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Effect of water soluble carrier on dissolution profiles of diclofenac sodium.
Acta Pol Pharm. 2013 Jul-Aug; 70(4):721-6.AP

Abstract

Pharmaceutical aviailability of diclofenac sodium from solid dispersions of PEG 6000 have been studied in comparison to those of the corresponding physical mixtures and pure diclofenac sodium. The diclofenac sodium is poorly water soluble drug. The properties of diclofenac sodium-PEG 6000 solid dispersions have been determined by the methods of differential scanning calorimetry (DSC), X-ray diffraction and scanning electron microscopy (SEM). The effect of PEG 6000 on the solubility of selected diclofenac sodium dispersions has been studied. The solubility of diclofenac sodium from its solid dispersion has been found to increase in the presence of PEG 6000.

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Authors+Show Affiliations

Cwiertnia B
Poznan University of Medical Sciences, Department of Inorganic and Analytical Chemistry, 6 Grunwaldzka St., 60-780 Poznań, Poland. cbarbara@interia.pl

MeSH

Anti-Inflammatory Agents, Non-SteroidalChemistry, PharmaceuticalDiclofenacDrug CarriersPolyethylene GlycolsSolubilitySolventsTechnology, PharmaceuticalWater

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23923395

Citation

Cwiertnia, Barbara. "Effect of Water Soluble Carrier On Dissolution Profiles of Diclofenac Sodium." Acta Poloniae Pharmaceutica, vol. 70, no. 4, 2013, pp. 721-6.
Cwiertnia B. Effect of water soluble carrier on dissolution profiles of diclofenac sodium. Acta Pol Pharm. 2013;70(4):721-6.
Cwiertnia, B. (2013). Effect of water soluble carrier on dissolution profiles of diclofenac sodium. Acta Poloniae Pharmaceutica, 70(4), 721-6.
Cwiertnia B. Effect of Water Soluble Carrier On Dissolution Profiles of Diclofenac Sodium. Acta Pol Pharm. 2013 Jul-Aug;70(4):721-6. PubMed PMID: 23923395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of water soluble carrier on dissolution profiles of diclofenac sodium. A1 - Cwiertnia,Barbara, PY - 2013/8/8/entrez PY - 2013/8/8/pubmed PY - 2013/9/11/medline SP - 721 EP - 6 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 70 IS - 4 N2 - Pharmaceutical aviailability of diclofenac sodium from solid dispersions of PEG 6000 have been studied in comparison to those of the corresponding physical mixtures and pure diclofenac sodium. The diclofenac sodium is poorly water soluble drug. The properties of diclofenac sodium-PEG 6000 solid dispersions have been determined by the methods of differential scanning calorimetry (DSC), X-ray diffraction and scanning electron microscopy (SEM). The effect of PEG 6000 on the solubility of selected diclofenac sodium dispersions has been studied. The solubility of diclofenac sodium from its solid dispersion has been found to increase in the presence of PEG 6000. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/23923395/Effect_of_water_soluble_carrier_on_dissolution_profiles_of_diclofenac_sodium_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2013/4/721.pdf DB - PRIME DP - Unbound Medicine ER -