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Bioactive stilbenes from Vitis vinifera grapevine shoots extracts.
J Sci Food Agric. 2014 Mar 30; 94(5):951-4.JS

Abstract

BACKGROUND

Viticultural residues from commercial viticultural activities represent a potentially important source of bioactive stilbenes such as resveratrol. The main aim of the present study was therefore to isolate, identify and perform biological assays against amyloid-β peptide aggregation of original stilbenes from Vitis vinifera shoots.

RESULTS

A new resveratrol oligomer, (Z)-cis-miyabenol C (3), was isolated from Vitis vinifera grapevine shoots together with two newly reported oligostilbenes from Vitis vinifera shoots, vitisinol C (1) and (E)-cis-miyabenol C (2), and six known compounds: piceatannol, resveratrol, (E)-ε-viniferin (trans-ε-viniferin), ω-viniferin, vitisinol C and (E)-miyabenol C. The structures of these resveratrol derivatives were established on the basis of detailed spectroscopic analysis including nuclear magnetic resonance experiments. All the newly reported compounds were tested for their anti-aggregative activity against amyloid-β fibril formation. Vitisinol C was found to exert a significant activity against amyloid-β aggregation.

CONCLUSION

Vitis vinifera grapevine shoots are potentially interesting as a source of new bioactive stilbenes, such as vitisinol C.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Chaher N
Université de Bejaia, Faculté des Sciences de la Nature et de la vie, Laboratoire de Biochimie Appliquée, Bejaia, 06000, Algérie.
Arraki K
No affiliation info available
Dillinseger E
No affiliation info available
Temsamani H
No affiliation info available
Bernillon S
No affiliation info available
Pedrot E
No affiliation info available
Delaunay JC
No affiliation info available
Mérillon JM
No affiliation info available
Monti JP
No affiliation info available
Izard JC
No affiliation info available
Atmani D
No affiliation info available
Richard T
No affiliation info available

MeSH

AgricultureAmyloid beta-PeptidesBenzofuransChromatography, High Pressure LiquidDrug DiscoveryFranceHumansIndustrial WasteMolecular StructureNeuroprotective AgentsNootropic AgentsPeptide FragmentsPhenolsPlant ExtractsPlant ShootsProtein AggregatesProtein Aggregation, PathologicalSpectrometry, Mass, Electrospray IonizationStereoisomerismStilbenesVitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23929536

Citation

Chaher, Nassima, et al. "Bioactive Stilbenes From Vitis Vinifera Grapevine Shoots Extracts." Journal of the Science of Food and Agriculture, vol. 94, no. 5, 2014, pp. 951-4.
Chaher N, Arraki K, Dillinseger E, et al. Bioactive stilbenes from Vitis vinifera grapevine shoots extracts. J Sci Food Agric. 2014;94(5):951-4.
Chaher, N., Arraki, K., Dillinseger, E., Temsamani, H., Bernillon, S., Pedrot, E., Delaunay, J. C., Mérillon, J. M., Monti, J. P., Izard, J. C., Atmani, D., & Richard, T. (2014). Bioactive stilbenes from Vitis vinifera grapevine shoots extracts. Journal of the Science of Food and Agriculture, 94(5), 951-4. https://doi.org/10.1002/jsfa.6341
Chaher N, et al. Bioactive Stilbenes From Vitis Vinifera Grapevine Shoots Extracts. J Sci Food Agric. 2014 Mar 30;94(5):951-4. PubMed PMID: 23929536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive stilbenes from Vitis vinifera grapevine shoots extracts. AU - Chaher,Nassima, AU - Arraki,Kamel, AU - Dillinseger,Elsa, AU - Temsamani,Hamza, AU - Bernillon,Stéphane, AU - Pedrot,Eric, AU - Delaunay,Jean-Claude, AU - Mérillon,Jean-Michel, AU - Monti,Jean-Pierre, AU - Izard,Jean-Claude, AU - Atmani,Djebbar, AU - Richard,Tristan, Y1 - 2013/09/04/ PY - 2013/05/07/received PY - 2013/07/30/revised PY - 2013/08/08/accepted PY - 2013/8/10/entrez PY - 2013/8/10/pubmed PY - 2014/12/17/medline KW - LC-MS KW - NMR KW - Vitis vinifera KW - amyloid-β KW - stilbene SP - 951 EP - 4 JF - Journal of the science of food and agriculture JO - J Sci Food Agric VL - 94 IS - 5 N2 - BACKGROUND: Viticultural residues from commercial viticultural activities represent a potentially important source of bioactive stilbenes such as resveratrol. The main aim of the present study was therefore to isolate, identify and perform biological assays against amyloid-β peptide aggregation of original stilbenes from Vitis vinifera shoots. RESULTS: A new resveratrol oligomer, (Z)-cis-miyabenol C (3), was isolated from Vitis vinifera grapevine shoots together with two newly reported oligostilbenes from Vitis vinifera shoots, vitisinol C (1) and (E)-cis-miyabenol C (2), and six known compounds: piceatannol, resveratrol, (E)-ε-viniferin (trans-ε-viniferin), ω-viniferin, vitisinol C and (E)-miyabenol C. The structures of these resveratrol derivatives were established on the basis of detailed spectroscopic analysis including nuclear magnetic resonance experiments. All the newly reported compounds were tested for their anti-aggregative activity against amyloid-β fibril formation. Vitisinol C was found to exert a significant activity against amyloid-β aggregation. CONCLUSION: Vitis vinifera grapevine shoots are potentially interesting as a source of new bioactive stilbenes, such as vitisinol C. SN - 1097-0010 UR - https://www.unboundmedicine.com/medline/citation/23929536/Bioactive_stilbenes_from_Vitis_vinifera_grapevine_shoots_extracts_ DB - PRIME DP - Unbound Medicine ER -