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Novel bioadhesive hyaluronan-itaconic acid crosslinked films for ocular therapy.
Int J Pharm 2013; 455(1-2):48-56IJ

Abstract

New hyaluronic acid (HA)-itaconic acid (IT) films have been previously synthesized and used as potential topical drug delivery systems (DDS) for ocular administration. In this study we explored homogeneous and heterogeneous crosslinking reactions of HA using glutaraldehyde (GTA) and polyethylene glycol diglycidyl ether (PEGDE) in the presence of IT, a naturally occurring compound that is non-toxic and readily biodegradable. We have studied the morphology, mechanical properties and in vitro biocompatibility between these new materials and ocular surface cells (human corneal epithelial cell line) and evaluated the biopharmaceutical performance of the designed formulations. Although all the synthesized materials exhibited good mechanical properties, the PEGDE modified films exhibited the best biocompatibility, with in vivo assays showing good adhesive performance and minimal irritation. PEGDE films were also tested for their effects in the treatment of intraocular pressure (IOP) in rabbits using timolol maleate (TM) as the model drug. These results may be useful for further design of novel bioadhesive matrix containing drugs by topical application in ophthalmology.

Authors+Show Affiliations

PLAPIQUI-CONICET, Universidad Nacional del Sur (UNS), Camino La Carrindanga km 7, Bahía Blanca, 8000, Argentina. javieradcalles@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23911915

Citation

Calles, J A., et al. "Novel Bioadhesive Hyaluronan-itaconic Acid Crosslinked Films for Ocular Therapy." International Journal of Pharmaceutics, vol. 455, no. 1-2, 2013, pp. 48-56.
Calles JA, Tártara LI, Lopez-García A, et al. Novel bioadhesive hyaluronan-itaconic acid crosslinked films for ocular therapy. Int J Pharm. 2013;455(1-2):48-56.
Calles, J. A., Tártara, L. I., Lopez-García, A., Diebold, Y., Palma, S. D., & Vallés, E. M. (2013). Novel bioadhesive hyaluronan-itaconic acid crosslinked films for ocular therapy. International Journal of Pharmaceutics, 455(1-2), pp. 48-56. doi:10.1016/j.ijpharm.2013.07.063.
Calles JA, et al. Novel Bioadhesive Hyaluronan-itaconic Acid Crosslinked Films for Ocular Therapy. Int J Pharm. 2013 Oct 15;455(1-2):48-56. PubMed PMID: 23911915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel bioadhesive hyaluronan-itaconic acid crosslinked films for ocular therapy. AU - Calles,J A, AU - Tártara,L I, AU - Lopez-García,A, AU - Diebold,Y, AU - Palma,S D, AU - Vallés,E M, Y1 - 2013/08/01/ PY - 2013/03/15/received PY - 2013/06/24/revised PY - 2013/07/19/accepted PY - 2013/8/6/entrez PY - 2013/8/6/pubmed PY - 2014/3/26/medline KW - BKC KW - Bioadhesive KW - DDS KW - Drug delivery KW - ESEM KW - FBS KW - GTA KW - Glaucoma KW - HA KW - HCE KW - Hyaluronan KW - IOP KW - IT KW - PEG KW - PEGDE KW - Polymer KW - RT KW - SR KW - TM KW - benzalkonium chloride KW - delivery systems KW - environmental scanning electron microscopy KW - fetal bovine serum KW - glutaraldehyde KW - human corneal epithelial KW - hyaluronic acid KW - intraocular pressure KW - itaconic acid KW - polyethylene glycol KW - polyethylene glycol diglycidyl ether KW - room temperature KW - swelling ratio KW - timolol maleate SP - 48 EP - 56 JF - International journal of pharmaceutics JO - Int J Pharm VL - 455 IS - 1-2 N2 - New hyaluronic acid (HA)-itaconic acid (IT) films have been previously synthesized and used as potential topical drug delivery systems (DDS) for ocular administration. In this study we explored homogeneous and heterogeneous crosslinking reactions of HA using glutaraldehyde (GTA) and polyethylene glycol diglycidyl ether (PEGDE) in the presence of IT, a naturally occurring compound that is non-toxic and readily biodegradable. We have studied the morphology, mechanical properties and in vitro biocompatibility between these new materials and ocular surface cells (human corneal epithelial cell line) and evaluated the biopharmaceutical performance of the designed formulations. Although all the synthesized materials exhibited good mechanical properties, the PEGDE modified films exhibited the best biocompatibility, with in vivo assays showing good adhesive performance and minimal irritation. PEGDE films were also tested for their effects in the treatment of intraocular pressure (IOP) in rabbits using timolol maleate (TM) as the model drug. These results may be useful for further design of novel bioadhesive matrix containing drugs by topical application in ophthalmology. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/23911915/Novel_bioadhesive_hyaluronan_itaconic_acid_crosslinked_films_for_ocular_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(13)00689-3 DB - PRIME DP - Unbound Medicine ER -