Tags

Type your tag names separated by a space and hit enter

The endocannabinoid system and emotional processing: a pharmacological fMRI study with ∆9-tetrahydrocannabinol.
Eur Neuropsychopharmacol 2013; 23(12):1687-97EN

Abstract

Various psychiatric disorders such as major depression are associated with abnormalities in emotional processing. Evidence indicating involvement of the endocannabinoid system in emotional processing, and thus potentially in related abnormalities, is increasing. In the present study, we examined the role of the endocannabinoid system in processing of stimuli with a positive and negative emotional content in healthy volunteers. A pharmacological functional magnetic resonance imaging (fMRI) study was conducted with a placebo-controlled, cross-over design, investigating effects of the endocannabinoid agonist ∆9-tetrahydrocannabinol (THC) on brain function related to emotional processing in 11 healthy subjects. Performance and brain activity during matching of stimuli with a negative ('fearful faces') or a positive content ('happy faces') were assessed after placebo and THC administration. After THC administration, performance accuracy was decreased for stimuli with a negative but not for stimuli with a positive emotional content. Our task activated a network of brain regions including amygdala, orbital frontal gyrus, hippocampus, parietal gyrus, prefrontal cortex, and regions in the occipital cortex. THC interacted with emotional content, as activity in this network was reduced for negative content, while activity for positive content was increased. These results indicate that THC administration reduces the negative bias in emotional processing. This adds human evidence to support the hypothesis that the endocannabinoid system is involved in modulation of emotional processing. Our findings also suggest a possible role for the endocannabinoid system in abnormal emotional processing, and may thus be relevant for psychiatric disorders such as major depression.

Authors+Show Affiliations

Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Institute of Psychiatry, Department of Psychosis Studies (PO67), King's College London, 16 De Crespigny Park, London SE5 8AF, United Kingdom. Electronic address: matthijs.bossong@kcl.ac.uk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23928295

Citation

Bossong, Matthijs G., et al. "The Endocannabinoid System and Emotional Processing: a Pharmacological fMRI Study With ∆9-tetrahydrocannabinol." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 23, no. 12, 2013, pp. 1687-97.
Bossong MG, van Hell HH, Jager G, et al. The endocannabinoid system and emotional processing: a pharmacological fMRI study with ∆9-tetrahydrocannabinol. Eur Neuropsychopharmacol. 2013;23(12):1687-97.
Bossong, M. G., van Hell, H. H., Jager, G., Kahn, R. S., Ramsey, N. F., & Jansma, J. M. (2013). The endocannabinoid system and emotional processing: a pharmacological fMRI study with ∆9-tetrahydrocannabinol. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 23(12), pp. 1687-97. doi:10.1016/j.euroneuro.2013.06.009.
Bossong MG, et al. The Endocannabinoid System and Emotional Processing: a Pharmacological fMRI Study With ∆9-tetrahydrocannabinol. Eur Neuropsychopharmacol. 2013;23(12):1687-97. PubMed PMID: 23928295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system and emotional processing: a pharmacological fMRI study with ∆9-tetrahydrocannabinol. AU - Bossong,Matthijs G, AU - van Hell,Hendrika H, AU - Jager,Gerry, AU - Kahn,René S, AU - Ramsey,Nick F, AU - Jansma,J Martijn, Y1 - 2013/08/06/ PY - 2012/12/03/received PY - 2013/06/05/revised PY - 2013/06/24/accepted PY - 2013/8/10/entrez PY - 2013/8/10/pubmed PY - 2014/7/6/medline KW - Emotional processing KW - Endocannabinoid system KW - Functional MRI KW - Δ9-tetrahydrocannabinol (THC) SP - 1687 EP - 97 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 23 IS - 12 N2 - Various psychiatric disorders such as major depression are associated with abnormalities in emotional processing. Evidence indicating involvement of the endocannabinoid system in emotional processing, and thus potentially in related abnormalities, is increasing. In the present study, we examined the role of the endocannabinoid system in processing of stimuli with a positive and negative emotional content in healthy volunteers. A pharmacological functional magnetic resonance imaging (fMRI) study was conducted with a placebo-controlled, cross-over design, investigating effects of the endocannabinoid agonist ∆9-tetrahydrocannabinol (THC) on brain function related to emotional processing in 11 healthy subjects. Performance and brain activity during matching of stimuli with a negative ('fearful faces') or a positive content ('happy faces') were assessed after placebo and THC administration. After THC administration, performance accuracy was decreased for stimuli with a negative but not for stimuli with a positive emotional content. Our task activated a network of brain regions including amygdala, orbital frontal gyrus, hippocampus, parietal gyrus, prefrontal cortex, and regions in the occipital cortex. THC interacted with emotional content, as activity in this network was reduced for negative content, while activity for positive content was increased. These results indicate that THC administration reduces the negative bias in emotional processing. This adds human evidence to support the hypothesis that the endocannabinoid system is involved in modulation of emotional processing. Our findings also suggest a possible role for the endocannabinoid system in abnormal emotional processing, and may thus be relevant for psychiatric disorders such as major depression. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/23928295/The_endocannabinoid_system_and_emotional_processing:_a_pharmacological_fMRI_study_with_∆9_tetrahydrocannabinol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(13)00195-8 DB - PRIME DP - Unbound Medicine ER -