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Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat.
Behav Brain Res 2013; 256:108-18BB

Abstract

In order to identify the differences for the onset and progression of functionally distinct cholinergic innervation disorders, we investigated the effect of bilateral nucleus basalis (NB) and pedunculopontine tegmental nucleus (PPT) lesions on sleep/wake states and electroencephalographic (EEG) microstructure in rats, chronically implanted for sleep recording. Bilateral NB lesion transiently altered Wake/NREM duration within the sensorimotor cortex, and Wake/REM duration within the motor cortex, while there was no change in the sleep/wake states distributions following the bilateral PPT lesion. Bilateral PPT lesion sustainably increased the Wake/REM and REM/Wake transitions followed by inconsistent dysregulation of the NREM/REM and REM/NREM transitions in sensorimotor cortex, but oppositely by their increment throughout four weeks in motor cortex. Bilateral NB lesion sustainably decreased the NREM/REM and REM/NREM transitions during four weeks in the sensorimotor cortex, but oppositely increased them in the motor cortex. We have shown that the sustained beta and gamma augmentation within the sensorimotor and motor cortex, and across all sleep/wake states, simultaneously with Wake delta amplitude attenuation only within the sensorimotor cortex, were the underlying EEG microstructure for the sleep/wake states transitions structure disturbance following bilateral PPT lesion. In contrast, the bilateral NB lesion only augmented REM theta in sensorimotor cortex during three weeks. We have shown that the NB and PPT lesions induced differing, structure-related EEG microstructure and transition structure disturbances particularly expressed in motor cortex during NREM and REM sleep. We evidenced for the first time the different topographical expression of the functionally distinct cholinergic neuronal innervation impairment in rat.

Authors+Show Affiliations

University of Belgrade, Department of Neurobiology, Institute for Biological Research - Sinisa Stankovic, 11 060 Belgrade, Serbia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23933142

Citation

Petrovic, Jelena, et al. "Topography of the Sleep/wake States Related EEG Microstructure and Transitions Structure Differentiates the Functionally Distinct Cholinergic Innervation Disorders in Rat." Behavioural Brain Research, vol. 256, 2013, pp. 108-18.
Petrovic J, Lazic K, Ciric J, et al. Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat. Behav Brain Res. 2013;256:108-18.
Petrovic, J., Lazic, K., Ciric, J., Kalauzi, A., & Saponjic, J. (2013). Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat. Behavioural Brain Research, 256, pp. 108-18. doi:10.1016/j.bbr.2013.07.047.
Petrovic J, et al. Topography of the Sleep/wake States Related EEG Microstructure and Transitions Structure Differentiates the Functionally Distinct Cholinergic Innervation Disorders in Rat. Behav Brain Res. 2013 Nov 1;256:108-18. PubMed PMID: 23933142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat. AU - Petrovic,Jelena, AU - Lazic,Katarina, AU - Ciric,Jelena, AU - Kalauzi,Aleksandar, AU - Saponjic,Jasna, Y1 - 2013/08/06/ PY - 2013/06/24/received PY - 2013/07/22/revised PY - 2013/07/26/accepted PY - 2013/8/13/entrez PY - 2013/8/13/pubmed PY - 2014/12/19/medline KW - Cholinergic neurons KW - Ibotenic acid KW - Lesion KW - Nucleus basalis KW - Pedunculopontine tegmental nucleus SP - 108 EP - 18 JF - Behavioural brain research JO - Behav. Brain Res. VL - 256 N2 - In order to identify the differences for the onset and progression of functionally distinct cholinergic innervation disorders, we investigated the effect of bilateral nucleus basalis (NB) and pedunculopontine tegmental nucleus (PPT) lesions on sleep/wake states and electroencephalographic (EEG) microstructure in rats, chronically implanted for sleep recording. Bilateral NB lesion transiently altered Wake/NREM duration within the sensorimotor cortex, and Wake/REM duration within the motor cortex, while there was no change in the sleep/wake states distributions following the bilateral PPT lesion. Bilateral PPT lesion sustainably increased the Wake/REM and REM/Wake transitions followed by inconsistent dysregulation of the NREM/REM and REM/NREM transitions in sensorimotor cortex, but oppositely by their increment throughout four weeks in motor cortex. Bilateral NB lesion sustainably decreased the NREM/REM and REM/NREM transitions during four weeks in the sensorimotor cortex, but oppositely increased them in the motor cortex. We have shown that the sustained beta and gamma augmentation within the sensorimotor and motor cortex, and across all sleep/wake states, simultaneously with Wake delta amplitude attenuation only within the sensorimotor cortex, were the underlying EEG microstructure for the sleep/wake states transitions structure disturbance following bilateral PPT lesion. In contrast, the bilateral NB lesion only augmented REM theta in sensorimotor cortex during three weeks. We have shown that the NB and PPT lesions induced differing, structure-related EEG microstructure and transition structure disturbances particularly expressed in motor cortex during NREM and REM sleep. We evidenced for the first time the different topographical expression of the functionally distinct cholinergic neuronal innervation impairment in rat. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/23933142/Topography_of_the_sleep/wake_states_related_EEG_microstructure_and_transitions_structure_differentiates_the_functionally_distinct_cholinergic_innervation_disorders_in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(13)00459-2 DB - PRIME DP - Unbound Medicine ER -