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Biology, systematics, life cycle, and distribution of Angiostrongylus cantonensis, the cause of rat lungworm disease.
Hawaii J Med Public Health. 2013 Jun; 72(6 Suppl 2):6-9.HJ

Abstract

Angiostrongylus cantonensis is a metastrongyloid nematode in the family Angiostrongylidae. It is the cause of angiostrongyliasis (rat lungworm disease), which manifests as eosinophilic meningitis. First described in 1935 from rats in China, A. cantonensis was placed in the genus Parastrongylus in 1986, but most workers have not adopted this treatment. The taxonomy of A. cantonensis and related worms is largely based on adult morphology, notably of the male bursa. However, identification of infective third stage larvae is more difficult. The natural life cycle involves rats as the definitive host and snails or slugs as the intermediate host. Human infection, as accidental hosts, results in worms maturing in the brain, but dying there instead of moving back into the bloodstream, as in rats, thereby leading to eosinophilic meningitis. The disease is an emerging infectious disease; Angiostrongylus cantonensis continues to be reported in new regions beyond its native range.

Authors+Show Affiliations

Pacific Biosciences Research Center, University of Hawa'i, Honolulu, HI 96822 , USA. cowie@hawaii.edu

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23901372

Citation

Cowie, Robert H.. "Biology, Systematics, Life Cycle, and Distribution of Angiostrongylus Cantonensis, the Cause of Rat Lungworm Disease." Hawai'i Journal of Medicine & Public Health : a Journal of Asia Pacific Medicine & Public Health, vol. 72, no. 6 Suppl 2, 2013, pp. 6-9.
Cowie RH. Biology, systematics, life cycle, and distribution of Angiostrongylus cantonensis, the cause of rat lungworm disease. Hawaii J Med Public Health. 2013;72(6 Suppl 2):6-9.
Cowie, R. H. (2013). Biology, systematics, life cycle, and distribution of Angiostrongylus cantonensis, the cause of rat lungworm disease. Hawai'i Journal of Medicine & Public Health : a Journal of Asia Pacific Medicine & Public Health, 72(6 Suppl 2), 6-9.
Cowie RH. Biology, Systematics, Life Cycle, and Distribution of Angiostrongylus Cantonensis, the Cause of Rat Lungworm Disease. Hawaii J Med Public Health. 2013;72(6 Suppl 2):6-9. PubMed PMID: 23901372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biology, systematics, life cycle, and distribution of Angiostrongylus cantonensis, the cause of rat lungworm disease. A1 - Cowie,Robert H, PY - 2013/8/1/entrez PY - 2013/8/2/pubmed PY - 2014/5/23/medline KW - Angiostrongyliasis KW - Angiostrongylus cantonensis KW - Emerging infectious disease KW - Eosinophilic meningitis KW - Parasitology KW - Rat lungworm disease KW - Slugs KW - Snails SP - 6 EP - 9 JF - Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health JO - Hawaii J Med Public Health VL - 72 IS - 6 Suppl 2 N2 - Angiostrongylus cantonensis is a metastrongyloid nematode in the family Angiostrongylidae. It is the cause of angiostrongyliasis (rat lungworm disease), which manifests as eosinophilic meningitis. First described in 1935 from rats in China, A. cantonensis was placed in the genus Parastrongylus in 1986, but most workers have not adopted this treatment. The taxonomy of A. cantonensis and related worms is largely based on adult morphology, notably of the male bursa. However, identification of infective third stage larvae is more difficult. The natural life cycle involves rats as the definitive host and snails or slugs as the intermediate host. Human infection, as accidental hosts, results in worms maturing in the brain, but dying there instead of moving back into the bloodstream, as in rats, thereby leading to eosinophilic meningitis. The disease is an emerging infectious disease; Angiostrongylus cantonensis continues to be reported in new regions beyond its native range. SN - 2165-8242 UR - https://www.unboundmedicine.com/medline/citation/23901372/Biology_systematics_life_cycle_and_distribution_of_Angiostrongylus_cantonensis_the_cause_of_rat_lungworm_disease_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23901372/ DB - PRIME DP - Unbound Medicine ER -