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Evaluation of hepatoprotective potential of propolis extract in carbon tetrachloride induced liver injury in rats.
Indian J Biochem Biophys. 2005 Oct; 42(5):321-5.IJ

Abstract

Propolis (bee glue), a resinous wax-like beehive product has been used since ancient times for its pharmaceutical properties. In the present study, the ethanolic extract of propolis (50, 100, 200 and 400 mg/kg, p.o.) was studied for its hepatoprotective activity against carbon tetrachloride (CCl4, 1.5 ml/kg, i.p.) induced liver damage in rats. Administration of CCl4 caused a sharp elevation in the activity of serum transaminases, serum alkaline phosphatase, acid phosphatase and hepatic lipid peroxidation (LPO) levels, and a significant decrease in the ATPase, alkaline phosphatase and succinic dehydrogenase activities in the liver and kidney and hepatic GSH level. The treatment with propolis extract at the doses of 200 and 400 mg/kg significantly reversed the various biochemical alterations in blood, liver and kidney induced by CCl4 intoxication. The hepatoprotective property of propolis may be due to its antioxidant activity.

Authors+Show Affiliations

Shukla S
School of Studies in Zoology, Jiwaji University, Gwalior (MP), India. dr_sshukla@hotmail.com
Bhadauria M
No affiliation info available
Jadon A
No affiliation info available

MeSH

Adenosine TriphosphatasesAlkaline PhosphataseAnimalsCarbon TetrachlorideCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryFemaleGlutathioneLipid PeroxidationLiver Function TestsPhytotherapyPlant ExtractsPropolisRatsRats, Sprague-DawleySuccinate Dehydrogenase

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23923541

Citation

Shukla, Sangeeta, et al. "Evaluation of Hepatoprotective Potential of Propolis Extract in Carbon Tetrachloride Induced Liver Injury in Rats." Indian Journal of Biochemistry & Biophysics, vol. 42, no. 5, 2005, pp. 321-5.
Shukla S, Bhadauria M, Jadon A. Evaluation of hepatoprotective potential of propolis extract in carbon tetrachloride induced liver injury in rats. Indian J Biochem Biophys. 2005;42(5):321-5.
Shukla, S., Bhadauria, M., & Jadon, A. (2005). Evaluation of hepatoprotective potential of propolis extract in carbon tetrachloride induced liver injury in rats. Indian Journal of Biochemistry & Biophysics, 42(5), 321-5.
Shukla S, Bhadauria M, Jadon A. Evaluation of Hepatoprotective Potential of Propolis Extract in Carbon Tetrachloride Induced Liver Injury in Rats. Indian J Biochem Biophys. 2005;42(5):321-5. PubMed PMID: 23923541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of hepatoprotective potential of propolis extract in carbon tetrachloride induced liver injury in rats. AU - Shukla,Sangeeta, AU - Bhadauria,Monika, AU - Jadon,Anjana, PY - 2013/8/9/entrez PY - 2005/10/1/pubmed PY - 2013/8/27/medline SP - 321 EP - 5 JF - Indian journal of biochemistry & biophysics JO - Indian J Biochem Biophys VL - 42 IS - 5 N2 - Propolis (bee glue), a resinous wax-like beehive product has been used since ancient times for its pharmaceutical properties. In the present study, the ethanolic extract of propolis (50, 100, 200 and 400 mg/kg, p.o.) was studied for its hepatoprotective activity against carbon tetrachloride (CCl4, 1.5 ml/kg, i.p.) induced liver damage in rats. Administration of CCl4 caused a sharp elevation in the activity of serum transaminases, serum alkaline phosphatase, acid phosphatase and hepatic lipid peroxidation (LPO) levels, and a significant decrease in the ATPase, alkaline phosphatase and succinic dehydrogenase activities in the liver and kidney and hepatic GSH level. The treatment with propolis extract at the doses of 200 and 400 mg/kg significantly reversed the various biochemical alterations in blood, liver and kidney induced by CCl4 intoxication. The hepatoprotective property of propolis may be due to its antioxidant activity. SN - 0301-1208 UR - https://www.unboundmedicine.com/medline/citation/23923541/Evaluation_of_hepatoprotective_potential_of_propolis_extract_in_carbon_tetrachloride_induced_liver_injury_in_rats_ DB - PRIME DP - Unbound Medicine ER -