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Bath salts and synthetic cathinones: an emerging designer drug phenomenon.
Life Sci. 2014 Feb 27; 97(1):2-8.LS

Abstract

Synthetic cathinones are an emerging class of designer drugs abused for psychostimulant and hallucinogenic effects similar to cocaine, methylenedioxymethamphetamine (MDMA), or other amphetamines. Abuse of synthetic cathinones, frequently included in products sold as 'bath salts', became prevalent in early 2009, leading to legislative classification throughout Europe in 2010 and schedule I classification within the United States in 2011. Recent pre-clinical and clinical studies indicate that dysregulation of central monoamine systems is a principal mechanism of synthetic cathinone action and presumably underlie the behavioral effects and abuse liability associated with these drugs. This review provides insight into the development of synthetic cathinones as substances of abuse, current patterns of their abuse, known mechanisms of their action and toxicology, and the benefits and drawbacks of their classification.

Authors+Show Affiliations

Department of Pharmacology & Toxicology, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: christopher.german@utah.edu.Department of Pharmacology & Toxicology, University of Utah, Salt Lake City, UT 84112, USA.Department of Pharmacology & Toxicology, University of Utah, Salt Lake City, UT 84112, USA.

Pub Type(s)

Historical Article
Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

23911668

Citation

German, Christopher L., et al. "Bath Salts and Synthetic Cathinones: an Emerging Designer Drug Phenomenon." Life Sciences, vol. 97, no. 1, 2014, pp. 2-8.
German CL, Fleckenstein AE, Hanson GR. Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Sci. 2014;97(1):2-8.
German, C. L., Fleckenstein, A. E., & Hanson, G. R. (2014). Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Sciences, 97(1), 2-8. https://doi.org/10.1016/j.lfs.2013.07.023
German CL, Fleckenstein AE, Hanson GR. Bath Salts and Synthetic Cathinones: an Emerging Designer Drug Phenomenon. Life Sci. 2014 Feb 27;97(1):2-8. PubMed PMID: 23911668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bath salts and synthetic cathinones: an emerging designer drug phenomenon. AU - German,Christopher L, AU - Fleckenstein,Annette E, AU - Hanson,Glen R, Y1 - 2013/08/02/ PY - 2013/05/03/received PY - 2013/07/17/revised PY - 2013/07/19/accepted PY - 2013/8/6/entrez PY - 2013/8/6/pubmed PY - 2014/4/16/medline KW - Bath salts KW - Designer drugs KW - MDPV KW - Mephedrone KW - Methylone KW - Stimulants KW - Synthetic cathinone SP - 2 EP - 8 JF - Life sciences JO - Life Sci. VL - 97 IS - 1 N2 - Synthetic cathinones are an emerging class of designer drugs abused for psychostimulant and hallucinogenic effects similar to cocaine, methylenedioxymethamphetamine (MDMA), or other amphetamines. Abuse of synthetic cathinones, frequently included in products sold as 'bath salts', became prevalent in early 2009, leading to legislative classification throughout Europe in 2010 and schedule I classification within the United States in 2011. Recent pre-clinical and clinical studies indicate that dysregulation of central monoamine systems is a principal mechanism of synthetic cathinone action and presumably underlie the behavioral effects and abuse liability associated with these drugs. This review provides insight into the development of synthetic cathinones as substances of abuse, current patterns of their abuse, known mechanisms of their action and toxicology, and the benefits and drawbacks of their classification. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/23911668/Bath_salts_and_synthetic_cathinones:_an_emerging_designer_drug_phenomenon_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(13)00424-4 DB - PRIME DP - Unbound Medicine ER -