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Molecular and physiological functions of sphingosine 1-phosphate transporters.
Biochim Biophys Acta 2014; 1841(5):759-65BB

Abstract

Sphingosine 1-phosphate (S1P) is a lipid mediator that plays important roles in diverse cellular functions such as cell proliferation, differentiation and migration. S1P is synthesized inside the cells and subsequently released to the extracellular space, where it binds to specific receptors that are located on the plasma membranes of target cells. Accumulating recent evidence suggests that S1P transporters including SPNS2 mediate S1P release from the cells and are involved in the physiological functions of S1P. In this review, we discuss recent advances in our understanding of the mechanism and physiological functions of S1P transporters. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.

Authors+Show Affiliations

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan; Faculty of Pharmaceutical Science, Osaka University, Suita, Osaka 565-0871, Japan. Electronic address: tnishi@sanken.osaka-u.ac.jp.Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan.Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan; Laboratory for Cardiovascular Molecular Dynamics, RIKEN Quantitative Biology Center (QBiC), Suita, Osaka 565-0874, Japan.Laboratory for Cardiovascular Molecular Dynamics, RIKEN Quantitative Biology Center (QBiC), Suita, Osaka 565-0874, Japan.Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan; Faculty of Pharmaceutical Science, Osaka University, Suita, Osaka 565-0871, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23921254

Citation

Nishi, Tsuyoshi, et al. "Molecular and Physiological Functions of Sphingosine 1-phosphate Transporters." Biochimica Et Biophysica Acta, vol. 1841, no. 5, 2014, pp. 759-65.
Nishi T, Kobayashi N, Hisano Y, et al. Molecular and physiological functions of sphingosine 1-phosphate transporters. Biochim Biophys Acta. 2014;1841(5):759-65.
Nishi, T., Kobayashi, N., Hisano, Y., Kawahara, A., & Yamaguchi, A. (2014). Molecular and physiological functions of sphingosine 1-phosphate transporters. Biochimica Et Biophysica Acta, 1841(5), pp. 759-65. doi:10.1016/j.bbalip.2013.07.012.
Nishi T, et al. Molecular and Physiological Functions of Sphingosine 1-phosphate Transporters. Biochim Biophys Acta. 2014;1841(5):759-65. PubMed PMID: 23921254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular and physiological functions of sphingosine 1-phosphate transporters. AU - Nishi,Tsuyoshi, AU - Kobayashi,Naoki, AU - Hisano,Yu, AU - Kawahara,Atsuo, AU - Yamaguchi,Akihito, Y1 - 2013/08/04/ PY - 2013/06/01/received PY - 2013/07/26/revised PY - 2013/07/29/accepted PY - 2013/8/8/entrez PY - 2013/8/8/pubmed PY - 2014/6/4/medline KW - ABC transporter KW - Export KW - SPNS2 KW - Sphingosine 1-phosphate KW - Transporter SP - 759 EP - 65 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1841 IS - 5 N2 - Sphingosine 1-phosphate (S1P) is a lipid mediator that plays important roles in diverse cellular functions such as cell proliferation, differentiation and migration. S1P is synthesized inside the cells and subsequently released to the extracellular space, where it binds to specific receptors that are located on the plasma membranes of target cells. Accumulating recent evidence suggests that S1P transporters including SPNS2 mediate S1P release from the cells and are involved in the physiological functions of S1P. In this review, we discuss recent advances in our understanding of the mechanism and physiological functions of S1P transporters. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/23921254/Molecular_and_physiological_functions_of_sphingosine_1_phosphate_transporters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-1981(13)00150-9 DB - PRIME DP - Unbound Medicine ER -