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Fruit and vegetable intake and the risk of colorectal cancer: results from the Shanghai Men's Health Study.
Cancer Causes Control 2013; 24(11):1935-45CC

Abstract

PURPOSE

The observed associations of fruit and vegetable consumption with the risk of colorectal cancer have been inconsistent. Therefore, we aimed to evaluate the association of fruit and vegetable consumption with the risk of colorectal cancer among Chinese men.

METHODS

61,274 male participants aged 40-74 years were included. A validated food frequency questionnaire was administered to collect information on usual dietary intake, including 8 fruits and 38 vegetables commonly consumed by residents of Shanghai. Follow-up for diagnoses of colon or rectal cancer was available through 31 December 2010. Dietary intakes were analyzed both as categorical and continuous variables. Multivariable-adjusted hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) were calculated for colorectal, colon, and rectal cancers using Cox proportional hazards models.

RESULTS

After 390,688 person-years of follow-up, 398 cases of colorectal cancer (236 colon and 162 rectal) were observed in the cohort. Fruit consumption was inversely associated with the risk of colorectal cancer (fifth vs. first quintile HR 0.67; 95 % CI 0.48, 0.95; p trend = 0.03), whereas vegetable intake was not significantly associated with risk. The associations for subgroups of fruits and legumes, but not other vegetable categories, were generally inversely associated with the risk of colon and rectal cancers.

CONCLUSIONS

Fruit intake was generally inversely associated with the risk of colorectal cancer, whereas vegetable consumption was largely unrelated to risk among middle-aged and older Chinese men.

Authors+Show Affiliations

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23913012

Citation

Vogtmann, Emily, et al. "Fruit and Vegetable Intake and the Risk of Colorectal Cancer: Results From the Shanghai Men's Health Study." Cancer Causes & Control : CCC, vol. 24, no. 11, 2013, pp. 1935-45.
Vogtmann E, Xiang YB, Li HL, et al. Fruit and vegetable intake and the risk of colorectal cancer: results from the Shanghai Men's Health Study. Cancer Causes Control. 2013;24(11):1935-45.
Vogtmann, E., Xiang, Y. B., Li, H. L., Levitan, E. B., Yang, G., Waterbor, J. W., ... Shu, X. O. (2013). Fruit and vegetable intake and the risk of colorectal cancer: results from the Shanghai Men's Health Study. Cancer Causes & Control : CCC, 24(11), pp. 1935-45. doi:10.1007/s10552-013-0268-z.
Vogtmann E, et al. Fruit and Vegetable Intake and the Risk of Colorectal Cancer: Results From the Shanghai Men's Health Study. Cancer Causes Control. 2013;24(11):1935-45. PubMed PMID: 23913012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable intake and the risk of colorectal cancer: results from the Shanghai Men's Health Study. AU - Vogtmann,Emily, AU - Xiang,Yong-Bing, AU - Li,Hong-Lan, AU - Levitan,Emily B, AU - Yang,Gong, AU - Waterbor,John W, AU - Gao,Jing, AU - Cai,Hui, AU - Xie,Li, AU - Wu,Qi-Jun, AU - Zhang,Bin, AU - Gao,Yu-Tang, AU - Zheng,Wei, AU - Shu,Xiao-Ou, Y1 - 2013/08/04/ PY - 2013/05/14/received PY - 2013/07/26/accepted PY - 2013/8/6/entrez PY - 2013/8/6/pubmed PY - 2014/6/3/medline SP - 1935 EP - 45 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 11 N2 - PURPOSE: The observed associations of fruit and vegetable consumption with the risk of colorectal cancer have been inconsistent. Therefore, we aimed to evaluate the association of fruit and vegetable consumption with the risk of colorectal cancer among Chinese men. METHODS: 61,274 male participants aged 40-74 years were included. A validated food frequency questionnaire was administered to collect information on usual dietary intake, including 8 fruits and 38 vegetables commonly consumed by residents of Shanghai. Follow-up for diagnoses of colon or rectal cancer was available through 31 December 2010. Dietary intakes were analyzed both as categorical and continuous variables. Multivariable-adjusted hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) were calculated for colorectal, colon, and rectal cancers using Cox proportional hazards models. RESULTS: After 390,688 person-years of follow-up, 398 cases of colorectal cancer (236 colon and 162 rectal) were observed in the cohort. Fruit consumption was inversely associated with the risk of colorectal cancer (fifth vs. first quintile HR 0.67; 95 % CI 0.48, 0.95; p trend = 0.03), whereas vegetable intake was not significantly associated with risk. The associations for subgroups of fruits and legumes, but not other vegetable categories, were generally inversely associated with the risk of colon and rectal cancers. CONCLUSIONS: Fruit intake was generally inversely associated with the risk of colorectal cancer, whereas vegetable consumption was largely unrelated to risk among middle-aged and older Chinese men. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23913012/Fruit_and_vegetable_intake_and_the_risk_of_colorectal_cancer:_results_from_the_Shanghai_Men's_Health_Study_ L2 - https://doi.org/10.1007/s10552-013-0268-z DB - PRIME DP - Unbound Medicine ER -