Tags

Type your tag names separated by a space and hit enter

Antidiabetic effect of total flavonoids from Sanguis draxonis in type 2 diabetic rats.
J Ethnopharmacol. 2013 Oct 07; 149(3):729-36.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Sanguis draxonis (SD) is a kind of red resin obtained from the wood of Dracaena cochinchinensis (Lour.) S. C. Chen (Dracaena cochinchinensis). It is a Chinese traditional herb that is prescribed for the handling of diabetic disorders, which is also supported by an array of scientific studies published in recent years. Although chemical constituents of this plant material have also been previously evaluated (Tang et al., 1995; Wei et al., 1998), it still remains poorly understood which constituent is the major contributor to its antidiabetic activities. Moreover, very little is known about the molecular mechanisms underlying antidiabetic activities of SD. Flavonoids exist at a high level in SD. The aim of this study is to evaluate the antidiabetic effects of total flavonoids from SD (SDF) in type 2 Diabetes mellitus (T2DM) rats.

MATERIALS AND METHODS

T2DM rats were induced by 4 weeks high-fat diet and a singular injection of streptozotocin (STZ) (35mg/kg). Then T2DM rats were treated with SDF for 21 days, using normal saline as the negative control. For comparison, a standard antidiabetic drug, metformin (200mg/kg), was used as a positive control. Three weeks later, relative biochemical indexes were determined and histopathological examinations were performed to assess the antidiabetic activities of SDF.

RESULTS

SDF not only exhibited a significant hypoglycemic activity, but also alleviated dyslipidemia, tissue steatosis, and oxidative stress associated with T2DM. Moreover, considerable pancreatic islet protecting effects could be observed after SDF treatment. Further investigations revealed a potential anti-inflammation activity of SDF by determining serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP).

CONCLUSIONS

This study demonstrates both hypoglycemic and hypolipidemic effects of SDF in T2DM rats, suggesting that flavonoids are the major active ingredients accounting for the antidiabetic activity of SD. Alleviating chronic inflammation responses and protecting pancreatic islets are possible mechanisms involved in the antidiabetic activity of SDF.

Authors+Show Affiliations

College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23933499

Citation

Chen, Fufeng, et al. "Antidiabetic Effect of Total Flavonoids From Sanguis Draxonis in Type 2 Diabetic Rats." Journal of Ethnopharmacology, vol. 149, no. 3, 2013, pp. 729-36.
Chen F, Xiong H, Wang J, et al. Antidiabetic effect of total flavonoids from Sanguis draxonis in type 2 diabetic rats. J Ethnopharmacol. 2013;149(3):729-36.
Chen, F., Xiong, H., Wang, J., Ding, X., Shu, G., & Mei, Z. (2013). Antidiabetic effect of total flavonoids from Sanguis draxonis in type 2 diabetic rats. Journal of Ethnopharmacology, 149(3), 729-36. https://doi.org/10.1016/j.jep.2013.07.035
Chen F, et al. Antidiabetic Effect of Total Flavonoids From Sanguis Draxonis in Type 2 Diabetic Rats. J Ethnopharmacol. 2013 Oct 7;149(3):729-36. PubMed PMID: 23933499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effect of total flavonoids from Sanguis draxonis in type 2 diabetic rats. AU - Chen,Fufeng, AU - Xiong,Hui, AU - Wang,Jianxia, AU - Ding,Xin, AU - Shu,Guangwen, AU - Mei,Zhinan, Y1 - 2013/08/07/ PY - 2013/01/09/received PY - 2013/07/08/revised PY - 2013/07/24/accepted PY - 2013/8/13/entrez PY - 2013/8/13/pubmed PY - 2014/4/22/medline KW - C-reactive protein KW - CRP KW - D. cochinchinensis KW - Dracaena cochinchinensis (Lour.) S. C. Chen KW - Dyslipidemia KW - ELISA KW - FFA KW - Flavonoids KW - GSH KW - HDL-C KW - HE KW - IL-6 KW - IR KW - ITT KW - Inflammation KW - LDL-C KW - MDA KW - OGTT KW - Oxidative stress KW - ROS KW - SD KW - SDF KW - SOD KW - STZ KW - T1DM KW - T2DM KW - TC KW - TG KW - TNF-α KW - Type 2 Diabetic mellitus KW - enzyme-linked immunosorbent assay KW - free fatty acids KW - glutathione KW - hematoxylin-eosin KW - high density lipoprotein cholesterol KW - insulin resistance KW - insulin tolerance test KW - interleukin-6 KW - low density lipoprotein cholesterol KW - malondialdehyde KW - oral glucose tolerance test KW - reactive oxygen species KW - sanguis draxonis KW - streptozotocin KW - superoxide dismutase KW - total cholesterol KW - total flavonoids from SD KW - triglycerides KW - tumor necrosis factor-alpha KW - type 1 Diabetes mellitus KW - type 2 Diabetes mellitus SP - 729 EP - 36 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 149 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Sanguis draxonis (SD) is a kind of red resin obtained from the wood of Dracaena cochinchinensis (Lour.) S. C. Chen (Dracaena cochinchinensis). It is a Chinese traditional herb that is prescribed for the handling of diabetic disorders, which is also supported by an array of scientific studies published in recent years. Although chemical constituents of this plant material have also been previously evaluated (Tang et al., 1995; Wei et al., 1998), it still remains poorly understood which constituent is the major contributor to its antidiabetic activities. Moreover, very little is known about the molecular mechanisms underlying antidiabetic activities of SD. Flavonoids exist at a high level in SD. The aim of this study is to evaluate the antidiabetic effects of total flavonoids from SD (SDF) in type 2 Diabetes mellitus (T2DM) rats. MATERIALS AND METHODS: T2DM rats were induced by 4 weeks high-fat diet and a singular injection of streptozotocin (STZ) (35mg/kg). Then T2DM rats were treated with SDF for 21 days, using normal saline as the negative control. For comparison, a standard antidiabetic drug, metformin (200mg/kg), was used as a positive control. Three weeks later, relative biochemical indexes were determined and histopathological examinations were performed to assess the antidiabetic activities of SDF. RESULTS: SDF not only exhibited a significant hypoglycemic activity, but also alleviated dyslipidemia, tissue steatosis, and oxidative stress associated with T2DM. Moreover, considerable pancreatic islet protecting effects could be observed after SDF treatment. Further investigations revealed a potential anti-inflammation activity of SDF by determining serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP). CONCLUSIONS: This study demonstrates both hypoglycemic and hypolipidemic effects of SDF in T2DM rats, suggesting that flavonoids are the major active ingredients accounting for the antidiabetic activity of SD. Alleviating chronic inflammation responses and protecting pancreatic islets are possible mechanisms involved in the antidiabetic activity of SDF. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/23933499/Antidiabetic_effect_of_total_flavonoids_from_Sanguis_draxonis_in_type_2_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -