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Hyperglycemia, hyperinsulinemia, insulin resistance, and the risk of BPH/LUTS severity and progression over time in community dwelling black men: the Flint Men's Health Study.
Urology. 2013 Oct; 82(4):881-6.U

Abstract

OBJECTIVE

To examine the associations between fasting serum glucose, insulin concentrations, and insulin resistance and benign prostatic hyperplasia (BPH) in a population-based cohort of African American men.

METHODS

Using the Flint Men's Health Study (FMHS), we examined how fasting serum glucose and insulin concentrations and calculated Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) related to burden and progression of clinical markers of BPH in African American men aged 40-79 years.

RESULTS

Among 369 men at baseline, mean age was 56.6 years and approximately 70% were overweight/obese (body mass index [BMI] ≥25 kg/m(2)). One hundred forty-eight men (34.4%) reported moderate to severe lower urinary tract symptoms (LUTS) (American Urological Association Symptom Index [AUASI] ≥8). There were no significant trends of metabolic disturbances as measured by serum glucose, insulin, or HOMA-IR in men with indications of BPH compared to those without.

CONCLUSION

In this population-based study of African American men aged 40-79 years, we did not observe any significant associations between hyperglycemia, hyperinsulinemia, and insulin resistance and burden and progression of BPH after adjustment for age and BMI. This may be due, in part, to the single measurement of glucose and insulin, which may not adequately reflect average glucose metabolism. Further studies examining measures of long-term glycemic control and BPH in racially diverse populations are warranted.

Authors+Show Affiliations

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23915515

Citation

Wallner, Lauren P., et al. "Hyperglycemia, Hyperinsulinemia, Insulin Resistance, and the Risk of BPH/LUTS Severity and Progression Over Time in Community Dwelling Black Men: the Flint Men's Health Study." Urology, vol. 82, no. 4, 2013, pp. 881-6.
Wallner LP, Hollingsworth JM, Dunn RL, et al. Hyperglycemia, hyperinsulinemia, insulin resistance, and the risk of BPH/LUTS severity and progression over time in community dwelling black men: the Flint Men's Health Study. Urology. 2013;82(4):881-6.
Wallner, L. P., Hollingsworth, J. M., Dunn, R. L., Kim, C., Herman, W. H., & Sarma, A. V. (2013). Hyperglycemia, hyperinsulinemia, insulin resistance, and the risk of BPH/LUTS severity and progression over time in community dwelling black men: the Flint Men's Health Study. Urology, 82(4), 881-6. https://doi.org/10.1016/j.urology.2013.05.034
Wallner LP, et al. Hyperglycemia, Hyperinsulinemia, Insulin Resistance, and the Risk of BPH/LUTS Severity and Progression Over Time in Community Dwelling Black Men: the Flint Men's Health Study. Urology. 2013;82(4):881-6. PubMed PMID: 23915515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperglycemia, hyperinsulinemia, insulin resistance, and the risk of BPH/LUTS severity and progression over time in community dwelling black men: the Flint Men's Health Study. AU - Wallner,Lauren P, AU - Hollingsworth,John M, AU - Dunn,Rodney L, AU - Kim,Catherine, AU - Herman,William H, AU - Sarma,Aruna V, AU - ,, Y1 - 2013/07/31/ PY - 2012/10/05/received PY - 2013/05/17/revised PY - 2013/05/31/accepted PY - 2013/8/7/entrez PY - 2013/8/7/pubmed PY - 2013/12/16/medline SP - 881 EP - 6 JF - Urology JO - Urology VL - 82 IS - 4 N2 - OBJECTIVE: To examine the associations between fasting serum glucose, insulin concentrations, and insulin resistance and benign prostatic hyperplasia (BPH) in a population-based cohort of African American men. METHODS: Using the Flint Men's Health Study (FMHS), we examined how fasting serum glucose and insulin concentrations and calculated Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) related to burden and progression of clinical markers of BPH in African American men aged 40-79 years. RESULTS: Among 369 men at baseline, mean age was 56.6 years and approximately 70% were overweight/obese (body mass index [BMI] ≥25 kg/m(2)). One hundred forty-eight men (34.4%) reported moderate to severe lower urinary tract symptoms (LUTS) (American Urological Association Symptom Index [AUASI] ≥8). There were no significant trends of metabolic disturbances as measured by serum glucose, insulin, or HOMA-IR in men with indications of BPH compared to those without. CONCLUSION: In this population-based study of African American men aged 40-79 years, we did not observe any significant associations between hyperglycemia, hyperinsulinemia, and insulin resistance and burden and progression of BPH after adjustment for age and BMI. This may be due, in part, to the single measurement of glucose and insulin, which may not adequately reflect average glucose metabolism. Further studies examining measures of long-term glycemic control and BPH in racially diverse populations are warranted. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/23915515/Hyperglycemia_hyperinsulinemia_insulin_resistance_and_the_risk_of_BPH/LUTS_severity_and_progression_over_time_in_community_dwelling_black_men:_the_Flint_Men's_Health_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(13)00695-X DB - PRIME DP - Unbound Medicine ER -