Tags

Type your tag names separated by a space and hit enter

Current and new directions in MRI in multiple sclerosis.
Continuum (Minneap Minn) 2013; 19(4 Multiple Sclerosis):1058-73C

Abstract

PURPOSE OF REVIEW

This article summarizes the use of MRI in the diagnosis and treatment of multiple sclerosis (MS). Current and emerging imaging techniques are reviewed pertaining to their utility in MS.

RECENT FINDINGS

Conventional T1-weighted and T2-weighted sequences are used to identify and characterize disease pathology in MS. T2 lesion burden, postcontrast enhancement, T1 hypointensities, and regional and global atrophy are all informative and correlate to clinical measures, such as disease disability, to a variable extent. Newer techniques such as diffusion tensor imaging, magnetization transfer imaging, and MR spectroscopy are increasingly being incorporated into clinical trials and may provide improved specificity to the underlying pathology. Double inversion recovery and ultrahigh-field-strength MRI have direct application in MS for evaluating cortical pathology. Newer functional MRI techniques such as resting-state functional connectivity are increasingly being applied in MS.

SUMMARY

Conventional and emerging imaging techniques greatly inform our understanding of MS. These techniques are integral in diagnosis, in evaluating new treatments for MS, and for following patients in the clinical setting.

Authors+Show Affiliations

eklawiter@partners.org

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

23917101

Citation

Klawiter, Eric C.. "Current and New Directions in MRI in Multiple Sclerosis." Continuum (Minneapolis, Minn.), vol. 19, no. 4 Multiple Sclerosis, 2013, pp. 1058-73.
Klawiter EC. Current and new directions in MRI in multiple sclerosis. Continuum (Minneap Minn). 2013;19(4 Multiple Sclerosis):1058-73.
Klawiter, E. C. (2013). Current and new directions in MRI in multiple sclerosis. Continuum (Minneapolis, Minn.), 19(4 Multiple Sclerosis), pp. 1058-73. doi:10.1212/01.CON.0000433283.00221.37.
Klawiter EC. Current and New Directions in MRI in Multiple Sclerosis. Continuum (Minneap Minn). 2013;19(4 Multiple Sclerosis):1058-73. PubMed PMID: 23917101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current and new directions in MRI in multiple sclerosis. A1 - Klawiter,Eric C, PY - 2013/8/7/entrez PY - 2013/8/7/pubmed PY - 2014/3/13/medline SP - 1058 EP - 73 JF - Continuum (Minneapolis, Minn.) JO - Continuum (Minneap Minn) VL - 19 IS - 4 Multiple Sclerosis N2 - PURPOSE OF REVIEW: This article summarizes the use of MRI in the diagnosis and treatment of multiple sclerosis (MS). Current and emerging imaging techniques are reviewed pertaining to their utility in MS. RECENT FINDINGS: Conventional T1-weighted and T2-weighted sequences are used to identify and characterize disease pathology in MS. T2 lesion burden, postcontrast enhancement, T1 hypointensities, and regional and global atrophy are all informative and correlate to clinical measures, such as disease disability, to a variable extent. Newer techniques such as diffusion tensor imaging, magnetization transfer imaging, and MR spectroscopy are increasingly being incorporated into clinical trials and may provide improved specificity to the underlying pathology. Double inversion recovery and ultrahigh-field-strength MRI have direct application in MS for evaluating cortical pathology. Newer functional MRI techniques such as resting-state functional connectivity are increasingly being applied in MS. SUMMARY: Conventional and emerging imaging techniques greatly inform our understanding of MS. These techniques are integral in diagnosis, in evaluating new treatments for MS, and for following patients in the clinical setting. SN - 1538-6899 UR - https://www.unboundmedicine.com/medline/citation/23917101/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=23917101 DB - PRIME DP - Unbound Medicine ER -