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Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats.
J Diet Suppl. 2013 Sep; 10(3):195-209.JD

Abstract

Ginger is a remedy known to possess a number of pharmacological properties. This study investigated efficacy of ginger pretreatment in alleviating acetaminophen-induced acute hepatotoxicity in rats. Rats were divided into six groups; negative control, acetaminophen (APAP) (600 mg/kg single intraperitoneal injection); vitamin E (75 mg/kg), ginger (100 mg/kg), vitamin E + APAP, and ginger + APAP. Administration of APAP elicited significant liver injury that was manifested by remarkable increase in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), arginase activities, and total bilirubin concentration. Meanwhile, APAP significantly decreased plasma total proteins and albumin levels. APAP administration resulted in substantial increase in each of plasma triacylglycerols (TAGs), malondialdhyde (MDA) levels, and total antioxidant capacity (TAC). However, ginger or vitamin E treatment prior to APAP showed significant hepatoprotective effect by lowering the hepatic marker enzymes (AST, ALT, ALP, and arginase) and total bilirubin in plasma. In addition, they remarkably ameliorated the APAP-induced oxidative stress by inhibiting lipid peroxidation (MDA). Pretreatment by ginger or vitamin E significantly restored TAGs, and total protein levels. Histopathological examination of APAP treated rats showed alterations in normal hepatic histoarchitecture, with necrosis and vacuolization of cells. These alterations were substantially decreased by ginger or vitamin E. Our results demonstrated that ginger can prevent hepatic injuries, alleviating oxidative stress in a manner comparable to that of vitamin E. Combination therapy of ginger and APAP is recommended especially in cases with hepatic disorders or when high doses of APAP are required.

Authors+Show Affiliations

Department of Food Science & Nutrition, National Research Centre, Dokki, Cairo, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23927622

Citation

Abdel-Azeem, Amal S., et al. "Hepatoprotective, Antioxidant, and Ameliorative Effects of Ginger (Zingiber Officinale Roscoe) and Vitamin E in Acetaminophen Treated Rats." Journal of Dietary Supplements, vol. 10, no. 3, 2013, pp. 195-209.
Abdel-Azeem AS, Hegazy AM, Ibrahim KS, et al. Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats. J Diet Suppl. 2013;10(3):195-209.
Abdel-Azeem, A. S., Hegazy, A. M., Ibrahim, K. S., Farrag, A. R., & El-Sayed, E. M. (2013). Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats. Journal of Dietary Supplements, 10(3), 195-209. https://doi.org/10.3109/19390211.2013.822450
Abdel-Azeem AS, et al. Hepatoprotective, Antioxidant, and Ameliorative Effects of Ginger (Zingiber Officinale Roscoe) and Vitamin E in Acetaminophen Treated Rats. J Diet Suppl. 2013;10(3):195-209. PubMed PMID: 23927622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats. AU - Abdel-Azeem,Amal S, AU - Hegazy,Amany M, AU - Ibrahim,Khadiga S, AU - Farrag,Abdel-Razik H, AU - El-Sayed,Eman M, Y1 - 2013/08/09/ PY - 2013/8/10/entrez PY - 2013/8/10/pubmed PY - 2014/3/4/medline SP - 195 EP - 209 JF - Journal of dietary supplements JO - J Diet Suppl VL - 10 IS - 3 N2 - Ginger is a remedy known to possess a number of pharmacological properties. This study investigated efficacy of ginger pretreatment in alleviating acetaminophen-induced acute hepatotoxicity in rats. Rats were divided into six groups; negative control, acetaminophen (APAP) (600 mg/kg single intraperitoneal injection); vitamin E (75 mg/kg), ginger (100 mg/kg), vitamin E + APAP, and ginger + APAP. Administration of APAP elicited significant liver injury that was manifested by remarkable increase in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), arginase activities, and total bilirubin concentration. Meanwhile, APAP significantly decreased plasma total proteins and albumin levels. APAP administration resulted in substantial increase in each of plasma triacylglycerols (TAGs), malondialdhyde (MDA) levels, and total antioxidant capacity (TAC). However, ginger or vitamin E treatment prior to APAP showed significant hepatoprotective effect by lowering the hepatic marker enzymes (AST, ALT, ALP, and arginase) and total bilirubin in plasma. In addition, they remarkably ameliorated the APAP-induced oxidative stress by inhibiting lipid peroxidation (MDA). Pretreatment by ginger or vitamin E significantly restored TAGs, and total protein levels. Histopathological examination of APAP treated rats showed alterations in normal hepatic histoarchitecture, with necrosis and vacuolization of cells. These alterations were substantially decreased by ginger or vitamin E. Our results demonstrated that ginger can prevent hepatic injuries, alleviating oxidative stress in a manner comparable to that of vitamin E. Combination therapy of ginger and APAP is recommended especially in cases with hepatic disorders or when high doses of APAP are required. SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/23927622/Hepatoprotective_antioxidant_and_ameliorative_effects_of_ginger__Zingiber_officinale_Roscoe__and_vitamin_E_in_acetaminophen_treated_rats_ L2 - http://www.tandfonline.com/doi/full/10.3109/19390211.2013.822450 DB - PRIME DP - Unbound Medicine ER -