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Changes in calcitonin gene-related peptide (CGRP)-containing vasodilator nerve activity in hypertension.
Brain Res. 1990 Jun 04; 518(1-2):303-7.BR

Abstract

The role of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves in maintenance of hypertension was investigated in the perfused mesenteric vascular beds isolated from spontaneously hypertensive rats (SHR), deoxycorticosterone-salt-induced hypertensive rats (DOCA-Salt-HR) and corresponding normotensive control rats (Wistar Kyoto rats, WKY and Wistar rats, NR). In the mesenteric artery with an active tone, the neurogenic vasodilation induced by perivascular nerve stimulation (PNS, 0.5-8 Hz), which was mediated by CGRP nerves, was markedly decreased in adult SHR (15-week-old) when compared with age-matched WKY, whereas the vasodilation in DOCA-Salt-HR was similar in magnitude to that in NR. The vasodilator response to exogenously applied CGRP was greater in SHR than in WKY, whereas no difference was found between DOCA-Salt-HR and NR. The neurogenic release of CGRP-like immunoreactivity (CGRP-LI) induced by PNS of the mesenteric artery was significantly decreased in SHR compared to that of WKY. In addition, immunohistochemical studies showed decreased populations of CGRP-LI fibers in the mesenteric artery of SHR compared to those in WKY. These results suggest that CGRP-containing vasodilator innervation is greatly decreased in SHR with established hypertension. It is also suggested that the decreased vasodilator mechanism by CGRP-containing nerves contributes to the maintenance of hypertension.

Authors+Show Affiliations

Department of Pharmacology, Miyazaki Medical College, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2390722

Citation

Kawasaki, H, et al. "Changes in Calcitonin Gene-related Peptide (CGRP)-containing Vasodilator Nerve Activity in Hypertension." Brain Research, vol. 518, no. 1-2, 1990, pp. 303-7.
Kawasaki H, Saito A, Takasaki K. Changes in calcitonin gene-related peptide (CGRP)-containing vasodilator nerve activity in hypertension. Brain Res. 1990;518(1-2):303-7.
Kawasaki, H., Saito, A., & Takasaki, K. (1990). Changes in calcitonin gene-related peptide (CGRP)-containing vasodilator nerve activity in hypertension. Brain Research, 518(1-2), 303-7.
Kawasaki H, Saito A, Takasaki K. Changes in Calcitonin Gene-related Peptide (CGRP)-containing Vasodilator Nerve Activity in Hypertension. Brain Res. 1990 Jun 4;518(1-2):303-7. PubMed PMID: 2390722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in calcitonin gene-related peptide (CGRP)-containing vasodilator nerve activity in hypertension. AU - Kawasaki,H, AU - Saito,A, AU - Takasaki,K, PY - 1990/6/4/pubmed PY - 1990/6/4/medline PY - 1990/6/4/entrez SP - 303 EP - 7 JF - Brain research JO - Brain Res VL - 518 IS - 1-2 N2 - The role of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves in maintenance of hypertension was investigated in the perfused mesenteric vascular beds isolated from spontaneously hypertensive rats (SHR), deoxycorticosterone-salt-induced hypertensive rats (DOCA-Salt-HR) and corresponding normotensive control rats (Wistar Kyoto rats, WKY and Wistar rats, NR). In the mesenteric artery with an active tone, the neurogenic vasodilation induced by perivascular nerve stimulation (PNS, 0.5-8 Hz), which was mediated by CGRP nerves, was markedly decreased in adult SHR (15-week-old) when compared with age-matched WKY, whereas the vasodilation in DOCA-Salt-HR was similar in magnitude to that in NR. The vasodilator response to exogenously applied CGRP was greater in SHR than in WKY, whereas no difference was found between DOCA-Salt-HR and NR. The neurogenic release of CGRP-like immunoreactivity (CGRP-LI) induced by PNS of the mesenteric artery was significantly decreased in SHR compared to that of WKY. In addition, immunohistochemical studies showed decreased populations of CGRP-LI fibers in the mesenteric artery of SHR compared to those in WKY. These results suggest that CGRP-containing vasodilator innervation is greatly decreased in SHR with established hypertension. It is also suggested that the decreased vasodilator mechanism by CGRP-containing nerves contributes to the maintenance of hypertension. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/2390722/Changes_in_calcitonin_gene_related_peptide__CGRP__containing_vasodilator_nerve_activity_in_hypertension_ DB - PRIME DP - Unbound Medicine ER -