Tags

Type your tag names separated by a space and hit enter

Galactosemia in the Turkish population with a high frequency of Q188R mutation and distribution of Duarte-1 and Duarte-2 variations.
J Hum Genet. 2013 Oct; 58(10):675-8.JH

Abstract

Classical galactosemia is an inherited recessive disorder of galactose metabolism caused by deficiency of the enzyme galactose-1-phosphate uridyl transferase (GALT), which is caused by mutations in the GALT gene. In this study, 56 Turkish patients diagnosed with galactosemia were screened for GALT gene mutations using Affymetrix resequencing microarrays. Eleven types of mutations were detected in these patients, including two novel mutations (R258G and G310fsX49) and nine recurrent mutations. We detected six patients who were homozygous for the E340* mutation and for N314D, L218L silent substitutions (Duarte-1 variant) in this study. The haplotype E340*, N314D and L218L has been reported only in Turkish patients, which suggests that the E340* mutation is specific for our population and might be spread by a Turk ancestor. In patients, the Duarte-1 allele was found with a frequency of 10.71%, whereas the Duarte-2 allele was not detected. Duarte-1 and Duarte-2 alleles were found to be present at a frequency of 2.3% and 1.4%, respectively, in the screening of 105 healthy individuals. Considering all detected mutations, it is a very important finding that exons 6 and 10 of the GALT gene account for 79% of all mutant alleles in the Turkish population. The most common mutation is Q188R, with a frequency of 55.35%.

Authors+Show Affiliations

1] Metabolism Unit, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey [2] Institute of Child Health, Hacettepe University, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23924834

Citation

Özgül, Rıza Köksal, et al. "Galactosemia in the Turkish Population With a High Frequency of Q188R Mutation and Distribution of Duarte-1 and Duarte-2 Variations." Journal of Human Genetics, vol. 58, no. 10, 2013, pp. 675-8.
Özgül RK, Güzel-Ozantürk A, Dündar H, et al. Galactosemia in the Turkish population with a high frequency of Q188R mutation and distribution of Duarte-1 and Duarte-2 variations. J Hum Genet. 2013;58(10):675-8.
Özgül, R. K., Güzel-Ozantürk, A., Dündar, H., Yücel-Yılmaz, D., Coşkun, T., Sivri, S., Aydoǧdu, S., Tokatlı, A., & Dursun, A. (2013). Galactosemia in the Turkish population with a high frequency of Q188R mutation and distribution of Duarte-1 and Duarte-2 variations. Journal of Human Genetics, 58(10), 675-8. https://doi.org/10.1038/jhg.2013.76
Özgül RK, et al. Galactosemia in the Turkish Population With a High Frequency of Q188R Mutation and Distribution of Duarte-1 and Duarte-2 Variations. J Hum Genet. 2013;58(10):675-8. PubMed PMID: 23924834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Galactosemia in the Turkish population with a high frequency of Q188R mutation and distribution of Duarte-1 and Duarte-2 variations. AU - Özgül,Rıza Köksal, AU - Güzel-Ozantürk,Ayşegül, AU - Dündar,Halil, AU - Yücel-Yılmaz,Didem, AU - Coşkun,Turgay, AU - Sivri,Serap, AU - Aydoǧdu,Sultan, AU - Tokatlı,Ayşegül, AU - Dursun,Ali, Y1 - 2013/08/08/ PY - 2013/04/24/received PY - 2013/06/04/revised PY - 2013/07/01/accepted PY - 2013/8/9/entrez PY - 2013/8/9/pubmed PY - 2014/4/22/medline SP - 675 EP - 8 JF - Journal of human genetics JO - J Hum Genet VL - 58 IS - 10 N2 - Classical galactosemia is an inherited recessive disorder of galactose metabolism caused by deficiency of the enzyme galactose-1-phosphate uridyl transferase (GALT), which is caused by mutations in the GALT gene. In this study, 56 Turkish patients diagnosed with galactosemia were screened for GALT gene mutations using Affymetrix resequencing microarrays. Eleven types of mutations were detected in these patients, including two novel mutations (R258G and G310fsX49) and nine recurrent mutations. We detected six patients who were homozygous for the E340* mutation and for N314D, L218L silent substitutions (Duarte-1 variant) in this study. The haplotype E340*, N314D and L218L has been reported only in Turkish patients, which suggests that the E340* mutation is specific for our population and might be spread by a Turk ancestor. In patients, the Duarte-1 allele was found with a frequency of 10.71%, whereas the Duarte-2 allele was not detected. Duarte-1 and Duarte-2 alleles were found to be present at a frequency of 2.3% and 1.4%, respectively, in the screening of 105 healthy individuals. Considering all detected mutations, it is a very important finding that exons 6 and 10 of the GALT gene account for 79% of all mutant alleles in the Turkish population. The most common mutation is Q188R, with a frequency of 55.35%. SN - 1435-232X UR - https://www.unboundmedicine.com/medline/citation/23924834/Galactosemia_in_the_Turkish_population_with_a_high_frequency_of_Q188R_mutation_and_distribution_of_Duarte_1_and_Duarte_2_variations_ DB - PRIME DP - Unbound Medicine ER -