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Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study.
Br J Nutr. 2014 Jan 28; 111(2):301-9.BJ

Abstract

The aims of the present study were to assess the possible differences in faecal microbiota between men with a low serum enterolactone concentration and those with a high concentration, and to investigate the impact of a synbiotic mixture on serum enterolactone concentration in men with a low concentration. We compared faecal microbiota between ten men with the lowest serum enterolactone concentration and ten men with the highest concentration at recruitment (n 84). Furthermore, we carried out a randomised, double-blind, placebo-controlled, cross-over intervention study (6-week intervention periods and 4-week washout period) to investigate the impact of a synbiotic mixture (two Lactobacillus strains, one Bifidobacterium strain, one Propionibacterium strain and galacto-oligosaccharides (32 g/l)) on serum enterolactone concentration in fifty-two men who had a concentration < 20 nmol/l. Serum sensitive C-reactive protein (CRP) concentration was measured at the end of the first intervention period. Men with a low serum enterolactone concentration when compared with those with a high concentration had less faecal bacteria, especially those belonging to the Lactobacillus-Enterococcus group (median 8·2 (interquartile range 7·8-8·4) log10 colony-forming units/g v. median 8·8 (interquartile range 8·5-8·9) log10 colony-forming units/g, P= 0·009). The synbiotic mixture that was used did not have a significant effect on serum enterolactone (synbiotic v. placebo ratio 0·96 (95 % CI 0·76, 1·22), P= 0·724) or serum sensitive CRP (synbiotic v. placebo ratio 0·99 (95 % CI 0·74, 1·33), P= 0·954) concentration. Men with a low serum enterolactone concentration harbour less colonic bacteria, especially those belonging to the Lactobacillus-Enterococcus group. A synbiotic mixture does not increase serum enterolactone concentration.

Authors+Show Affiliations

Institute of Biomedicine, Pharmacology, PO Box 63, FIN-00014 University of Helsinki, Finland.Valio Limited, R&D, PO Box 30, FIN-00039 Helsinki, Finland.Valio Limited, R&D, PO Box 30, FIN-00039 Helsinki, Finland.STAT-Consulting, Vahverokatu 6, FIN-37130 Nokia, Finland.Institute of Biomedicine, Pharmacology, PO Box 63, FIN-00014 University of Helsinki, Finland.Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Center, and Division of Clinical Chemistry, Biomedicum, FIN-00014 University of Helsinki, Finland.Institute of Biomedicine, Pharmacology, PO Box 63, FIN-00014 University of Helsinki, Finland.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23919920

Citation

Holma, Reetta, et al. "Low Serum Enterolactone Concentration Is Associated With Low Colonic Lactobacillus-Enterococcus Counts in Men but Is Not Affected By a Synbiotic Mixture in a Randomised, Placebo-controlled, Double-blind, Cross-over Intervention Study." The British Journal of Nutrition, vol. 111, no. 2, 2014, pp. 301-9.
Holma R, Kekkonen RA, Hatakka K, et al. Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study. Br J Nutr. 2014;111(2):301-9.
Holma, R., Kekkonen, R. A., Hatakka, K., Poussa, T., Vapaatalo, H., Adlercreutz, H., & Korpela, R. (2014). Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study. The British Journal of Nutrition, 111(2), 301-9. https://doi.org/10.1017/S0007114513002420
Holma R, et al. Low Serum Enterolactone Concentration Is Associated With Low Colonic Lactobacillus-Enterococcus Counts in Men but Is Not Affected By a Synbiotic Mixture in a Randomised, Placebo-controlled, Double-blind, Cross-over Intervention Study. Br J Nutr. 2014 Jan 28;111(2):301-9. PubMed PMID: 23919920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study. AU - Holma,Reetta, AU - Kekkonen,Riina A, AU - Hatakka,Katja, AU - Poussa,Tuija, AU - Vapaatalo,Heikki, AU - Adlercreutz,Herman, AU - Korpela,Riitta, Y1 - 2013/08/07/ PY - 2013/8/8/entrez PY - 2013/8/8/pubmed PY - 2014/3/22/medline SP - 301 EP - 9 JF - The British journal of nutrition JO - Br J Nutr VL - 111 IS - 2 N2 - The aims of the present study were to assess the possible differences in faecal microbiota between men with a low serum enterolactone concentration and those with a high concentration, and to investigate the impact of a synbiotic mixture on serum enterolactone concentration in men with a low concentration. We compared faecal microbiota between ten men with the lowest serum enterolactone concentration and ten men with the highest concentration at recruitment (n 84). Furthermore, we carried out a randomised, double-blind, placebo-controlled, cross-over intervention study (6-week intervention periods and 4-week washout period) to investigate the impact of a synbiotic mixture (two Lactobacillus strains, one Bifidobacterium strain, one Propionibacterium strain and galacto-oligosaccharides (32 g/l)) on serum enterolactone concentration in fifty-two men who had a concentration < 20 nmol/l. Serum sensitive C-reactive protein (CRP) concentration was measured at the end of the first intervention period. Men with a low serum enterolactone concentration when compared with those with a high concentration had less faecal bacteria, especially those belonging to the Lactobacillus-Enterococcus group (median 8·2 (interquartile range 7·8-8·4) log10 colony-forming units/g v. median 8·8 (interquartile range 8·5-8·9) log10 colony-forming units/g, P= 0·009). The synbiotic mixture that was used did not have a significant effect on serum enterolactone (synbiotic v. placebo ratio 0·96 (95 % CI 0·76, 1·22), P= 0·724) or serum sensitive CRP (synbiotic v. placebo ratio 0·99 (95 % CI 0·74, 1·33), P= 0·954) concentration. Men with a low serum enterolactone concentration harbour less colonic bacteria, especially those belonging to the Lactobacillus-Enterococcus group. A synbiotic mixture does not increase serum enterolactone concentration. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/23919920/Low_serum_enterolactone_concentration_is_associated_with_low_colonic_Lactobacillus_Enterococcus_counts_in_men_but_is_not_affected_by_a_synbiotic_mixture_in_a_randomised_placebo_controlled_double_blind_cross_over_intervention_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114513002420/type/journal_article DB - PRIME DP - Unbound Medicine ER -