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Current and new directions in MRI in multiple sclerosis.

Abstract

PURPOSE OF REVIEW

This article summarizes the use of MRI in the diagnosis and treatment of multiple sclerosis (MS). Current and emerging imaging techniques are reviewed pertaining to their utility in MS.

RECENT FINDINGS

Conventional T1-weighted and T2-weighted sequences are used to identify and characterize disease pathology in MS. T2 lesion burden, postcontrast enhancement, T1 hypointensities, and regional and global atrophy are all informative and correlate to clinical measures, such as disease disability, to a variable extent. Newer techniques such as diffusion tensor imaging, magnetization transfer imaging, and MR spectroscopy are increasingly being incorporated into clinical trials and may provide improved specificity to the underlying pathology. Double inversion recovery and ultrahigh-field-strength MRI have direct application in MS for evaluating cortical pathology. Newer functional MRI techniques such as resting-state functional connectivity are increasingly being applied in MS.

SUMMARY

Conventional and emerging imaging techniques greatly inform our understanding of MS. These techniques are integral in diagnosis, in evaluating new treatments for MS, and for following patients in the clinical setting.

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  • Authors+Show Affiliations

    eklawiter@partners.org

    Source

    Continuum (Minneapolis, Minn.) 19:4 Multiple Sclerosis 2013 Aug pg 1058-73

    MeSH

    Adult
    Atrophy
    Brain
    Brain Diseases
    Diplopia
    Female
    Humans
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Multiple Sclerosis
    Neuroimaging
    Spinal Cord Diseases
    Vertigo

    Pub Type(s)

    Case Reports
    Journal Article
    Review

    Language

    eng

    PubMed ID

    23917101

    Citation

    Klawiter, Eric C.. "Current and New Directions in MRI in Multiple Sclerosis." Continuum (Minneapolis, Minn.), vol. 19, no. 4 Multiple Sclerosis, 2013, pp. 1058-73.
    Klawiter EC. Current and new directions in MRI in multiple sclerosis. Continuum (Minneap Minn). 2013;19(4 Multiple Sclerosis):1058-73.
    Klawiter, E. C. (2013). Current and new directions in MRI in multiple sclerosis. Continuum (Minneapolis, Minn.), 19(4 Multiple Sclerosis), pp. 1058-73. doi:10.1212/01.CON.0000433283.00221.37.
    Klawiter EC. Current and New Directions in MRI in Multiple Sclerosis. Continuum (Minneap Minn). 2013;19(4 Multiple Sclerosis):1058-73. PubMed PMID: 23917101.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Current and new directions in MRI in multiple sclerosis. A1 - Klawiter,Eric C, PY - 2013/8/7/entrez PY - 2013/8/7/pubmed PY - 2014/3/13/medline SP - 1058 EP - 73 JF - Continuum (Minneapolis, Minn.) JO - Continuum (Minneap Minn) VL - 19 IS - 4 Multiple Sclerosis N2 - PURPOSE OF REVIEW: This article summarizes the use of MRI in the diagnosis and treatment of multiple sclerosis (MS). Current and emerging imaging techniques are reviewed pertaining to their utility in MS. RECENT FINDINGS: Conventional T1-weighted and T2-weighted sequences are used to identify and characterize disease pathology in MS. T2 lesion burden, postcontrast enhancement, T1 hypointensities, and regional and global atrophy are all informative and correlate to clinical measures, such as disease disability, to a variable extent. Newer techniques such as diffusion tensor imaging, magnetization transfer imaging, and MR spectroscopy are increasingly being incorporated into clinical trials and may provide improved specificity to the underlying pathology. Double inversion recovery and ultrahigh-field-strength MRI have direct application in MS for evaluating cortical pathology. Newer functional MRI techniques such as resting-state functional connectivity are increasingly being applied in MS. SUMMARY: Conventional and emerging imaging techniques greatly inform our understanding of MS. These techniques are integral in diagnosis, in evaluating new treatments for MS, and for following patients in the clinical setting. SN - 1538-6899 UR - https://www.unboundmedicine.com/medline/citation/23917101/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=23917101 DB - PRIME DP - Unbound Medicine ER -