) body weight/day, dissolved in corn oil), group (IV) gavaged with NAC then with α-CYP 2 h later for 12 weeks. α-CYP significantly increased serum lactate dehydrogenase (LDH) and pulmonary malondialdehyde (MDA) levels, while decreased the activities of catalase (CAT) and superoxide dismutase (SOD) as well as reduced glutathione (GSH) content in lung. It also provoked higher levels of serum nitric oxide (NO), lung interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), hydroxyproline (Hyp) as well as heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-К B) gene expression in lung tissues. Histopathological alterations in lung with congestion, cellular infiltration, necrotic changes and thickening of inter-alveolar septa were observed following α-CYP administration. NAC reduced the adverse effects of α-CYP on lung tissues and improved the histological architecture of lung since it showed antioxidant, anti-inflammatory and antifibrotic effects on lung tissues. Our results indicate that NAC exerts a potent protective effect against α-CYP-induced oxidative damage and inflammation in lung tissues. SN - 1522-7278 UR - https://www.unboundmedicine.com/medline/citation/23900960/Ameliorative_effect_of_N_acetyl_cysteine_on_alpha_cypermethrin_induced_pulmonary_toxicity_in_male_rats_ L2 - https://doi.org/10.1002/tox.21891 DB - PRIME DP - Unbound Medicine ER -