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Changing patterns of disseminated gonococcal infection in France: cross-sectional data 2009-2011.
Sex Transm Infect. 2013 Dec; 89(8):613-5.ST

Abstract

OBJECTIVES

Disseminated gonococcal infections (DGIs) are rare. We describe the characteristics of DGIs in France.

METHODS

This is a 3-year retrospective analysis of DGI cases collected through two networks of microbiologists and infectious disease specialists in France between 2009 and 2011. DGI was defined either by the isolation of Neisseria gonorrhoeae from blood and synovial fluid or by the existence of a clinical syndrome consistent with DGI and the isolation of N gonorrhoeae from any site. We describe the epidemiological, clinical and microbiological characteristics and outcomes of DGIs.

RESULTS

21 patients (9 women, 12 men; 18-62 years old) were diagnosed with DGI. The number of DGI cases increased between 2009 and 2011. Two men who had sex with men were coinfected with HIV. We found 28 extragenital locations, including arthritis (14 cases), tenosynovitis (7), skin lesions (4), endocarditis (1), prostatitis (1) and pelvic inflammatory disease (1). Genital signs were present in five patients. The diagnosis was confirmed by cultures in 20 patients-blood (4), synovial fluid (11), genital (3), throat (1), urine (1)-and by molecular biology on a pharyngeal swab in 1 patient. Seven cases were resistant to fluoroquinolones. The patients were treated with ceftriaxone, associated with corticosteroids (two cases) and surgery (six cases). Four patients had joint sequelae.

CONCLUSIONS

DGIs are increasing. Men seem to be at higher risk than women. Joint involvement was common. Microbiological diagnosis was based on culture, however molecular biology using pharyngeal swabs was helpful when cultures were negative.

Authors+Show Affiliations

Department of Infectious and Tropical Diseases, Centre Hospitalier Intercommunal, , Villeneuve Saint Georges, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23920397

Citation

Belkacem, Anna, et al. "Changing Patterns of Disseminated Gonococcal Infection in France: Cross-sectional Data 2009-2011." Sexually Transmitted Infections, vol. 89, no. 8, 2013, pp. 613-5.
Belkacem A, Caumes E, Ouanich J, et al. Changing patterns of disseminated gonococcal infection in France: cross-sectional data 2009-2011. Sex Transm Infect. 2013;89(8):613-5.
Belkacem, A., Caumes, E., Ouanich, J., Jarlier, V., Dellion, S., Cazenave, B., Goursaud, R., Lacassin, F., Breuil, J., & Patey, O. (2013). Changing patterns of disseminated gonococcal infection in France: cross-sectional data 2009-2011. Sexually Transmitted Infections, 89(8), 613-5. https://doi.org/10.1136/sextrans-2013-051119
Belkacem A, et al. Changing Patterns of Disseminated Gonococcal Infection in France: Cross-sectional Data 2009-2011. Sex Transm Infect. 2013;89(8):613-5. PubMed PMID: 23920397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changing patterns of disseminated gonococcal infection in France: cross-sectional data 2009-2011. AU - Belkacem,Anna, AU - Caumes,Eric, AU - Ouanich,Jocelyne, AU - Jarlier,Vincent, AU - Dellion,Sophie, AU - Cazenave,Benoit, AU - Goursaud,Régis, AU - Lacassin,Flore, AU - Breuil,Jacques, AU - Patey,Olivier, AU - ,, Y1 - 2013/08/06/ PY - 2013/8/8/entrez PY - 2013/8/8/pubmed PY - 2014/1/29/medline KW - DERMATOLOGY KW - EPIDEMIOLOGY (CLINICAL) KW - GONOCOCCI KW - NEISSERIA GONORRHOEA SP - 613 EP - 5 JF - Sexually transmitted infections JO - Sex Transm Infect VL - 89 IS - 8 N2 - OBJECTIVES: Disseminated gonococcal infections (DGIs) are rare. We describe the characteristics of DGIs in France. METHODS: This is a 3-year retrospective analysis of DGI cases collected through two networks of microbiologists and infectious disease specialists in France between 2009 and 2011. DGI was defined either by the isolation of Neisseria gonorrhoeae from blood and synovial fluid or by the existence of a clinical syndrome consistent with DGI and the isolation of N gonorrhoeae from any site. We describe the epidemiological, clinical and microbiological characteristics and outcomes of DGIs. RESULTS: 21 patients (9 women, 12 men; 18-62 years old) were diagnosed with DGI. The number of DGI cases increased between 2009 and 2011. Two men who had sex with men were coinfected with HIV. We found 28 extragenital locations, including arthritis (14 cases), tenosynovitis (7), skin lesions (4), endocarditis (1), prostatitis (1) and pelvic inflammatory disease (1). Genital signs were present in five patients. The diagnosis was confirmed by cultures in 20 patients-blood (4), synovial fluid (11), genital (3), throat (1), urine (1)-and by molecular biology on a pharyngeal swab in 1 patient. Seven cases were resistant to fluoroquinolones. The patients were treated with ceftriaxone, associated with corticosteroids (two cases) and surgery (six cases). Four patients had joint sequelae. CONCLUSIONS: DGIs are increasing. Men seem to be at higher risk than women. Joint involvement was common. Microbiological diagnosis was based on culture, however molecular biology using pharyngeal swabs was helpful when cultures were negative. SN - 1472-3263 UR - https://www.unboundmedicine.com/medline/citation/23920397/Changing_patterns_of_disseminated_gonococcal_infection_in_France:_cross_sectional_data_2009_2011_ L2 - http://sti.bmj.com/cgi/pmidlookup?view=long&pmid=23920397 DB - PRIME DP - Unbound Medicine ER -