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Heritability of substance use in the NAS-NRC Twin Registry.

Abstract

This study examines the heritability of cigarette smoking, alcohol, and coffee consumption in 4,960 adult, male twin pairs (2,390 MZ and 2,570 DZ pairs) participants in an epidemiologic survey of the NAS-NRC Twin Registry conducted in the USA during 1972-73. Heritability estimates for smoking, alcohol and coffee use were calculated both before and after adjustment for shared variance between these behaviors and other demographic characteristics including socioeconomic status and an occupational adjustment score. The objective of the analysis was to determine the impact of adjustment for covariates on heritability estimates of smoking, alcohol and coffee use. Before adjustment, genetic effects in smoking, alcohol and coffee use accounted for 53%, 36%, and 45% of the variance, respectively. After adjustment, the corresponding estimates were 35%, 29%, and 36%. The fact that these estimates remained significant after adjustment for covariates leads to increased confidence about the role of genetic factors in substance use behaviors.

Authors+Show Affiliations

SRI International, Menlo Park, California.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2392895

Citation

Carmelli, D, et al. "Heritability of Substance Use in the NAS-NRC Twin Registry." Acta Geneticae Medicae Et Gemellologiae, vol. 39, no. 1, 1990, pp. 91-8.
Carmelli D, Swan GE, Robinette D, et al. Heritability of substance use in the NAS-NRC Twin Registry. Acta Genet Med Gemellol (Roma). 1990;39(1):91-8.
Carmelli, D., Swan, G. E., Robinette, D., & Fabsitz, R. R. (1990). Heritability of substance use in the NAS-NRC Twin Registry. Acta Geneticae Medicae Et Gemellologiae, 39(1), pp. 91-8.
Carmelli D, et al. Heritability of Substance Use in the NAS-NRC Twin Registry. Acta Genet Med Gemellol (Roma). 1990;39(1):91-8. PubMed PMID: 2392895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heritability of substance use in the NAS-NRC Twin Registry. AU - Carmelli,D, AU - Swan,G E, AU - Robinette,D, AU - Fabsitz,R R, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 91 EP - 8 JF - Acta geneticae medicae et gemellologiae JO - Acta Genet Med Gemellol (Roma) VL - 39 IS - 1 N2 - This study examines the heritability of cigarette smoking, alcohol, and coffee consumption in 4,960 adult, male twin pairs (2,390 MZ and 2,570 DZ pairs) participants in an epidemiologic survey of the NAS-NRC Twin Registry conducted in the USA during 1972-73. Heritability estimates for smoking, alcohol and coffee use were calculated both before and after adjustment for shared variance between these behaviors and other demographic characteristics including socioeconomic status and an occupational adjustment score. The objective of the analysis was to determine the impact of adjustment for covariates on heritability estimates of smoking, alcohol and coffee use. Before adjustment, genetic effects in smoking, alcohol and coffee use accounted for 53%, 36%, and 45% of the variance, respectively. After adjustment, the corresponding estimates were 35%, 29%, and 36%. The fact that these estimates remained significant after adjustment for covariates leads to increased confidence about the role of genetic factors in substance use behaviors. SN - 0001-5660 UR - https://www.unboundmedicine.com/medline/citation/2392895/Heritability_of_substance_use_in_the_NAS_NRC_Twin_Registry_ L2 - https://ClinicalTrials.gov/search/term=2392895 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -