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Role of LC-MS/MS in hair testing for the determination of common drugs of abuse and other psychoactive drugs.
Bioanalysis. 2013 Aug; 5(15):1919-38.B

Abstract

Hair testing has been used in toxicological investigations for the last two decades, but only recently a remarkable extension of hair analysis to a variety of application fields was observed, besides drug abuse recognition. The dramatic improvements of LC-MS/MS instrumentation make the detection of tiny amounts of almost whatever drug in hair possible, even after single-dose intake. The progresses observed during the last 5 years in the detection of psychoactive substances in hair are reviewed herein. The literature is partitioned according to the target compounds, namely traditional drugs of abuse, new psychoactive substances and pharmaceutical psychoactive substances. The LC-MS/MS methods presented are addressed to determine a single class of drugs, with the primary aim of accurate quantitation, or to perform multiclass analysis, for rapid and effective screening protocols.

Authors+Show Affiliations

Centro Regionale Antidoping e di Tossicologia 'A. Bertinaria', Regione Gonzole 10/1, 10043 Orbassano, Torino, Italy. marco.vincenti@unito.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23905865

Citation

Vincenti, Marco, et al. "Role of LC-MS/MS in Hair Testing for the Determination of Common Drugs of Abuse and Other Psychoactive Drugs." Bioanalysis, vol. 5, no. 15, 2013, pp. 1919-38.
Vincenti M, Salomone A, Gerace E, et al. Role of LC-MS/MS in hair testing for the determination of common drugs of abuse and other psychoactive drugs. Bioanalysis. 2013;5(15):1919-38.
Vincenti, M., Salomone, A., Gerace, E., & Pirro, V. (2013). Role of LC-MS/MS in hair testing for the determination of common drugs of abuse and other psychoactive drugs. Bioanalysis, 5(15), 1919-38. https://doi.org/10.4155/bio.13.132
Vincenti M, et al. Role of LC-MS/MS in Hair Testing for the Determination of Common Drugs of Abuse and Other Psychoactive Drugs. Bioanalysis. 2013;5(15):1919-38. PubMed PMID: 23905865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of LC-MS/MS in hair testing for the determination of common drugs of abuse and other psychoactive drugs. AU - Vincenti,Marco, AU - Salomone,Alberto, AU - Gerace,Enrico, AU - Pirro,Valentina, PY - 2013/8/3/entrez PY - 2013/8/3/pubmed PY - 2013/11/12/medline SP - 1919 EP - 38 JF - Bioanalysis JO - Bioanalysis VL - 5 IS - 15 N2 - Hair testing has been used in toxicological investigations for the last two decades, but only recently a remarkable extension of hair analysis to a variety of application fields was observed, besides drug abuse recognition. The dramatic improvements of LC-MS/MS instrumentation make the detection of tiny amounts of almost whatever drug in hair possible, even after single-dose intake. The progresses observed during the last 5 years in the detection of psychoactive substances in hair are reviewed herein. The literature is partitioned according to the target compounds, namely traditional drugs of abuse, new psychoactive substances and pharmaceutical psychoactive substances. The LC-MS/MS methods presented are addressed to determine a single class of drugs, with the primary aim of accurate quantitation, or to perform multiclass analysis, for rapid and effective screening protocols. SN - 1757-6199 UR - https://www.unboundmedicine.com/medline/citation/23905865/Role_of_LC_MS/MS_in_hair_testing_for_the_determination_of_common_drugs_of_abuse_and_other_psychoactive_drugs_ L2 - https://www.future-science.com/doi/10.4155/bio.13.132?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -