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[Acute fatty degeneration of the liver in pregnancy].
Ned Tijdschr Geneeskd. 1990 Aug 11; 134(32):1558-61.NT

Abstract

Acute fatty liver of pregnancy is considered an uncommon disorder that may complicate the third trimester of pregnancy, with high fetal and maternal mortality rates. However, in recent years it has become clear that the course of the disorder can be less fulminant than previously believed. The diagnosis is also made more frequently. The case histories of three patients are described followed by a review of the clinical and diagnostic features. It is concluded that with all women showing symptoms of malaise, nausea, vomiting and upper abdominal pain in the third trimester of pregnancy liver enzymes should be measured. If evidence of liver dysfunction is found, acute fatty liver of pregnancy should be considered in the differential diagnosis. Only early recognition and prompt treatment will improve both fetal and maternal survival.

Authors+Show Affiliations

Schueler JA
Afd. Gynaecologie en Obstetrie, Ziekenhuis Leyenburg, CH's-Gravenhage.
Van De Lubbe PA
No affiliation info available
Van Erp EJ
No affiliation info available
Smith SJ
No affiliation info available
Holm JP
No affiliation info available

MeSH

AdultDisseminated Intravascular CoagulationFatty LiverFemaleHumansLiver Function TestsPregnancyPregnancy Complications

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

dut

PubMed ID

2392179

Citation

Schueler, J A., et al. "[Acute Fatty Degeneration of the Liver in Pregnancy]." Nederlands Tijdschrift Voor Geneeskunde, vol. 134, no. 32, 1990, pp. 1558-61.
Schueler JA, Van De Lubbe PA, Van Erp EJ, et al. [Acute fatty degeneration of the liver in pregnancy]. Ned Tijdschr Geneeskd. 1990;134(32):1558-61.
Schueler, J. A., Van De Lubbe, P. A., Van Erp, E. J., Smith, S. J., & Holm, J. P. (1990). [Acute fatty degeneration of the liver in pregnancy]. Nederlands Tijdschrift Voor Geneeskunde, 134(32), 1558-61.
Schueler JA, et al. [Acute Fatty Degeneration of the Liver in Pregnancy]. Ned Tijdschr Geneeskd. 1990 Aug 11;134(32):1558-61. PubMed PMID: 2392179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute fatty degeneration of the liver in pregnancy]. AU - Schueler,J A, AU - Van De Lubbe,P A, AU - Van Erp,E J, AU - Smith,S J, AU - Holm,J P, PY - 1990/8/11/pubmed PY - 1990/8/11/medline PY - 1990/8/11/entrez SP - 1558 EP - 61 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 134 IS - 32 N2 - Acute fatty liver of pregnancy is considered an uncommon disorder that may complicate the third trimester of pregnancy, with high fetal and maternal mortality rates. However, in recent years it has become clear that the course of the disorder can be less fulminant than previously believed. The diagnosis is also made more frequently. The case histories of three patients are described followed by a review of the clinical and diagnostic features. It is concluded that with all women showing symptoms of malaise, nausea, vomiting and upper abdominal pain in the third trimester of pregnancy liver enzymes should be measured. If evidence of liver dysfunction is found, acute fatty liver of pregnancy should be considered in the differential diagnosis. Only early recognition and prompt treatment will improve both fetal and maternal survival. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/2392179/[Acute_fatty_degeneration_of_the_liver_in_pregnancy]_ DB - PRIME DP - Unbound Medicine ER -