Tags

Type your tag names separated by a space and hit enter

Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa.
Int J Cancer. 2014 Mar 15; 134(6):1389-98.IJ

Abstract

In sub-Saharan Africa, invasive cervical cancer (ICC) incidence and mortality are among the highest in the world. This cross-sectional epidemiological study assessed human papillomavirus (HPV) prevalence and type distribution in women with ICC in Ghana, Nigeria, and South Africa. Cervical biopsy specimens were obtained from women aged ≥ 21 years with lesions clinically suggestive of ICC. Histopathological diagnosis of ICC was determined by light microscopy examination of hematoxylin and eosin stained sections of paraffin-embedded cervical specimens; samples with a confirmed histopathological diagnosis underwent HPV DNA testing by polymerase chain reaction. HPV-positive specimens were typed by reverse hybridization line probe assay. Between October 2007 and March 2010, cervical specimens from 659 women were collected (167 in Ghana, 192 in Nigeria and 300 in South Africa); 570 cases were histologically confirmed as ICC. The tumor type was identified in 551/570 women with ICC; squamous cell carcinoma was observed in 476/570 (83.5%) cases. The HPV-positivity rate in ICC cases was 90.4% (515/570). In ICC cases with single HPV infection (447/515 [86.8%]), the most commonly detected HPV types were HPV16 (51.2%), HPV18 (17.2%), HPV35 (8.7%), HPV45 (7.4%), HPV33 (4.0%) and HPV52 (2.2%). The prevalence of single and multiple HPV infections seemed higher among HIV-positive women and HPV type distribution appeared to differ according to tumor type and HIV status. In conclusion, HPV16, 18, 45 and 35 were the most common HPV types in sub-Saharan African women with ICC and HPV infections were more common in HIV-positive women.

Authors+Show Affiliations

Department of Obstetrics & Gynecology, University of Cape Town/Groote Schuur Hospital, Cape Town, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23929250

Citation

Denny, Lynette, et al. "Human Papillomavirus Prevalence and Type Distribution in Invasive Cervical Cancer in sub-Saharan Africa." International Journal of Cancer, vol. 134, no. 6, 2014, pp. 1389-98.
Denny L, Adewole I, Anorlu R, et al. Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa. Int J Cancer. 2014;134(6):1389-98.
Denny, L., Adewole, I., Anorlu, R., Dreyer, G., Moodley, M., Smith, T., Snyman, L., Wiredu, E., Molijn, A., Quint, W., Ramakrishnan, G., & Schmidt, J. (2014). Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa. International Journal of Cancer, 134(6), 1389-98. https://doi.org/10.1002/ijc.28425
Denny L, et al. Human Papillomavirus Prevalence and Type Distribution in Invasive Cervical Cancer in sub-Saharan Africa. Int J Cancer. 2014 Mar 15;134(6):1389-98. PubMed PMID: 23929250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa. AU - Denny,Lynette, AU - Adewole,Isaac, AU - Anorlu,Rose, AU - Dreyer,Greta, AU - Moodley,Manivasan, AU - Smith,Trudy, AU - Snyman,Leon, AU - Wiredu,Edwin, AU - Molijn,Anco, AU - Quint,Wim, AU - Ramakrishnan,Gunasekaran, AU - Schmidt,Johannes, Y1 - 2013/11/14/ PY - 2013/02/04/received PY - 2013/07/15/accepted PY - 2013/8/10/entrez PY - 2013/8/10/pubmed PY - 2014/2/26/medline KW - human papillomavirus KW - invasive cervical cancer KW - sub-Saharan Africa SP - 1389 EP - 98 JF - International journal of cancer JO - Int J Cancer VL - 134 IS - 6 N2 - In sub-Saharan Africa, invasive cervical cancer (ICC) incidence and mortality are among the highest in the world. This cross-sectional epidemiological study assessed human papillomavirus (HPV) prevalence and type distribution in women with ICC in Ghana, Nigeria, and South Africa. Cervical biopsy specimens were obtained from women aged ≥ 21 years with lesions clinically suggestive of ICC. Histopathological diagnosis of ICC was determined by light microscopy examination of hematoxylin and eosin stained sections of paraffin-embedded cervical specimens; samples with a confirmed histopathological diagnosis underwent HPV DNA testing by polymerase chain reaction. HPV-positive specimens were typed by reverse hybridization line probe assay. Between October 2007 and March 2010, cervical specimens from 659 women were collected (167 in Ghana, 192 in Nigeria and 300 in South Africa); 570 cases were histologically confirmed as ICC. The tumor type was identified in 551/570 women with ICC; squamous cell carcinoma was observed in 476/570 (83.5%) cases. The HPV-positivity rate in ICC cases was 90.4% (515/570). In ICC cases with single HPV infection (447/515 [86.8%]), the most commonly detected HPV types were HPV16 (51.2%), HPV18 (17.2%), HPV35 (8.7%), HPV45 (7.4%), HPV33 (4.0%) and HPV52 (2.2%). The prevalence of single and multiple HPV infections seemed higher among HIV-positive women and HPV type distribution appeared to differ according to tumor type and HIV status. In conclusion, HPV16, 18, 45 and 35 were the most common HPV types in sub-Saharan African women with ICC and HPV infections were more common in HIV-positive women. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23929250/Human_papillomavirus_prevalence_and_type_distribution_in_invasive_cervical_cancer_in_sub_Saharan_Africa_ L2 - https://doi.org/10.1002/ijc.28425 DB - PRIME DP - Unbound Medicine ER -