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Bacterial vaginosis: a review on clinical trials with probiotics.
New Microbiol. 2013 Jul; 36(3):229-38.NM

Abstract

Bacterial vaginosis (BV) is the most common vaginal syndrome afflicting fertile, premenopausal and pregnant women. BV is associated with important adverse health conditions and infectious complications. Therapy with oral or local recommended antibiotics is often associated with failure and high rates of recurrences. The dominance of lactobacilli in healthy vaginal microbiota and its depletion in BV has given rise to the concept of oral or vaginal use of probiotic Lactobacillus strains for treatment and prevention of BV. This review investigated the evidence for the use of a single strain or cocktail of probiotics, administered orally or intravaginally, either alone or in conjunction with antibiotics for the treatment of BV. Lactobacilli use in BV is supported by positive results obtained in some clinical trials. The majority of clinical trials yielding positive results have been performed using probiotic preparations containing high doses of lactobacilli suggesting that, beside strain characteristics, the amount of exogenously applied lactobacilli could have a role in the effectiveness of the product. However, substantial heterogeneity in products, trial methodologies and outcome measures do not provide sufficient evidence for or against recommending probiotics for the treatment of BV.

Authors+Show Affiliations

Department of Public Health and Infectious Diseases, Section of Microbiology, Roma, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23912864

Citation

Mastromarino, Paola, et al. "Bacterial Vaginosis: a Review On Clinical Trials With Probiotics." The New Microbiologica, vol. 36, no. 3, 2013, pp. 229-38.
Mastromarino P, Vitali B, Mosca L. Bacterial vaginosis: a review on clinical trials with probiotics. New Microbiol. 2013;36(3):229-38.
Mastromarino, P., Vitali, B., & Mosca, L. (2013). Bacterial vaginosis: a review on clinical trials with probiotics. The New Microbiologica, 36(3), 229-38.
Mastromarino P, Vitali B, Mosca L. Bacterial Vaginosis: a Review On Clinical Trials With Probiotics. New Microbiol. 2013;36(3):229-38. PubMed PMID: 23912864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bacterial vaginosis: a review on clinical trials with probiotics. AU - Mastromarino,Paola, AU - Vitali,Beatrice, AU - Mosca,Luciana, Y1 - 2013/06/30/ PY - 2013/05/12/received PY - 2013/05/28/accepted PY - 2013/8/6/entrez PY - 2013/8/6/pubmed PY - 2014/1/31/medline SP - 229 EP - 38 JF - The new microbiologica JO - New Microbiol VL - 36 IS - 3 N2 - Bacterial vaginosis (BV) is the most common vaginal syndrome afflicting fertile, premenopausal and pregnant women. BV is associated with important adverse health conditions and infectious complications. Therapy with oral or local recommended antibiotics is often associated with failure and high rates of recurrences. The dominance of lactobacilli in healthy vaginal microbiota and its depletion in BV has given rise to the concept of oral or vaginal use of probiotic Lactobacillus strains for treatment and prevention of BV. This review investigated the evidence for the use of a single strain or cocktail of probiotics, administered orally or intravaginally, either alone or in conjunction with antibiotics for the treatment of BV. Lactobacilli use in BV is supported by positive results obtained in some clinical trials. The majority of clinical trials yielding positive results have been performed using probiotic preparations containing high doses of lactobacilli suggesting that, beside strain characteristics, the amount of exogenously applied lactobacilli could have a role in the effectiveness of the product. However, substantial heterogeneity in products, trial methodologies and outcome measures do not provide sufficient evidence for or against recommending probiotics for the treatment of BV. SN - 1121-7138 UR - https://www.unboundmedicine.com/medline/citation/23912864/Bacterial_vaginosis:_a_review_on_clinical_trials_with_probiotics_ L2 - http://www.newmicrobiologica.org/PUB/allegati_pdf/2013/3/229.pdf DB - PRIME DP - Unbound Medicine ER -